Mea hana pauka CMS121 CAS No.: 1353224-53-9 98.0% maʻemaʻe min. no nā mea hoʻohui
Nā Palena Huahana
| Inoa huahana | CMS121 |
| Inoa ʻē aʻe | CMS-121; 1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-; 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121); ACC,AcetylCoACarboxylase,maʻi,neuroprotective,inhibit,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121 |
| Helu CAS. | 1353224-53-9 |
| ʻO ke ʻano molekole | C20H19NO3 |
| Kaumaha molekole | 321.37 |
| Maʻemaʻe | 98.0% |
| helehelena | Pauka melemele māmā |
| Noi | Mea Hoʻohui Meaʻai Maka |
Hoʻolauna huahana
ʻO 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol kahi hui i kapa ʻia ʻo CMS121. Hōʻike ka paʻakikī o ke ʻano o ka hui he mau waiwai kū hoʻokahi a me nā hoʻohana kūpono. No ka hoʻomaopopo ʻana i kona koʻikoʻi, kōkua ia i ka ʻike ʻana i nā hui hana e kū nei a kālailai i ko lākou hopena hiki. Hōʻike ka loaʻa ʻana o ke apo quinoline he hana biologically paha ka hui. Ua ʻike ʻia nā molekala i loaʻa mai Quinoline no ko lākou mau waiwai biological like ʻole, me nā hana antibacterial a me nā anti-inflammatory. Hiki i ka hoʻopili ʻana o ka hui cyclopentyloxy ke kōkua i ka solubility o ka hui a hoʻonui paha i kāna hana biological ma o nā hopena steric. I nā haʻawina ma nā cell HT22, ua hōʻike ʻo CMS-121 i nā hopena neuroprotective koʻikoʻi, e pale pono ana i kēia mau cell mai ka ischemia a me ka hōʻino oxidative. Eia kekahi, loaʻa iā CMS-121 nā waiwai anti-inflammatory koʻikoʻi, e hōʻike ana i kona hiki ke hoʻololi i nā pane inflammatory. Ma ka hana ʻana pēlā, hiki i ka CMS-121 ke hōʻemi i ka mumū i nā ʻiʻo a me nā ʻōpū like ʻole. He hana pharmacological ikaika ko CMS-121 ma ke ʻano he mea hoʻopale i ka acetyl-CoA carboxylase 1 (ACC1). ʻO kona hopena hoʻopale ikaika ma ACC1 e lilo ia i mea hoʻohiki maikaʻi.
Hiʻona
(1) Maʻemaʻe kiʻekiʻe: Hiki i ka CMS-121 ke loaʻa nā huahana maʻemaʻe kiʻekiʻe ma o nā kaʻina hana hana i hoʻomaʻemaʻe ʻia. ʻO ke ʻano o ka maʻemaʻe kiʻekiʻe ʻo ia hoʻi ka bioavailability maikaʻi a me nā hopena maikaʻi ʻole.
(2) Palekana: Palekana kiʻekiʻe, kakaikahi nā hopena maikaʻi ʻole.
(3) Paʻa: Loaʻa i ka CMS-121 ke kūpaʻa maikaʻi a hiki ke mālama i kāna hana a me ka hopena ma lalo o nā ʻano like ʻole a me nā kūlana mālama.
Nā noi
He hua quinolone derivative ka CMS-121 a he mea hoʻopaʻa waha no ka acetyl-CoA carboxylase 1 (ACC1) me nā waiwai pharmacological hoʻohiki. Ua hana ʻia nā noiʻi nui e noiʻi i nā pono kūpono o CMS-121 ma nā wahi like ʻole, me ka neuroprotection, nā hopena anti-inflammatory, ka hana antioxidant, a me kona hopena i nā māka e pili ana i ka ʻelemakule olakino.
