Lemairamin (WGX-50) mea hana pauka CAS No.: 29946-61-0 98.0% maemae min.no nā mea hoʻohui
Nā Kūlana Huahana
| Inoa mea kūʻai | Lemairamina |
| inoa ʻē aʻe | 2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-; Lemairamina (WGX-50) |
| CAS No. | 29946-61-0 |
| ʻAno molekala | C19H21NO3 |
| Kaumaha molekula | 311.37 |
| Maemae | 98.0% |
| Ka nana aku | ʻO ka pauka keʻokeʻo keʻokeʻo |
| Palapala noi | Mea ʻai meaʻai kumu |
Hoʻolauna huahana
ʻO ka Lemairamin a i ʻole Wgx50 kahi hui kūlohelohe i unuhi ʻia mai nā pepa chili i hōʻike i nā hopena maikaʻi i ka pale ʻana i ka maʻi o Alzheimer.Ua ʻike nā haʻawina hiki iā ia ke kāohi i ka apoptosis neuronal Aβ-induced, hoʻemi i ka ʻona calcium neuronal, a hoʻemi i ka hōʻiliʻili ʻana o nā oligomers Aβ i ka cerebral cortex.Eia hou, ua hōʻike ʻia ka wgx50 e hoʻomaikaʻi i ka hana cognitive i nā ʻiole.Hōʻike ka noiʻi he hiki i ka wgx50 ke pale i ka hui pūmua-protein ma waena o nā moleke amyloid.ʻO ka holoʻokoʻa, hiki i ka wgx50 ke pale i ka maʻi o Alzheimer a hiki ke hāʻawi i nā ala hou no ka hoʻomohala ʻana i nā lāʻau lapaʻau e kuhikuhi ana i nā oligomers Aβ.Hoʻohui ʻia, hōʻike ʻo WGX-50 i ka hana anti-inflammatory koʻikoʻi, e lilo ia i moho hoʻohiki no ka mālama ʻana i nā maʻi ʻeha.Ua ʻike ʻia ʻo WGX-50 i nā hopena koʻikoʻi ma ka ʻili, e like me ka hōʻemi ʻana i nā wrinkles a me ka hoʻomaikaʻi ʻana i ka elasticity ʻili.Ma waho aʻe o nā pūhui kūlohelohe i lawe ʻia mai ka mea kanu Zanthoxylum bungeanum, aia i kēia manawa nā mea hoʻohuihui synthetic i hoʻohana ʻia i nā noi like ʻole a ʻoi aku ka maikaʻi no ka mākeke.
Hiʻona
(1) Maʻemaʻe kiʻekiʻe: Hiki i ka Lemairamin ke loaʻa i nā huahana maʻemaʻe kiʻekiʻe ma o ka ʻili kūlohelohe a me ka hoʻomaʻemaʻe ʻana i nā kaʻina hana.ʻO ka maʻemaʻe kiʻekiʻe, ʻoi aku ka maikaʻi o ka bioavailability a me ka liʻiliʻi o nā hopena ʻino.
(2) Palekana: Palekana kiʻekiʻe, liʻiliʻi nā hopena maikaʻi ʻole, ʻaʻohe hopena maikaʻi ʻole me ka hoʻohana lōʻihi.
(3) Paʻa: He kūpaʻa maikaʻi ka Lemairamin a hiki ke mālama i kāna hana a me ka hopena ma lalo o nā kaiapuni like ʻole a me nā kūlana mālama.
(4) Maʻalahi ke komo: Hiki ke hoʻopili koke ʻia ka Lemairamin e ke kino kanaka a hāʻawi ʻia i nā ʻiʻo a me nā ʻāpana like ʻole.
Nā noi
ʻO Lemairamin kahi pūhui amide i lawe ʻia mai ka ʻili o ka mea kanu Zanthoxylum bungeanum.Hoʻohana ʻia i kēia manawa ma ke ʻano he meaʻai meaʻai, hana pū ia ma ke ʻano he agonist o ka alpha7 nicotinic acetylcholine receptor (α7nAChR), ka mea e hōʻemi ai i ka neuroinflammation i ka maʻi o Alzheimer, a ua synthetic loa. apoptosis, ho'ēmi i ka neuronal calcium toxicity, hoʻemi i ka hōʻiliʻili o Aβ oligomers i loko o ka cerebral cortex, a me ka hoʻomaikaʻi ʻana i ka hana cognitive i nā ʻiole.
