O-304 CAS No.:1261289-04-6 Kūkulu i nā ʻiʻo a hoʻemi i ka momona.
Nā Palena Huahana
| Inoa huahana | ʻO-304 |
| Inoa ʻē aʻe | 4-Kloro-N-[2-[(4-klorofenil)metil]-2,3-dihidro-3-okso-1,2,4-thiadiazol-5-yl]benzamide |
| Helu CAS. | 1261289-04-6 |
| ʻO ke ʻano molekole | C16H11Cl2N3O2S |
| Kaumaha molekole | 380.25 |
| Maʻemaʻe | 98% |
| helehelena | Pauka keʻokeʻo a keʻokeʻo paha |
| Hoʻopili ʻana | 1kg/ʻeke, 25kg/barela |
| Noi | Mea Hoʻohui Meaʻai Maka |
Hoʻolauna huahana
He mea hoʻoulu AMPK molekole liʻiliʻi ʻo O-304 e hoʻonui i ka hana AMPK ma ke kāohi ʻana i ka dephosphorylation o ka phosphorylated AMPK (pAMPK), no laila e hoʻonui ai i nā pae pAMPK me ka ʻole o ka hōʻemi ʻana i nā ʻāpana adenosine triphosphate intracellular (ATP). Loaʻa iā ia nā ʻano hana he nui, me ka hoʻomaikaʻi ʻana i ka metabolism glucose, ka hōʻemi ʻana i ke kūʻē ʻana o ka insulin, a me ka pale ʻana i ka ʻōnaehana cardiovascular.
Hiʻona
(1) Maʻemaʻe kiʻekiʻe: Hana ʻia ʻo O-304 ma o kahi kaʻina hana i hoʻomaʻemaʻe ʻia, e hoʻokō ana i ka maʻemaʻe huahana kiʻekiʻe. ʻO ke ʻano o ka maʻemaʻe kiʻekiʻe ʻo ia hoʻi ka bioavailability maikaʻi aʻe.
(2) Hana Olaola:He mea hoʻoikaika waha ʻo O-304 o AMPK (AMP-activated protein kinase). Hoʻonui ia i ka hana AMPK ma ke kāohi ʻana i ka dephosphorylation o pAMPK.
Nā noi
1. Hoʻāla ʻia ʻo AMPK: Hoʻonui ʻo O-304 i ka hana AMPK ma ke kāohi ʻana i ke kaʻina hana dephosphorylation o ka phosphorylated AMPK (pAMPK), no laila e hoʻoponopono ai i ke kaulike metabolism ikehu.
2. Hoʻomaikaʻi i ka metabolism glucose: I nā haʻawina holoholona, ua kōkua maikaʻi ka mahele o 100 mg/kg o O-304 i ka mālama ʻana i ka glucose koko hoʻokē ʻai a me nā pae insulin plasma paʻa, e hōʻemi nui ana i ke kaumaha metabolic i hoʻokumu ʻia e ka ʻai momona kiʻekiʻe, a me ka pale ʻana i nā loli o ka glucose koko a me ka piʻi ʻana o ka insulin maʻamau i hoʻoulu ʻia e nā hemahema ʻai.
3. Pka pale ʻana i ka elasticity vascular:Kōkua ʻo O-304 i ka mālama ʻana i ke koko ma nā pae olakino, hoʻemi i ke kaumaha ma luna o nā kīʻaha koko, a hāʻawi i ka palekana lōʻihi a mālie no nā ʻōnaehana cardiovascular a me cerebrovascular, e kākoʻo ana i ka paʻa o ka naʻau a me ka ikehu mau.
4.Ke paipai nei i ka ʻōpio mau loa:Hoʻopili pololei ʻo O-304 i ke ala hōʻailona AMPK-mTOR, e hoʻoponopono akamai ana i ke kaʻina hana o ka autophagy cellular, e paipai ana i ka catabolism o nā protein kahiko a me nā lipids maʻamau ʻole, a mālama i kahi ʻano cellular maʻemaʻe a olaola, a laila e hoʻopaneʻe ana i ka ʻelemakule ʻana o nā cellular.
