5-Amino-1-methylquinolinium iodide（NNMTi） CAS No.:42464-96-0 98.0% maʻemaʻe min. | mea hana mea hoʻohui
Nā Palena Huahana
| Inoa huahana | 5-Amino-1-methylquinolinium iodide（NNMTi） |
| Inoa ʻē aʻe | NNMTi5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE ʻO ka iodide 5-amino-1-methylquinolinium 5-Amino-1-methylquinolin-1-iumiodide 1-methylquinolin-1-ium-5-amine;iodide ʻO ka 5-Amino-1-methyl-1-quinolinium Iodide ʻO ka iodide 5-Amino-1-mq |
| Helu CAS. | 42464-96-0 |
| ʻO ke ʻano molekole | C10H11IN2 |
| Kaumaha molekole | 286.11 |
| Maʻemaʻe | 98.0% |
| helehelena | ʻEleʻele a ʻulaʻula paha |
| Hoʻopili ʻana | 1kg/ʻeke, 25kg/barela |
| Noi | Mea Hoʻohui Meaʻai Maka |
Hoʻolauna huahana
Ua ʻike hou ʻia ka enzyme cytosolic nicotinamide N-methyltransferase (NNMT) e hoʻoponopono i nā pae o nā precursors nicotinamide e pono ai no ka biosynthesis NAD+ a no laila he kuleana koʻikoʻi ia i ka hoʻoponopono ʻana i ke ala hoʻopakele NAD+ a me ka metabolism cellular. Hōʻike ʻia ʻo NNMT i loko o nā ʻiʻo skeletal, a piʻi mālie kona hōʻike ʻana me ka ʻelemakule ʻana o nā ʻiʻo. ʻO ka mea nui, ʻo NNMT kahi ʻāpana nui o ka hōʻailona hōʻike gene sarcopenic, a ʻo kona overexpression e alakaʻi i ka emi nui ʻana o nā pae NAD+ a me ka emi ʻana o ka nui o nā ʻiʻo, ka ikaika, a me ka hana e hele pū me ka ʻelemakule. ʻO ka mālama ʻana i nā ʻiole ʻelemakule me kahi mole liʻiliʻi NNMT inhibitor (NNMTi) i hoʻonui i ka proliferation, fusion, a me ka hiki ke hana hou o nā muSCs, no laila e hoʻomaikaʻi ana i ka hana hana o nā ʻiʻo skeletal. Ua loaʻa nā hopena like ma vitro me ka hoʻohana ʻana i nā cell C2C12, i like loa me nā muSCs, kahi i hoʻolaha ai ka mālama ʻana o NNMTi i ka hoʻokaʻawale ʻana o ka myoblast a kākoʻo i nā loli metabolic i nā metabolites cellular e pili ana me ke ala hoʻopakele NAD +.
ʻO NNMTi kahi enzyme i hoʻonui nui ʻia i ka wā ʻelemakule o nā ʻiʻo iwi a pili pū me ka hōʻino ʻia o ke ala NAD+, ka hana sirtuin1 dysregulated, a me ka hoʻonui ʻia o ka senescence o nā cell stem muscle. ʻO NNMT kahi enzyme metabolic e hoʻoulu ai i ka methylation o nicotinamide (NAM) me ka hoʻohana ʻana i ka universal methyl donor S-adenosylmethionine (SAM), e hoʻopili ana i ke kūlana metabolic o ke kelepona i ke kaulike methylation a me nā pae NAD+ intracellular. Hōʻike nui ʻia ʻo NNMT i loko o ke akepaʻa a me nā ʻiʻo adipose, a me nā kūlana pathological i hōʻailona ʻia e ka hoʻonui ʻia o nā koi metabolic, e like me kekahi mau maʻi ate momona a me ka maʻi diabetes. Pili ʻo NNMT i nā ʻano hana hoʻokaʻawale like ʻole, me ka hoʻololi ʻana o nā cell stem embryonic kanaka naive a oʻo, myogenesis, a me nā hoʻololi epithelial a me neuromesenchymal i nā maʻi kanesa like ʻole. Hoʻoponopono ʻia ka hōʻike ʻana o NNMT ma ke ʻano kikoʻī a me ka pōʻaiapili ma mua o kahi ʻano hoʻoponopono ubiquitous.
Hiʻona
(1) Maʻemaʻe kiʻekiʻe: Hiki i ka NNMTi ke loaʻa nā huahana maʻemaʻe kiʻekiʻe ma o nā kaʻina hana hana i hoʻomaʻemaʻe ʻia. ʻO ke ʻano o ka maʻemaʻe kiʻekiʻe ʻoi aku ka maikaʻi o ka bioavailability.
(2) Ke kuhikuhi ʻana: Hoʻopili pono ʻo NNMTi i ka enzyme NNMT a hiki ke kāohi pono i kāna hana, a laila e hoʻopilikia ana i ke ala metabolic o ka nicotinamide.
(3) Paʻa: Loaʻa i ka NNMTi ke kūpaʻa maikaʻi a hiki ke mālama i kāna hana a me ka hopena ma lalo o nā ʻano like ʻole a me nā kūlana mālama.
(4) Nā manaʻolana hoʻomohala: Ma muli o nā ʻano like ʻole o NNMTi, ua loaʻa i kona hoʻomohala ʻana ka nānā nui ʻia a he ākea ka noiʻi a me nā manaʻolana noi.
Nā noi
ʻO NNMTi (CAS 42464-96-0) kahi mea hoʻopaʻa nicotinamide N-methyltransferase (NNMT), kahi mea hoʻopaʻa ikaika (IC50=1.2 μM) o ka nicotinamide N-methyltransferase (NNMT) e hoʻolaha ana i ka hoʻokaʻawale ʻana o ka myoblast. Hoʻopaʻa koho ʻo NNMTi i nā koena kahua hoʻopaʻa substrate NNMT. Hoʻolaha ʻo NNMTi i ka hoʻokaʻawale ʻana o ka myoblast i loko o ka vitro a hoʻonui i ka hoʻohuihui ʻana o nā cell stem muscle a me ka hana hou ʻana i nā ʻiole ʻelemakule. ʻO NNMT kahi enzyme biotransformation cytosolic kumu e hoʻoulu ai i ka N-methylation o nā xenobiotics endogenous a me exogenous. Ke hoʻohālikelike ʻia me ka hoʻololi ʻana i ka ʻai lean wale nō, ʻo ka mālama ʻana o NNMT i hui pū ʻia me ka hoʻololi ʻana i ka ʻai lean i hoʻolalelale i ka hoʻomaikaʻi ʻana i ka pohō momona o ke kino, hoʻonui i ka ratio o ka nui o ke kino holoʻokoʻa i ke kaumaha o ke kino, hoʻemi i ke kaumaha o ka ʻiʻo adipose keʻokeʻo epididymal o ke ake, hoʻemi i ka waiho ʻana o ka momona o ke ake, a hoʻomaikaʻi i ka steatosis o ke ake. Eia kekahi, hiki i ka NNMTi ke hoʻonui i ka ikaika a hoʻolaha i ka hiki ke hana hou o ka ʻiʻo ʻelemakule, kahi mea pono no ka mālama ʻana i ka sarcopenia.
