1-Methylnicotinamide Chloride CAS No.:1005-24-9
Nā Palena Huahana
| Inoa huahana | 1-Methylnicotinamide chloride |
| Inoa ʻē aʻe | N-Methylnicotinamide chloride；NMN-Cl；1-MNA chloride；3-carbamoyl-1-methyl-pyridinium chloride |
| Helu CAS. | 1005-24-9 |
| ʻO ke ʻano molekole | C7H9N2ʻOCl |
| Kaumaha molekole | 172.61 |
| Maʻemaʻe | 98.5% |
| helehelena | Keʻokeʻo - keʻokeʻo ʻālohilohi, paʻa anianipauka |
| Hoʻopili ʻana | 1kg/ʻeke; 25kg/pahu |
| Noi | chemikalaehoʻokolohuamnā mea hana |
Hoʻolauna huahana
ʻO 1-Methylnicotinamide chloride kahi methylated derivative o ka nicotinamide, i hōʻailona ʻia e kahi ʻano paʻakai ammonium quaternary paʻa. Hana ia ma ke ʻano he waena koʻikoʻi i ke aʻo ʻana i ka metabolism nicotinamide. ʻO kona solubility wai maikaʻi a me ke kūpaʻa kemika e hāʻawi iā ia i kūpono ma ke ʻano he hui mea hana no ka noiʻi biochemical.
He mea kūlohelohe ka 1-MNA i loko o ke kino o ke kanaka, e hana ana ma ke ʻano he huahana maʻamau o ka metabolism niacin. Ma ke ʻano he waena i kēia ala metabolic, ua hana hou ʻia ka 1-MNA e ka aldehyde oxidase e hana i nā metabolites ma lalo e like me N-methyl-2-pyridone-5-carboxamide (2PY) a me N-methyl-4-pyridone-3-carboxamide (4PY), kahi i hoʻokuʻu ʻia ma o ka ʻōnaehana urinary.
ʻO 1-Methylnicotinamide chloride kahi methylated derivative o ka nicotinamide, i hōʻailona ʻia e kahi ʻano paʻakai ammonium quaternary paʻa. Hana ia ma ke ʻano he waena koʻikoʻi i ke aʻo ʻana i ka metabolism nicotinamide. ʻO kona solubility wai maikaʻi a me ke kūpaʻa kemika e hāʻawi iā ia i kūpono ma ke ʻano he hui mea hana no ka noiʻi biochemical.
He mea kūlohelohe ka 1-MNA i loko o ke kino o ke kanaka, e hana ana ma ke ʻano he huahana maʻamau o ka metabolism niacin. Ma ke ʻano he waena i kēia ala metabolic, ua hana hou ʻia ka 1-MNA e ka aldehyde oxidase e hana i nā metabolites ma lalo e like me N-methyl-2-pyridone-5-carboxamide (2PY) a me N-methyl-4-pyridone-3-carboxamide (4PY), kahi i hoʻokuʻu ʻia ma o ka ʻōnaehana urinary.
Hiʻona
(1) Ka hoʻoheheʻe ʻana i ka wai: Hoʻoheheʻe koke ʻia i loko o ka wai a me nā mea hoʻoheheʻe organik polar.
(2) Paʻa: Paʻa ma lalo o nā kūlana mahana o ka lumi akā pono e mālama ʻia i loko o nā wahi pale i ka makū.
(3) Palekana: Ua hana ka ʻAhahui ʻEulopa i kahi loiloi ʻepekema o 1-MNA ma ke ʻano he meaʻai hou. Wahi a ka EU Regulation (EC) No 258/97, ua manaʻo ʻia ʻo 1-MNA he palekana no ka ʻai ʻana, me ka nui o ka lawe ʻana o ka pākeke i kēlā me kēia lā he 58 mg, i manaʻo nui ʻia no ka hoʻohana ʻana i nā mea hoʻohui meaʻai.
Nā noi
ʻO 1-Methylnicotinamide chloride (i hoʻopōkole ʻia e like me MNC) kahi methylated derivative o nicotinamide. Hiki ke hoʻokō ʻia ka ʻike ʻana o 1-MNA ma o nā ʻano hana e like me ka high-performance liquid chromatography (HPLC) a me ka enzyme-linked immunosorbent assay (ELISA). Hōʻike ia i ka hiki ke hoʻohana ʻia i loko o nā ʻāpana meaʻai a me nā huahana olakino. I loko o ka ʻoihana meaʻai, hiki iā ia ke hana ma ke ʻano he antioxidant e hoʻopaneʻe i ka lipid oxidation a mālama i ka maikaʻi o ka meaʻai. Ma muli o kona mau ʻano hoʻonohonoho, hiki iā ia ke lawelawe ma ke ʻano he mea hana i nā meaʻai i hoʻoikaika ʻia i ka meaʻai. Eia kekahi, hōʻike ʻo 1-MNA i nā hana i ka hoʻoponopono metabolic a me ka hoʻomaikaʻi ʻana i nā kūlana physiological, e hāʻawi ana i ka waiwai no ka hoʻomohala ʻana i nā meaʻai hana a me nā mea hoʻohui meaʻai e lawe ana i nā koi olakino.
Ua hoʻoholo ka loiloi EU ʻaʻole paha e alakaʻi ka lawe ʻana i 58 mg o 1-MNA i kēlā me kēia lā mai nā mea hoʻopihapiha meaʻai i nā hopena maikaʻi ʻole i ke olakino kanaka, a ua hoʻokomo kūhelu ʻia ia i loko o ka papa inoa meaʻai hou o EU.
Ma ke ʻano he molekole bioactive koʻikoʻi a me ke kūlana kuhikuhi, loaʻa i ka 1-methylnicotinamide chloride nā manaʻolana noi ākea i ka noiʻi ʻepekema, ka hoʻomohala ʻana i nā lāʻau lapaʻau, a me ka ʻoihana mea hoʻohui meaʻai. ʻO kāna loiloi palekana i wehewehe pono ʻia a me nā hana olaola like ʻole e hoʻokumu iā ia he kumuhana waiwai nui no ka noiʻi a me kahi ʻāpana no nā noi like ʻole.
