ʻO ka Calcium Alpha ketoglutarate (AKG) He metabolite waena ia o ka pōʻaiapuni waikawa tricarboxylic a komo i ka synthesis o nā waikawa amino, nā huaora a me nā waikawa organik a me ka metabolism ikehu. Hiki ke hoʻohana ʻia ma ke ʻano he mea hoʻohui meaʻai a he mau manaʻolana noi ākea. Ma waho aʻe o kāna mau hana olaola i loko o ke kino o ke kanaka, hoʻohana nui ʻia ka calcium alpha-ketoglutarate i ke kahua lāʻau lapaʻau a ua lilo ia i ʻāpana koʻikoʻi o nā huahana olakino a me nā hopena lapaʻau.
He aha ka alpha-ketoglutarate?
He metabolite waena kūlohelohe ʻo AKG i hana ʻia ma ke ʻano kūlohelohe, ʻo ia hoʻi, hana ko mākou kino ponoʻī ia mea. Hana pū ka ʻoihana hoʻohui i kahi mana synthetic i like ke kemika me AKG i hana maoli ʻia.
He aha ka hana a AKG?
He molekala ʻo AKG i komo i nā ala metabolic a me nā ala cellular he nui. Hana ia ma ke ʻano he mea hāʻawi ikehu, mea hoʻomākaukau no ka hana ʻana o nā waikawa amino a me ka molekala hōʻailona cell, a he mea hoʻololi i nā kaʻina hana epigenetic. He molekala koʻikoʻi ia i loko o ke kaʻina hana Krebs, e hoʻoponopono ana i ka wikiwiki holoʻokoʻa o ke kaʻina hana waikawa citric o ka meaola. Hana ia ma nā ala like ʻole i loko o ke kino e kōkua i ke kūkulu ʻana i nā ʻiʻo a kōkua i ka ho'ōla ʻana i nā ʻeha, ʻo ia kekahi o nā kumu i kaulana ai i ka honua bodybuilding.
Hana pū ʻo AKG ma ke ʻano he mea hoʻopau naikokene, e pale ana i ka nui o ka naikokene a pale i ka hōʻiliʻili ʻana o ka ammonia keu. He kumu maikaʻi nō hoʻi ia o ka glutamate a me ka glutamine, ka mea e hoʻoulu ai i ka hana ʻana o ka protein i loko o nā ʻiʻo a kāohi i ka hoʻohaʻahaʻa ʻana o ka protein.
Eia kekahi, hoʻoponopono ia i ka enzyme 10-11 translocation (TET) e pili ana i ka demethylation DNA a me ka lysine demethylase e loaʻa ana i ka Jumonji C domain, ʻo ia ka histone demethylase nui. Ma kēia ʻano, he mea nui ia i ka hoʻoponopono ʻana a me ka hōʻike ʻana o nā gene.
Hiki iā AKG ke hoʻopaneʻe i ka ʻelemakule?
Aia nā hōʻike e hiki iā AKG ke hoʻohuli i ka ʻelemakule, a ua hōʻike nā haʻawina he nui he ʻoiaʻiʻo kēia. Ua hōʻike ʻia kahi noiʻi 2014 ua hoʻolōʻihi ʻo AKG i ke ola o nā C. elegans makua ma kahi o 50% ma o ka pale ʻana i ka ATP synthase a me ka pahuhopu o rapamycin (TOR).
Ma kēia haʻawina, ua ʻike mākou ʻaʻole wale ʻo AKG e hoʻolōʻihi i ke ola akā hoʻopaneʻe pū kekahi i kekahi mau ʻano pili i ka makahiki, e like me ka nalowale ʻana o nā neʻe kino wikiwiki i hoʻonohonoho ʻia i maʻamau i nā C. elegans ʻelemakule. No ka hoʻomaopopo ʻana pehea e pili ai ʻo AKG i ka ʻelemakule, e wehewehe mākou i nā ʻano hana e kāohi ai ʻo AKG i ka ATP synthase a me TOR e hoʻolōʻihi i ke ola ma C. elegans a me nā ʻano ʻē aʻe paha.
Pehea e hana ai ka calcium alpha-ketoglutarate
ʻO ka mea mua, he kuleana koʻikoʻi ko ka calcium alpha-ketoglutarate i ka metabolism ikehu. Ma ke ʻano he huahana waena o ka pōʻaiapuni waikawa tricarboxylic (TCA cycle), komo ka calcium α-ketoglutarate i ke kaʻina hana ikehu intracellular. Ma o ke pōʻaiapuni TCA, ua hoʻopau ʻia a hoʻoheheʻe ʻia nā meaʻai e like me nā kalapona, nā momona, a me nā protein e hana i ka ATP (adenosine triphosphate) e hāʻawi i ka ikehu no nā cell. Ma ke ʻano he waena koʻikoʻi i ka pōʻaiapuni TCA, hiki i ka calcium α-ketoglutarate ke hoʻolaha i ka metabolism ikehu cell, hoʻonui i ka pae ikehu o ke kino, kōkua i ka hoʻoikaika ʻana i ka ikaika kino a me ke ahonui, a hoʻomaikaʻi i ka luhi kino.
ʻO ka lua, he kuleana koʻikoʻi ko ka calcium α-ketoglutarate i ka metabolism amino acid. ʻO nā waikawa Amino nā ʻāpana kumu o ka protein, a pili ka calcium α-ketoglutarate i ka hoʻololi a me ka metabolism o nā waikawa amino. I ke kaʻina hana o ka hoʻololi ʻana i nā waikawa amino i nā metabolites ʻē aʻe, transaminates ka calcium α-ketoglutarate me nā waikawa amino e hana i nā waikawa amino hou a i ʻole nā waikawa α-keto, no laila e hoʻoponopono ana i ke kaulike a me ka hoʻohana ʻana o nā waikawa amino. Eia kekahi, hiki i ka calcium α-ketoglutarate ke lawelawe ma ke ʻano he substrate oxidation no nā waikawa amino, komo i ka metabolism oxidative o nā waikawa amino, a hana i ka ikehu a me ke kalapona dioxide. No laila, he mea nui ka calcium α-ketoglutarate i ka mālama ʻana i ka homeostasis o nā waikawa amino a me ka metabolism protein i loko o ke kino.
Eia kekahi, hana ka calcium alpha-ketoglutarate ma ke ʻano he antioxidant e hoʻopau i nā radical manuahi a pale i nā cell mai ka pōʻino oxidative. I ka manawa like, hiki i ka calcium α-ketoglutarate ke hoʻoponopono i ka hana o ka ʻōnaehana pale, paipai i ka hoʻoulu ʻana a me ka hoʻonui ʻana o nā cell pale, a hoʻoikaika i ke kūʻē ʻana o ke kino i nā maʻi a me ka maʻi. No laila, he mea nui ka calcium α-ketoglutarate i ka mālama ʻana i ke kaulike o ke kino a me ke kūʻē ʻana i nā maʻi.
Noiʻi e pili ana i nā hopena o ka calcium α-ketoglutarate i ka ʻelemakule
Hoʻopilikia ka ʻelemakule iā kākou āpau a he kumu pilikia ia no nā maʻi he nui, a e like me ka demographics o ka ʻoihana Medicare, piʻi ka likelika o ka maʻi me ka makahiki.
He metabolite koʻikoʻi ka calcium alpha-ketoglutarate i loko o ko mākou kino, i ʻike ʻia no ke kuleana o ke kelepona i loko o ke kaʻina hana Krebs, kahi kaʻina hana e pono ai no ka hoʻoheheʻe ʻia ʻana o nā waikawa momona a me nā waikawa amino, e ʻae ana i ka mitochondria e hana i ka ATP (ʻo ATP ke kumu ikehu o nā kelepona).
ʻO ia ka mea e pili ana i ka hoʻouka ʻana o ke kaʻina hana calcium alpha-ketoglutarate, no laila hiki ke hoʻololi ʻia ka calcium alpha-ketoglutarate i glutamate a laila i loko o glutamine, hiki ke kōkua i ka hoʻoulu ʻana i ka synthesis o ka protein a me ka collagen (ʻo ka collagen kahi protein fibrous A e hana ana i ka 1/3 o nā protein āpau i ke kino a kōkua i ke kākoʻo ʻana i ka iwi, ka ʻili a me ke olakino ʻiʻo).
ʻO ka Calcium α-ketoglutarate, ma ke ʻano he mea hoʻohui meaʻai multifunctional, he nui nā manaʻolana no ka hoʻohana ʻana i nā huahana mālama ola. ʻO kāna mau hana olaola like ʻole e like me ka antioxidant, anti-aging, immune regulation a me ka amino acid metabolism e lilo ia i mea hana ikaika e hoʻomaikaʻi ai i ke olakino kanaka. Me ka hoʻonui ʻana o ka ʻike i ka mālama ola a me ka hoʻoikaika ʻana i ka noiʻi ʻepekema, ua manaʻoʻiʻo ʻia e loaʻa hou aku ka nānā a me ka hoʻomohala ʻana i ka hoʻohana ʻana o ka α-ketoglutarate calcium ma ke kahua o nā huahana mālama ola.
ʻŌlelo Hoʻokuʻu: No ka ʻike laulā wale nō kēia ʻatikala a ʻaʻole pono e wehewehe ʻia he ʻōlelo aʻoaʻo lapaʻau. Loaʻa kekahi o nā ʻike o ka pou blog mai ka Pūnaewele a ʻaʻole ia he ʻoihana. ʻO kēia pūnaewele wale nō ke kuleana no ka hoʻokaʻawale ʻana, ka hoʻoponopono ʻana a me ka hoʻoponopono ʻana i nā ʻatikala. ʻO ke kumu o ka lawe ʻana i ka ʻike hou aku, ʻaʻole ia he manaʻo ua ʻae ʻoe i kona mau manaʻo a hōʻoia paha i ka ʻoiaʻiʻo o kāna ʻike. E kūkākūkā mau me kahi loea mālama ola ma mua o ka hoʻohana ʻana i nā mea hoʻohui a i ʻole ka hana ʻana i nā hoʻololi i kāu papa mālama ola.
Ka manawa hoʻouna: ʻOkakopa-15-2024
