No ke aha he mea nui ka Alpha Ketoglutarate Magnesium no kou olakino

Calcium Alpha ketoglutarate (AKG) he metabolite waena o ka pōʻaiapuni tricarboxylic a komo i ka synthesis o nā waikawa amino, nā huaora a me nā waikawa organik a me ka metabolism ikehu. Hiki ke hoʻohana ʻia ma ke ʻano he meaʻai meaʻai a loaʻa nā manaʻo ākea ākea. Ma kahi o kāna mau hana olaola i loko o ke kino kanaka, hoʻohana nui ʻia ka calcium alpha-ketoglutarate i ka lāʻau lapaʻau a ua lilo ia i mea nui o nā huahana olakino a me nā hoʻonā olakino.

He aha ka alpha-ketoglutarate?

ʻO AKG kahi metabolite intermediary endogenous kūlohelohe i ʻāpana o ka pōʻai Krebs, ʻo ia hoʻi ka hana ʻana o ko mākou kino ponoʻī. Hoʻopuka pū ka ʻoihana hoʻohui i kahi mana synthetic i like me ka AKG i hana maoli ʻia.

He aha ka hana a AKG?

ʻO AKG kahi mole e pili ana i nā ala metabolic a me ke kelepona. He mea hāʻawi i ka ikehu, precursor no ka hana ʻana i ka waikawa amino a me ka molekele hōʻailona cell, a he modulator o nā kaʻina epigenetic. He mole koʻikoʻi ia i ka pōʻai Krebs, e hoʻoponopono ana i ka holo holoʻokoʻa o ka pōʻai citric acid o ke kino. Hana ia ma nā ala like ʻole o ke kino e kōkua i ke kūkulu ʻana i ka ʻiʻo a kōkua i ka ho'ōla ʻana i ka ʻeha, ʻo ia kekahi o nā kumu kaulana i ka honua bodybuilding.

Ke hana pū nei ʻo AKG ma ke ʻano he mea hoʻoheheʻe nitrogen, pale i ka hoʻonui ʻana o ka nitrogen a pale i ke kūkulu ʻana i ka nui o ka amonia. He kumu maikaʻi loa ia o ka glutamate a me ka glutamine, ka mea e hoʻoulu ai i ka synthesis protein i nā ʻiʻo a keʻakeʻa i ka hōʻino ʻana o ka protein.

Eia kekahi, hoʻoponopono ia i ka 10-11 translocation (TET) enzyme i komo i ka DNA demethylation a me ka Jumonji C domain-containing lysine demethylase, ʻo ia ka histone demethylase nui. Ma kēia ala, he mea pāʻani koʻikoʻi ia i ka hoʻoponopono gene a me ka ʻōlelo.

Hiki iā AKG ke hoʻopaneʻe i ka ʻelemakule?

Aia nā hōʻike e hiki i ka AKG ke hoʻoikaika i ka ʻelemakule, a ua hōʻike nā haʻawina he nui kēia. Ua hōʻike ʻia kahi haʻawina 2014 ua hoʻolōʻihi ʻia ka AKG i ke ola o nā mākua C. elegans ma kahi o 50% ma ke kāohi ʻana i ka ATP synthase a me ka pahuhopu o rapamycin (TOR).

Ma kēia noiʻi ʻana, ʻike mākou ʻaʻole i hoʻolōʻihi ʻia ke ola o AKG akā ke hoʻopaneʻe nei i kekahi mau phenotypes pili makahiki, e like me ka nalo ʻana o nā neʻe kino i hui pū ʻia me ka maʻamau i nā makahiki C. elegans. No ka hoʻomaopopo ʻana i ka pili ʻana o AKG i ka ʻelemakule, e wehewehe mākou i nā ʻano hana a AKG e kāohi ai i ka ATP synthase a me TOR e hoʻolōʻihi i ke ola ma C. elegans a me nā ʻano ʻē aʻe paha.

Pehea ka hana ʻana o ka calcium alpha-ketoglutarate

ʻO ka mea mua, he mea nui ka calcium alpha-ketoglutarate i ka metabolism ikehu. Ma ke ʻano he huahana waena o ka tricarboxylic acid cycle (TCA cycle), ke komo nei ka calcium α-ketoglutarate i ke kaʻina hana o ka ikehu intracellular. Ma o ka pōʻaiapuni TCA, ua hoʻoheheʻe ʻia nā meaʻai e like me ka carbohydrates, nā momona, a me nā protein e hoʻohua ai i ka ATP (adenosine triphosphate) e hāʻawi i ka ikehu no nā cell. Ma ke ʻano he koʻikoʻi koʻikoʻi i ka pōʻai TCA, hiki i ka calcium α-ketoglutarate ke hoʻoikaika i ka metabolism ikehu cell, hoʻonui i ka pae ikehu o ke kino, kōkua i ka hoʻoikaika kino kino a me ka hoʻomanawanui, a hoʻomaikaʻi i ka luhi kino.

ʻO ka lua, he mea nui ka calcium α-ketoglutarate i ka metabolism amino acid. ʻO nā amino acids nā ʻāpana kumu o ka protein, a ua komo ka calcium α-ketoglutarate i ka hoʻololi ʻana a me ka metabolism o nā waikawa amino. I ke kaʻina hana o ka hoʻololi ʻana i nā waikawa amino i nā metabolites ʻē aʻe, hoʻololi ka calcium α-ketoglutarate me nā waikawa amino e hana i nā waikawa amino hou a i ʻole α-keto acids, pēlā e hoʻoponopono ai i ke koena a me ka hoʻohana ʻana i nā waikawa amino. Eia kekahi, hiki i ka calcium α-ketoglutarate ke lawelawe ma ke ʻano he substrate oxidation no nā amino acids, komo i ka metabolism oxidative o nā amino acids, a hana i ka ikehu a me ka carbon dioxide. No laila, he mea nui ka calcium α-ketoglutarate i ka mālama ʻana i ka homeostasis o nā waikawa amino a me ka metabolism protein i ke kino.

Eia kekahi, hana ka calcium alpha-ketoglutarate ma ke ʻano he antioxidant e hōʻemi ana i nā radical manuahi a pale i nā cell mai ka pōʻino oxidative. I ka manawa like, hiki i ka calcium α-ketoglutarate ke hoʻoponopono i ka hana o ka ʻōnaehana pale, hoʻoikaika i ka hoʻoulu ʻana a me ka hoʻonui ʻana o nā cell immune, a hoʻonui i ke kūʻē o ke kino i ka maʻi a me ka maʻi. No laila, he koʻikoʻi nui ka calcium α-ketoglutarate i ka mālama ʻana i ka pale pale pale o ke kino a me ka pale ʻana i nā maʻi.

Ka noiʻi e pili ana i ka hopena o ka calcium α-ketoglutarate i ka wā ʻelemakule

Hoʻopilikia ka ʻelemakule iā mākou a pau a he kumu pilikia ia no nā maʻi he nui, a e like me ka ʻoihana Medicare demographics, piʻi ka nui o ka maʻi me ka makahiki.

ʻO ka calcium alpha-ketoglutarate kahi metabolite koʻikoʻi i loko o ko mākou kino, i ʻike ʻia no ke kuleana o ka cell i ka pōʻai Krebs, kahi pōʻai pono no ka hoʻoheheʻe ʻana o nā momona momona a me nā waikawa amino, e ʻae ai i ka mitochondria e hana i ka ATP (ʻo ATP ke kumu ikehu o nā cell).

ʻO ka mea e pili ana i ka hoʻouka ʻana o ka calcium alpha-ketoglutarate kaʻina, no laila hiki ke hoʻololi ʻia ka calcium alpha-ketoglutarate i glutamate a laila i glutamine, hiki ke kōkua i ka hoʻoulu ʻana i ka synthesis o ka protein a me ka collagen (ʻo ka collagen he A fibrous protein e hana i ka 1/3. o nā pūmua a pau i loko o ke kino a kōkua i ke kākoʻo ʻana i ka iwi, ka ʻili a me ke olakino ʻiʻo).

ʻO ka calcium α-ketoglutarate, ma ke ʻano he meaʻai meaʻai multifunctional, loaʻa nā manaʻo ākea ākea i nā huahana mālama olakino. ʻO kāna mau hana olaola like ʻole e like me antioxidant, anti-aging, immune regulation a me amino acid metabolism e lilo ia i mea ikaika e hoʻomaikaʻi ai i ke olakino kanaka. Me ka hoʻonui ʻana i ka ʻike o ka mālama olakino a me ka hohonu o ka noiʻi ʻepekema, ua manaʻo ʻia ʻo ka noi ʻana o ka calcium α-ketoglutarate i ke kula o nā huahana mālama olakino e loaʻa hou ka nānā a me ka hoʻomohala ʻana.