YDL223C (HBT1) mea hana pauka CAS No.: 489408-02-8 99% maemae min. no nā mea hoʻohui

Hoʻopaʻa ʻia ka HBT1 i ka ligand-binding domain o ka α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) ma ke ʻano glutamate. ʻO ia ke ʻano o ka HBT1 he mole e hiki ke hoʻopaʻa wale i kahi pūnaewele kikoʻī ma ka protein AMPA-R ke loaʻa ka glutamate, a kōkua kēia paʻa i ka hoʻoponopono ʻana i ka hana o ka protein. Hōʻike ʻia nā mea hoʻokipa AMPA i loko o ka ʻōnaehana o ke kikowaena a hoʻokani i nā kuleana koʻikoʻi i ke kamaʻilio neuronal, ka hoʻoili ʻana i ka sensory, ke aʻo ʻana, ka hoʻomanaʻo, a me ka synaptic plasticity. ʻO nā mea loaʻa AMPA nā mea kōkua nui i ka neurotransmission excitatory, hoʻopā i ka wikiwiki, wikiwiki desensitizing excitation i nā synapses he nui, a komo i nā pane mua i ka glutamate ma nā wahi synaptic. Hōʻike pinepine ʻia nā mea loaʻa AMPA me nā mea loaʻa NMDA i nā synapses, a hui pū lākou e hāpai i nā kaʻina hana synaptic plasticity e pili ana i ke aʻo ʻana, hoʻomanaʻo, excitotoxicity, a me neuroprotection. ʻO ka brain-derived neurotrophic factor (BDNF) kahi mea neurotrophic e hana nui ana i ka mālama ʻana a me ka hoʻonui ʻana i nā neurons a he ikaika a nui nā hopena i ka hoʻonui ʻana, ka ʻokoʻa, ke ola a me ka make ʻana o nā pūnaewele neuronal a me nā mea ʻole. , he modulator neurotransmitter e kōkua ana i ka palaki neuronal i ke aʻo ʻana a me ka hoʻomanaʻo. No laila, he mea nui ia no ke olakino a me ka maikaʻi o ka ʻōnaehana nerve.