BAM15A CAS No.:210302-02-6 Kūkulu i nā ʻiʻo a hoʻemi i ka momona.
Nā Palena Huahana
| Inoa huahana | BAM15A |
| Inoa ʻē aʻe | N5,N6-Bis(2-Chlorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine |
| Helu CAS. | 210302-02-6 |
| ʻO ke ʻano molekole | C16H10Cl2N6O |
| Kaumaha molekole | 373.2 |
| Maʻemaʻe | 98% |
| helehelena | Pauka keʻokeʻo ʻeleʻele a melemele māmā |
| Hoʻopili ʻana | 1kg/ʻeke, 25kg/barela |
| Noi | Mea Hoʻohui Meaʻai Maka |
Hoʻolauna huahana
He modulator mitochondrial hanauna hou ʻo BAM15A. Ma ke ʻano he mea hoʻokaʻawale proton mitochondrial maikaʻi loa, hoʻoponopono mālie ia i ka gradient proton ma waena o ka membrane mitochondrial o loko, hoʻonui i ka pono o ka metabolism ikehu o ke kino a hoʻolalelale i ka haki ʻana o ka momona oxidative kūlohelohe, me ka ʻole o ka hoʻopilikia ʻana i ka nui o nā ʻiʻo a i ʻole ka makemake maʻamau.
Ua hōʻoia nā haʻawina preclinical e kōkua kēia mea hoʻohui i ka hoʻomaikaʻi ʻana i ka pehu ʻana o ke kino, hoʻonui i ka ʻike insulin, hōʻemi i ka hōʻiliʻili ʻana o ka momona ate a hōʻoluʻolu i nā pane mumū systemic. Loaʻa iā ia kahi bioavailability waha a hiki i ka 67% a haʻaheo i nā waiwai akahai me ka palekana kiʻekiʻe. ʻAʻole e like me nā mea like kuʻuna, ʻaʻole ia e hoʻoulu i ka mahana kino maʻamau a i ʻole ka hōʻino ʻana o nā cellular, e lilo ia i mea maka meaʻai maikaʻi loa no ka hoʻokele kaumaha a me ka hoʻoponopono metabolic.
Hiʻona
(1) Maʻemaʻe kiʻekiʻe: BAM15Ahiki ke hana i nā huahana maʻemaʻe kiʻekiʻe ma o ke kaʻina hana i hoʻomaʻemaʻe ʻia. ʻO ke ʻano o ka maʻemaʻe kiʻekiʻe ʻo ia hoʻi ka bioavailability ʻoi aku ka maikaʻi.
(2) ʻAno hana wehe pono: Ma ke ʻano he mea lawe proton mitochondrial, hoʻopilikia ia i ka gradient proton o ka membrane mitochondrial o loko, e paipai ana i ka hoʻololi ʻana o ka ikehu oxidative mai nā meaʻai i ka ikehu wela ma mua o ATP, e hoʻonui nui ana i ka hoʻohana ʻana i ka ikehu.
(3) Ka pohō momona palekana a me ka hoʻomaikaʻi ʻana i ka metabolic: I nā hoʻokolohua holoholona, ua hōʻea ka bioavailability waha i ka 67%, e hōʻemi ana i ka momona o ke kino ma mua o 20% me ka ʻole o ka hōʻemi ʻana i ka nui o nā ʻiʻo, e hoʻopilikia ana i ka makemake a i ʻole ka mahana o ke kino, me ka hoʻomaikaʻi ʻana i ka ʻike insulin, e hōʻoluʻolu ana i ke akepaʻa momona a me ka mumū.
(4) Pōmaikaʻi haʻahaʻa haʻahaʻa: Ke hoʻohālikelike ʻia me nā mea hoʻokaʻawale kuʻuna, ʻaʻohe pilikia o ke kuni kiʻekiʻe a i ʻole ka cytotoxicity. me ka ʻole o ka hōʻino ʻana o ke kino a i ʻole nā hopena ʻaoʻao neurological.
Nā noi
1. Ka hōʻemi ʻana i ka momona a me ka hoʻomaikaʻi ʻana i ka metabolism: Ma o ka mitochondrial uncoupling, hoʻemi nui ia i ka momona o ke kino (i nā hiʻohiʻona holoholona, e emi ana ka momona o ke kino ma mua o 20%), i ka manawa like e hoʻohaʻahaʻa i ke kō koko, ke kū'ē ʻana o ka insulin, a me ka hōʻiliʻili ʻana o ka momona o ke akepaʻa, me ka ʻole o ka hoʻopilikia ʻana i ka makemake a i ʻole ka nui o nā ʻiʻo;
2. Kū'ē i ka ʻelemakule: Hoʻonui i ka nui o nā ʻiʻo (ma ka 8%) a me ka ikaika (ma ka 40%) i nā holoholona ʻelemakule, hoʻemi i ka momona a kāohi i ka mumū mau loa, a hakakā i ka momona myogenic.
3. Anti-inflammatory: Hoʻemi i ka pilikia o ka hōʻeha puʻupaʻa koʻikoʻi (AKI) i hoʻokumu ʻia e ka sepsis, a hōʻoluʻolu i nā pane mumū ʻōnaehana ma ka pale ʻana i ka hana ROS mitochondrial a me ka hoʻokuʻu ʻana o mtDNA.
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