Mea hana pauka Lemairamin (WGX-50) CAS No.: 29946-61-0 98.0% maʻemaʻe min. no nā mea hoʻohui
Wikiō Huahana
Nā Palena Huahana
| Inoa huahana | ʻO Lemairamina |
| Inoa ʻē aʻe | 2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-; ʻO Lemairamin (WGX-50) |
| Helu CAS. | 29946-61-0 |
| ʻO ke ʻano molekole | C19H21NO3 |
| Kaumaha molekole | 311.37 |
| Maʻemaʻe | 98.0% |
| helehelena | Pauka keʻokeʻo a keʻokeʻo paha |
| Noi | Mea Hoʻohui Meaʻai Maka |
Hoʻolauna huahana
ʻO Lemairamin a i ʻole Wgx50 kahi hui kūlohelohe i unuhi ʻia mai nā pepa chili i hōʻike i nā hopena hoʻohiki i ka pale ʻana i ka maʻi Alzheimer. Ua ʻike ʻia nā haʻawina hiki iā ia ke kāohi i ka apoptosis neuronal i hoʻokomo ʻia e Aβ, hoʻēmi i ka ʻona calcium neuronal, a hoʻēmi i ka hōʻiliʻili ʻana o nā oligomers Aβ i loko o ka cortex cerebral. Eia kekahi, ua hōʻike ʻia ʻo wgx50 e hoʻomaikaʻi i ka hana cognitive i nā ʻiole. Hōʻike ka noiʻi he hiki iā wgx50 ke pale i ka hui ʻana o ka protein-protein ma waena o nā molekala amyloid. Ma keʻano holoʻokoʻa, loaʻa iā wgx50 ka hiki ke pale i ka maʻi Alzheimer a hiki ke hāʻawi i nā ala hou no ka hoʻomohala ʻana i nā lāʻau lapaʻau e kuhikuhi ana i nā oligomers Aβ. Eia kekahi, hōʻike ʻo WGX-50 i ka hana anti-inflammatory koʻikoʻi, ka mea e lilo ai ia i moho hoʻohiki no ka mālama ʻana i nā maʻi mumū. Ua ʻike ʻia he hopena koʻikoʻi ko WGX-50 i ka ʻili, e like me ka hoʻēmi ʻana i nā wrinkles a me ka hoʻomaikaʻi ʻana i ka elasticity o ka ʻili. Ma waho aʻe o nā hui kūlohelohe i unuhi ʻia mai ka mea kanu ʻo Zanthoxylum bungeanum, aia i kēia manawa nā hui synthetic i hoʻohana ʻia i nā noi like ʻole a ʻoi aku ka kūpono no ka mākeke.
Hiʻona
(1) Maʻemaʻe kiʻekiʻe: Hiki iā Lemairamin ke loaʻa nā huahana maʻemaʻe kiʻekiʻe ma o ka unuhi kūlohelohe a me nā kaʻina hana hoʻomaʻemaʻe. ʻO ke ʻano o ka maʻemaʻe kiʻekiʻe ʻo ia hoʻi ka bioavailability maikaʻi a me nā hopena ʻino liʻiliʻi.
(2) Palekana: Palekana kiʻekiʻe, kakaikahi nā hopena maikaʻi ʻole, ʻaʻohe hopena maikaʻi ʻole maopopo me ka hoʻohana lōʻihi.
(3) Paʻa: Loaʻa iā Lemairamin ke kūpaʻa maikaʻi a hiki ke mālama i kāna hana a me ka hopena ma lalo o nā ʻano like ʻole a me nā kūlana mālama.
(4) Maʻalahi ke omo: Hiki ke omo koke ʻia ʻo Lemairamin e ke kino o ke kanaka a hoʻolaha ʻia i nā ʻiʻo a me nā ʻōpū like ʻole.
Nā noi
ʻO Lemairamin kahi hui amide i unuhi ʻia mai ka ʻili o ka mea kanu Zanthoxylum bungeanum. Hoʻohana ʻia i kēia manawa ma ke ʻano he mea hoʻohui meaʻai, hana pū ia ma ke ʻano he agonist o ka alpha7 nicotinic acetylcholine receptor (α7nAChR), ka mea e hōʻemi ana i ka neuroinflammation i ka maʻi Alzheimer, a ua synthetic loa. Ua hōʻike ʻo Wgx50 i nā hopena hoʻoikaika i nā haʻawina preclinical, me ka pale ʻana i ka apoptosis neuronal i hoʻokomo ʻia e Aβ, ka hōʻemi ʻana i ka ʻona calcium neuronal, ka hōʻemi ʻana i ka hōʻiliʻili ʻana o nā oligomers Aβ i loko o ka cerebral cortex, a me ka hoʻomaikaʻi ʻana i ka hana cognitive i nā ʻiole.












