CMS121 mea hana pauka CAS No.: 1353224-53-9 98.0% maemae min. no nā mea hoʻohui
Nā Kūlana Huahana
| inoa huahana | CMS121 |
| inoa ʻē aʻe | CMS-121; 1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-; 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121); ACC,AcetylCoenzymeACarboxylase,ma'i,neuroprotective,keakea,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121 |
| CAS No. | 1353224-53-9 |
| ʻAno molekala | C20H19NO3 |
| Kaumaha molekula | 321.37 |
| Maemae | 98.0% |
| Ka nana aku | ʻO ka pauka melemele māmā |
| Palapala noi | Mea ʻai meaʻai kumu |
Hoʻolauna huahana
ʻO 4-(4-(cyclopentyloxy)quinolin-2-yl) benzene-1,2-diol kahi pūhui i kapa ʻia ʻo CMS121. ʻO ka paʻakikī o ka hoʻokumu ʻana o ka pūhui e hōʻike ana he mau waiwai kūʻokoʻa paha kona a me ka hoʻohana ʻana. No ka hoʻomaopopo ʻana i kona koʻikoʻi, kōkua ia e ʻike i nā pūʻulu hana e kū nei a nānā i kā lākou hopena. ʻO ka loaʻa ʻana o ke apo quinoline e hōʻike ana i ka hana biologically o ka pūhui. Ua ʻike ʻia nā molekala i loaʻa mai i ka quinoline no kā lākou mau waiwai olaola like ʻole, me nā hana antibacterial a me nā anti-inflammatory. Hiki i ka hoʻopili ʻana o ka hui cyclopentyloxy ke kōkua i ka solubility o ka pūhui a i ʻole e hoʻonui i kāna hana olaola ma o nā hopena steric. I nā haʻawina ma nā pūnaewele HT22, ua hōʻike ʻo CMS-121 i nā hopena neuroprotective koʻikoʻi, e pale pono ana i kēia mau cell mai ka ischemia a me ka pōʻino oxidative. Eia kekahi, he mau waiwai anti-inflammatory koʻikoʻi ka CMS-121, e hōʻike ana i kona hiki ke hoʻololi i nā pane inflammatory. Ma ka hana ʻana pēlā, hiki i ka CMS-121 ke hōʻemi i ka ʻāʻī i loko o nā ʻiʻo a me nā ʻāpana like ʻole. Loaʻa i ka CMS-121 ka hana lāʻau lapaʻau ikaika ma ke ʻano he mea pale o ka acetyl-CoA carboxylase 1 (ACC1). ʻO kona hopena paʻa i ka ACC1 e lilo ia i mea hoʻohiki hoʻohiki.
Hiʻona
(1) Maʻemaʻe kiʻekiʻe: Hiki iā CMS-121 ke loaʻa nā huahana maʻemaʻe kiʻekiʻe ma o nā kaʻina hana hoʻomaʻemaʻe. ʻO ka maʻemaʻe kiʻekiʻe, ʻoi aku ka maikaʻi o ka bioavailability a me ka liʻiliʻi o nā hopena ʻino.
(2) Palekana: Palekana kiʻekiʻe, liʻiliʻi nā hopena ʻino.
(3) Paʻa: He kūpaʻa maikaʻi ka CMS-121 a hiki ke mālama i kāna hana a me ka hopena ma lalo o nā kaiapuni a me nā kūlana mālama.
Nā noi
ʻO CMS-121 kahi mea hoʻopaneʻe quinolone a me ka waha acetyl-CoA carboxylase 1 (ACC1) mea hoʻopaneʻe me nā waiwai pharmacological hoʻohiki. Ua mālama ʻia nā noiʻi nui e noiʻi i nā pono kūpono o CMS-121 ma nā wahi like ʻole, me ka neuroprotection, nā hopena anti-inflammatory, ka hana antioxidant, a me kona hopena i nā māka e pili ana i ka ʻelemakule olakino.
