ʻO 7,8-Dihydroxyflavone (7,8-DHF) he flavonoids kūlohelohe e hōʻike ana i ka ʻōlelo hoʻohiki ma nā wahi like ʻole o ke olakino. Inā makemake ʻoe i nā mea hoʻohui kūlohelohe a i ʻole nā meaʻai meaʻai e kākoʻo ai i ke olakino lolo, naʻau, a me ka maikaʻi holoʻokoʻa, pono paha ka 7,8-DHF e ʻimi. ʻO ka 7,8-Dihydroxyflavone Powder i hāʻawiʻia e Suzhou Myland he helu CAS o 38183-03-8 a me ka maʻemaʻe a hiki i ka 98%. Ua loaʻa ka huahana i ka mana koʻikoʻi o ka maikaʻi a me ka hoʻokō ʻana i nā kūlana honua, e hōʻoia ana i ka pono a me ka palekana o ka huahana. , kūpono no ka noiʻi ʻepekema, ka hoʻomohala ʻana i ka lāʻau lapaʻau, ka hana ʻana i nā huahana mālama olakino a me nā māla ʻē aʻe, hāʻawi iā ʻoe i kahi koho hilinaʻi.
7,8-Dihydroxyflavone (7,8-DHF)he pūhui flavonoid kakaʻikahi e kū maoli ana ma ke ʻano. Ua ʻike ʻia ma Astragalus pumila, Primula grandifolia a me Hubei crabapple. ua puka mai ma ke ʻano he pūhui nootropic maikaʻi. Ua hōʻike ʻo ia i kahi ʻano o nā hopena neuropharmacological i nā haʻawina preclinical,
ʻO Flavonoids kahi papa o nā pūhui polyphenolic i loaʻa i nā ʻano huaʻai, nā mea kanu, a me nā kumu mea kanu ʻē aʻe. I nā makahiki i hala iho nei, ua loaʻa iā lākou ka manaʻo nui ma muli o kā lākou antioxidant, anti-inflammatory, a me nā waiwai neuroprotective.
Ua hōʻike ʻia kēia mau pūhui i nā hopena maikaʻi ma ka lolo, me ka hoʻonui ʻana i ka hana cognitive a me ka pale ʻana i nā maʻi neurodegenerative. ʻO 7,8-DHF kekahi o nā pūhui polyphenolic koʻikoʻi e loaʻa ana ka manaʻo nui e like me ka nootropic. Ua aʻo ʻia no kona mau hopena i ke ʻano, ka hoʻomanaʻo, ke aʻo ʻana, ka hopohopo, a me nā hana cognitive ʻē aʻe.
ʻO nā hopena neurological o 7,8-DHF i manaʻoʻia e hoʻopiliʻia e kona pilina me nā mea loaʻa kūikawā. Ua ʻike ʻia ʻo ia ʻo TrkA, kahi mea loaʻa i loko o ka hōʻailona ulu ʻana o ke aʻalolo a koʻikoʻi no ke ola neuronal a me ka plasticity.
Hana ʻo 7,8-DHF ma ka hoʻoponopono ʻana i ka hōʻike ʻana o nā mea loaʻa like ʻole, me nā subunits receptor glutamate a me BDNF. Hoʻopili ia i ka hoʻokumu ʻana o ka synapse, ka metabolism ikehu, a me ka hoʻokuʻu ʻana o ka acetylcholine i kekahi mau wahi lolo.
Eia kekahi, ʻike ʻia ka osteoporosis ʻo "silent killer" o ke kino kanaka, hoʻoweliweli koʻikoʻi i ke olakino o ka poʻe waena a me ka poʻe ʻelemakule, ʻoi aku ka nui o nā wahine postmenopausal. Ma lalo o nā kūlana physiological maʻamau, ʻo ka hoʻoponopono hou ʻana o ka iwi i kahi kūlana kaulike; akā, inā ʻaʻohe kaulike ma waena o ka hoʻokumu ʻia ʻana o ka iwi osteoblast-mediated a me ka hoʻihoʻi ʻana o ka iwi osteoclast, a ʻaʻole lawa ka nui o ka iwi i hoʻohui ʻia i ka nui o ka iwi i hoʻopaʻa ʻia, e emi ana ka nui o ka iwi. , ua luku ʻia ka microstructure o ka ʻiʻo iwi, e kumu ai ka osteoporosis.
ʻO 7,8-Dihydroxyflavone (7,8-DHF) he flavonoids i loaʻa i ka mea kanu e hiki ke hoʻohālike i ka hana o ka brain-derrived neurotrophic factor (BDNF), e hoʻoulu i ka dimerization o nā mea hoʻokipa TrkB a hoʻoulu i kāna mau molekala hōʻailona lalo. Ua hōʻike nā haʻawina e hiki i ka BDNF ke hoʻoikaika i ka ʻokoʻa osteoblast a me ka neʻe ʻana a me ka hoʻolalelale i ka ho'ōla ʻana.
Hiki i ka 7,8-DHF ke hoʻoikaika i ka hoʻonui a me ka hoʻokaʻawale ʻana o nā osteoblasts ma o ka launa pū ʻana me TrkB a me ka hoʻoulu ʻana i ke ala hōʻailona Wnt / β-catenin, a hiki ke kāohi i ka hana o nā osteoclast ma ka hoʻohaʻahaʻa ʻana i ka transcription factor c-fos; Eia kekahi, hiki i ka 7,8-DHF ke hoʻomaikaʻi i ka osteoporosis phenotype i nā ʻiole ovariectomized.
ʻO ke kinona a me nā waiwai o 7,8-dihydroxyflavone
Loaʻa iā ia nā hui hydroxyl ʻelua ma ke apo benzene a me hoʻokahi pūʻulu hydroxyl ma ke apo pyrrolone. E nānā pono kākou i ke ʻano kemika o 7,8-dihydroxyflavone:
ʻO ka molecular formula o 7,8-DHF ʻo C15H10O5, e hōʻike ana he 15 mau ʻātoma kalapona, 10 mau ʻātoma hydrogen, a me 5 mau ʻātoma oxygen.
ʻO 7,8-Dihydroxyflavone he paʻa kalamele melemele me ke kaumaha molekala o 286.24 g / mol. Hiki ke hoʻoheheʻe ʻia i ka wai no ka nui o nā pūʻulu hydroxyl hiki ke hoʻopaʻa i ka hydrogen i nā molekole wai.
7,8-DHF ka hana o ka hana: hoʻoponopono BDNF a me ka hoʻoulu ʻana o ka mea hoʻokipa Trkb
Ma keʻano o ka hana o ka hana, uaʻikeʻiaʻo 7,8-DHF e hoʻoikaika i ka hanaʻana o BDNF (ka mea neurotrophic i loaʻa i ka lolo) ma o ka hoʻopaʻaʻana a me ka hoʻouluʻana i kāna mea hoʻokipa TrkB. Me ka loaʻa ʻole o ka ʻenehana, alakaʻi kēia i kahi cascade o nā hana cellular e pono ai i ka mālama ʻana i ka hana neuronal kūpono a me ka hoʻolaha ʻana i ka neurogenesis.
E nānā pono kākou i ke ʻano hana nui o 7,8-DHF ma lalo nei.
ʻO ke kumu neurotrophic i loaʻa i ka lolo (BDNF) a me kāna kuleana i ka neuroplasticity
Me ka ʻike ʻana ua hoʻemi ʻia ka ʻōlelo neurotrophic factor (BDNF) i loaʻa i ka lolo i nā maʻi neurodegenerative, ʻo ia hoʻi ka maʻi o Alzheimer (AD), ʻo kona koʻikoʻi i ka mālama ʻana a me ka hoʻomaikaʻi ʻana i ke olakino lolo. .
He mea koʻikoʻi ka BDNF no nā hana neuronal like ʻole e hoʻolaha ana i ka hoʻoili synaptic, synaptogenesis, a me synaptic plasticity ma o ka hōʻailona ʻana me nā mea loaʻa TrkB. Hoʻolilo kēia i ke ala hōʻailona BDNF-TrkB i pahuhopu hoʻohiki no ka hoʻomohala ʻana i nā hana therapeutic e pili ana i ka hakakā ʻana i nā maʻi neurodegenerative.
Ua ʻimi nā haʻawina hou i nā pono kūpono o ka mole liʻiliʻi ʻo TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) i ka hoʻēmi ʻana i nā hopena mua o ka maʻi pili pili AD. Ma ke aʻo ʻana i ke ʻano kiʻi 5xFAD o AD, ua mālama ʻia nā ʻiole me 7,8-DHF no ʻelua mahina e hoʻomaka ana i hoʻokahi mahina o ka makahiki.
Hōʻike nā hopena o kēia noiʻi i ka hiki o ka therapeutic o 7,8-DHF i ka hoʻoponopono ʻana i nā hoʻololi neurochemical pili AD a me nā hōʻailona pathological. ʻO ka mea nui, ʻo ka mālama ʻana i ka 7,8-DHF ka mea i hoʻemi ʻia ka cortical Aβ plaque deposition, kahi hōʻailona nui o AD.
Eia kekahi, pale ia i nā neurons cortical mai ka hōʻemi ʻana i ka paʻakikī dendritic arbor, e kōkua ana i ka mālama ʻana i ke ʻano neuronal holoʻokoʻa. Akā naʻe, ʻaʻole ia i hoʻopilikia nui i ka dendritic spine density.
Wahi a Aytan, Nurgul a me nā mea ʻē aʻe, ua hōʻike pū ka mālama ʻana i nā hopena neuroprotective i ka hippocampus, ka pale ʻana i nā kiʻekiʻe kiʻekiʻe o nā pūhui choline-containing a attenuating glutamate loss.
Tropomyosin receptor kinase B (Trkb) alaloa hōʻailona hōʻailona
Ma 2010, ua hōʻike ka hui o Professor Ye Keqiang o ke Kulanui o Emory no ka manawa mua ma ka Proceedings of the National Academy of Sciences (PNAS) hiki ke hoʻohana ʻia ʻo 7,8-DHF ma ke ʻano he agonist mole liʻiliʻi o ka tropomyosin receptor kinase B ( ʻO TrkB), hiki ke hoʻohālikelike ʻO ka hana o ka brain-derived neurotrophic factor (BDNF) e hoʻāla hou i nā ala hōʻailona ma lalo o TrkB, e like me MAPK/ERK, PI3K/Akt a me PKC. Eia kekahi, ua ʻike ʻia nā haʻawina ma hope e hiki i ka 7,8-DHF ke hoʻohaʻahaʻa i ka momona momona i hoʻokomo ʻia i ka momona i nā ʻiole wahine ma o ka hoʻoulu ʻana i ka muscle skeletal TrkB, e hōʻike ana i nā ʻokoʻa kāne nui.
Hiki i ka brain-derived neurotrophic factor (BDNF) ke hoʻoikaika i ka hoʻokaʻawale osteoblast, ka neʻe ʻana a me ka ho'ōla ʻana i ka haʻihaʻi. He lālā ʻo BDNF o ka ʻohana neurotrophic factor a hoʻoponopono i nā ʻano hana olaola like ʻole ma ka hoʻopaʻa ʻana i ka transmembrane receptor tyrosine kinase B (TrkB). Eia nō naʻe, ʻo ka hōʻailona TrkB i hoʻokomo ʻia e BDNF he transient ma 10 min a piʻi i ka 60 min. Eia naʻe, he pōkole ka hapalua o ke ola o BDNF a ʻaʻole hiki ke hele maʻalahi i ka pale koko-lolo.
ʻO 7,8-dihydroxyflavone (7,8-DHF) he flavonoids i loaʻa i ka mea kanu i hiki ke lanakila i nā palena i luna o BDNF a ua ʻike ʻia ʻo ia he mimetic BDNF hana a hoʻohana ʻia i kēia manawa i nā ʻōnaehana biochemical a me nā kelepona. hiki iā ia ke hoʻoulu i ka dimerization TrkB a hoʻōla i kāna mau molekele hōʻailona lalo.
He kuleana koʻikoʻi ka loaʻa ʻana o ka tropomyosin receptor kinase B (TrkB) i ka hoʻopili ʻana i nā hopena o BDNF ma nā neurons. Ma ke ʻano he transmembrane tyrosine kinase receptor, ʻo TrkB ka mea loaʻa mua no BDNF a hoʻomaka i kahi cascade o nā hanana hōʻailona intracellular ma ka hoʻopaʻa ʻana i nā mea neurotrophic.
Hoʻoikaika ka BDNF i ka TrkB e hoʻoulu i nā ala intracellular nui, me ka phosphatidylinositol 3-kinase (PI3K) -Akt, mitogen-activated protein kinase (MAPK) -extracellular signal-regulated kinase (ERK), a me ka phospholipase Cγ (PLCγ) -protein kinase C ( PKC) alahele. Hāʻawi kēlā me kēia ala i kahi ʻano ʻokoʻa o ka hana neuronal a me ka maikaʻi.
He mea koʻikoʻi ke ala PI3K-Akt no ka hoʻolaha ʻana i ke ola neuronal a me ka pale ʻana i ka apoptosis. Hoʻoikaika ka hōʻailona BDNF-TrkB i kēia ala e hoʻonui ai i ke ola o ka cell ma ke kāohi ʻana i nā mea pro-apoptotic a me ka hoʻoulu ʻana i nā mea anti-apoptotic, no laila e hōʻoia i ka mālama ʻana i nā neurons olakino.
Ma ka ʻaoʻao ʻē aʻe, he kuleana koʻikoʻi ke ala MAPK-ERK i ka ʻokoʻa neuronal a me ka hoʻonui. Hoʻoikaika ka hōʻailona BDNF-TrkB i ka hoʻāla ʻana o ke ala MAPK-ERK, a ʻo ia hoʻi e kākoʻo i ka maturation neuronal a me ka ʻokoʻa a me kā lākou hoʻohui ʻana i nā pūnaewele neuronal e kū nei.
He mea koʻikoʻi ke ala PLCγ-PKC no ka hoʻoponopono ʻana i ka synaptic plasticity, kahi kaʻina kumu o ke aʻo ʻana a me ka hoʻomanaʻo. Hoʻololi ka hōʻailona BDNF-TrkB i ka hana o kēia ala, e alakaʻi ana i nā loli i ka ikaika synaptic a me ka pilina.
Hoʻolaha kēia modulation i ka hoʻololi ʻana a me ka hoʻonohonoho hou ʻana o nā neural circuits i pane i nā ʻike hou a me nā hoʻoulu ʻana i ka kaiapuni.
Nā waiwai neuroprotective
Hōʻike nā noiʻi e pale ana kēia flavonoid i nā neurons mai ke kaumaha oxidative a me ka apoptosis (programmed cell death). ʻO ke koʻikoʻi oxidative kahi mea nui i nā maʻi neurodegenerative e like me ka maʻi Alzheimer a me ka maʻi Parkinson. Ma ka scavenging free radicals a hōʻemi i ka pōʻino oxidative, hiki i ka 7,8-DHF ke kōkua i ka pale ʻana i ka pono neuronal a me ka hana.
I nā haʻawina holoholona, ua hōʻike ʻia ʻo 7,8-DHF e hoʻomaikaʻi i ka hana cognitive a me ka hoʻomanaʻo. No ka laʻana, i nā hiʻohiʻona o ka maʻi o Alzheimer, ua hōʻike ʻia ʻo 7,8-DHF e hoʻonui i ka synaptic plasticity, he mea koʻikoʻi no ke aʻo ʻana a me ka hoʻomanaʻo. Mechanism o ka hana
Ka hopena anti-inflammatory
Ma waho aʻe o kāna mau neuroprotective, 7,8-dihydroxyflavone kekahi mau hopena anti-inflammatory. ʻO ka maʻi maʻamau kahi hiʻohiʻona maʻamau o nā maʻi he nui, me nā maʻi neurodegenerative. Ma ka hoʻololi ʻana i nā ala inflammatory, hiki i ka 7,8-DHF ke kōkua i ka hōʻemi ʻana i ka neuroinflammation, i pili pinepine ʻia me ka emi ʻana o ka cognitive.
Nā waiwai Antioxidant: ROS scavenging a me ka lipid peroxidation
Loaʻa i ka 7,8-DHF nā waiwai antioxidant e like me ka mea i hōʻike ʻia e kona hiki ke scavenge reactive oxygen species (ROS) a hōʻemi i ka lipid peroxidation. Hāʻawi kēia mau hopena i kāna mau hopena neuroprotective ma o ka hoʻohaʻahaʻa ʻana i ka pōʻino neuronal oxidative stress-induced a me ka dysfunction.
Ua hōʻike nā haʻawina i ka 7,8-DHF ke kāohi i ka hana ʻana o nā cytokines pro-inflammatory a hoʻemi i ka hoʻoulu ʻana o microglia, nā cell immune i loko o ka ʻōnaehana nerve waena. ʻAʻole pale wale kēia hopena anti-inflammatory i nā neurons akā hana pū kekahi i kahi ʻoi aku ka maikaʻi no ka hana cognitive.
Hāʻawi ʻia i kāna mau hopena maikaʻi i ke olakino lolo, 7,8-dihydroxyflavone hiki ke hoʻohana ʻia i nā wahi like ʻole o ke olakino a me ka lāʻau lapaʻau. ʻO kekahi o nā noi kaulana loa:
Hoʻohui hoʻomanaʻo a hoʻihoʻi
Ua ʻike ʻia ʻo 7,8-DHF e hoʻomaikaʻi i ka hoʻohui ʻana i ka hoʻomanaʻo a me ka hoʻihoʻi ʻana i nā hana aʻo a me nā hana hoʻomanaʻo e pili ana i ka hippocampal i nā ʻano rodent. Hōʻike kēia mau ʻike i ka 7,8-DHF he nootropic hoʻohiki no ka hoʻomaikaʻi ʻana i ka hana hoʻomanaʻo i nā kānaka olakino a me ka poʻe me ka hoʻomanaʻo hoʻomanaʻo.
Synaptic plasticity: potentiation lōʻihi a me ke kaumaha
E like me ka mea i ʻōlelo ʻia ma mua, ua hōʻike ʻia ʻo 7,8-DHF e hoʻololi i ka synaptic plasticity ma o ka hoʻolaha ʻana i ka LTP a me ka hōʻemi ʻana i ka LTD i ka hippocampus. Manaʻo ʻia kēia mau hopena e hoʻopili ʻia e kona hiki ke hoʻāla i nā mea loaʻa TrkB a hoʻonui i ke ala hōʻailona BDNF.
Hāʻawi kēia modulation o synaptic plasticity i ka hoʻomaikaʻi ʻana i ka hana cognitive i ʻike ʻia ma hope o ka hoʻokele 7,8-DHF.
Hoʻonui ʻike
E like me ka mea i ʻōlelo ʻia ma mua, hōʻike ʻo 7,8-DHF i ka hiki ke hoʻonui i ka hana cognitive a me ka hoʻomanaʻo. He moho kēia no nā mea hoʻohui i manaʻo ʻia e hoʻomaikaʻi i ka hana noʻonoʻo, ʻoi aku hoʻi i ka poʻe ʻelemakule a i ʻole nā kānaka me ka emi ʻana o ka cognitive.
Absorption, Distribution, Metabolism, and Excretion (ADME): Hōʻike ka 7,8-DHF i nā waiwai pharmacokinetic maikaʻi, me ka wikiwiki o ka absorption, ākea ākea, a me ke komo ʻana o ka lolo. Hoʻopili mua ʻia ia e ke akepaʻa, me ka hapa nui o ka hui i hoʻokuʻu ʻia i loko o nā feces a me kahi mea liʻiliʻi i hoʻokuʻu ʻia i ka mimi.
ʻO ka pale ʻana i ke koko-lolo a me ka ʻili o ka lolo. ʻO kekahi o nā hiʻohiʻona nui o 7,8-DHFʻO kona hiki ke hele i ka pale koko-lolo (BBB) a komo i ka ʻiʻo o ka lolo, he mea koʻikoʻi i kona pono e like me ka nootropic.
Preclinical Safety Profile - Acute and Chronic Toxicity Studies: Ua hōʻike nā haʻawina palekana preclinical i ka 7,8-DHF he kūlana palekana maikaʻi, ʻaʻohe hopena koʻikoʻi i ʻike ʻia i nā haʻawina ʻona a me ka maʻi mau i nā rodents. Eia nō naʻe, koi ʻia ka loiloi palekana hou aʻe, me nā haʻawina i nā holoholona kiʻekiʻe a me nā kumuhana kanaka, e hoʻoholo i kona palekana no ka hoʻohana ʻana i ka lāʻau lapaʻau.
ʻOiai ua hōʻike nā haʻawina preclinical i ka 7,8-DHF i kahi kūlana palekana maikaʻi, ʻike ʻole ʻia nā hopena ʻaoʻao i nā kumuhana kanaka. E like me nā pūhui hou, pono e mālama ʻia a nānā ʻia nā hopena ʻino i ka wā e loiloi ai i kona hoʻohana ʻana i ke kanaka.
Ma muli o ke ʻano o ka hana a 7,8-DHF a me nā hopena i nā mea loaʻa TrkB, hiki i kekahi mau hopena ʻaoʻao e pili ana me 7,8-DHF ke komo pū:
ʻO ke poʻo: BDNF a me ka TrkB receptor activation e hoʻoponopono i ka hana neuronal a me ka hauʻoli; ʻO ka hoʻohana ʻana o 7,8-DHF hiki ke hōʻeha i ke poʻo i kekahi poʻe.
Insomnia: ʻO ka hoʻonui ʻia ʻana o ka hana neuronal a me ka synaptic plasticity hiki ke hoʻopilikia i nā ʻano moe, hiki ke alakaʻi i ka insomnia a i ʻole ka pilikia hiamoe.
Nā pilikia o ka ʻōpū: E like me ka nui o nā pūhui bioactive, hiki i ka 7,8-DHF ke hoʻoulu i nā hopena ʻaoʻao o ka ʻōpū, e like me ka nausea, ka luaʻi, a i ʻole ka maʻi maʻi i kekahi poʻe.
He mea nui e hoʻomaopopo he pono e aʻo hou ʻia kēia mau hopena ʻaoʻao i nā hoʻokolohua lapaʻau. Hāʻawi ʻia i kona hiki ke hoʻololi i ka hōʻailona BDNF a me ka hoʻoulu ʻana o ka mea hoʻokipa TrkB, pono e mālama ʻia ke akahele i ka hui ʻana i ka 7,8-DHF me nā lāʻau ʻē aʻe e kuhikuhi ana i kēia mau alahele a i ʻole nā hana like o ka hana.
Ma ke ʻano he pūhui koʻikoʻi, 7,8-Dihydroxyflavone ua hoʻokipa nui ʻia ma muli o kāna mau hana kūlohelohe kūʻokoʻa. No nā mea noiʻi ʻepekema a me nā ʻoihana, he mea koʻikoʻi ka loaʻa ʻana o ka 7,8-Dihydroxyflavone Powder kiʻekiʻe. ʻO ka 7,8-Dihydroxyflavone Powder i hāʻawiʻia e Suzhou Myland he helu CAS o 38183-03-8 a me ka maʻemaʻe a hiki i ka 98%. Ua loaʻa ka huahana i ka mana koʻikoʻi o ka maikaʻi a me ka hoʻokō ʻana i nā kūlana honua, e hōʻoia ana i ka pono a me ka palekana o ka huahana. , kūpono no ka noiʻi ʻepekema, ka hoʻomohala ʻana i ka lāʻau lapaʻau, ka hana ʻana i nā huahana mālama olakino a me nā māla ʻē aʻe, hāʻawi iā ʻoe i kahi koho hilinaʻi.
ʻO ka hōʻoia maikaʻi
Ua ʻike mākou e pili pono ana ka maikaʻi o kā mākou huahana i ka noiʻi a me nā hopena noi. No laila, hahai pono ʻo Suzhou Myland i ka GMP (Good Manufacturing Practice) a me nā kūlana hōʻoia ISO i ka wā o ke kaʻina hana e hōʻoia i ka paʻa a me ke kūlike o kēlā me kēia pūʻulu o nā huahana. Eia hou, ke hoʻomau nei kā mākou hui R&D i ka hana ʻenehana a hoʻoikaika mau e hoʻomaikaʻi mau i ka maikaʻi o ka huahana a me ka hana.
Lawelawe mea kūʻai mai
ʻAʻole hāʻawi wale ʻo Suzhou Myland i nā huahana kiʻekiʻe, akā hoʻolohe pū i nā pono o ka mea kūʻai aku. Loaʻa iā mākou kahi hui kākoʻo loea ʻoihana e hiki ke hāʻawi i nā mea kūʻai aku i nā manaʻo hoʻohana huahana a me ke alakaʻi ʻenehana e kōkua i nā mea kūʻai aku e loaʻa nā hopena maikaʻi aʻe ma ka noiʻi a me ka noi. ʻO ka hoʻāʻo liʻiliʻi a i ʻole ka hana nui, hiki iā mākou ke hāʻawi i nā hopena maʻalahi e hoʻokō i nā pono o nā mea kūʻai aku.
Pehea e loaʻa ai ka pauka 7,8-Dihydroxyflavone
Inā ʻoe e ʻimi nei i ka 7,8-Dihydroxyflavone Powder kiʻekiʻe, ʻo Suzhou Myland kāu koho maikaʻi loa. Hiki iā ʻoe ke hoʻokaʻaʻike mai iā mākou ma:
Paena pūnaewele kūhelu: E kipa i ka pūnaewele kūhelu o Suzhou Myland e aʻo hou e pili ana i ka ʻike huahana a me ke kākoʻo ʻenehana.
Kūkākūkā pūnaewele: E kamaʻilio pololei me kā mākou hui lawelawe mea kūʻai aku ma o ka hana kūkākūkā pūnaewele i hāʻawi ʻia e ka pūnaewele e kiʻi i ka ʻike huahana a me nā huaʻōlelo āu e pono ai.
Kelepona kelepona: Kāhea i kā mākou helu kelepona e kamaʻilio me nā limahana kūʻai ʻoihana a loaʻa i ka ʻike kikoʻī huahana a me nā manaʻo kūʻai.
Nīnau leka uila: Hiki iā ʻoe ke nīnau iā mākou no ka ʻike huahana ma o ka leka uila, a e pane koke mākou iā ʻoe.
I ka hopena
Ma ke ʻano he hui koʻikoʻi me ka nui o nā hana olaola, 7,8-Dihydroxyflavone e lilo mālie i mea nui i ka noiʻi ʻepekema a me nā noi ʻoihana. ʻO ka 7,8-Dihydroxyflavone Powder maʻemaʻe kiʻekiʻe i hāʻawiʻia e Suzhou Myland e hāʻawi i ke kākoʻo ikaika no kāu noiʻi a me ka hoʻomohala huahana me kona kūlana maikaʻi a me ka lawelawe hilinaʻi. Manaʻo mākou e hana pū me ʻoe e ʻimi i nā mea hiki ke hoʻohana ʻia o 7,8-Dihydroxyflavone.
Q: He aha ka 7,8-dihydroxyflavone?
ʻO A: 7,8-Dihydroxyflavone he flavonoids kūlohelohe i ʻike ʻia no kāna mau waiwai neuroprotective a ke aʻo ʻia nei no kāna mau hopena i ka hana cognitive a me ka hoʻonui ʻana i ke ʻano.
Nīnau: He aha nā pono kūpono o 7,8-dihydroxyflavone?
A: Hōʻike ka noiʻi e hiki i ka 7,8-dihydroxyflavone ke kōkua i ka hoʻomaikaʻi ʻana i ka hoʻomanaʻo, hoʻemi i ka hopohopo, a pale i nā maʻi neurodegenerative. Hiki i kona mau waiwai antioxidant ke hoʻoikaika i ke olakino holoʻokoʻa ma o ka hakakā ʻana i ke kaumaha oxidative.
Q: He aha ka bioavailability o 7,8-DHF?
A: ʻO ka bioavailability o 7,8-dihydroxyflavone (7,8-DHF) i nā haʻawina holoholona ma kahi o 5% (i nā ʻiole) ma muli o kona hiki ʻole ke hoʻoheheʻe a me ka wikiwiki o ka metabolism. ʻOiai ʻo kona bioavailability haʻahaʻa, hiki i ka 7,8-DHF ke hele i ka pale koko-lolo a pili i ka lolo. Pono e noiʻi hou e hoʻoholo i kona bioavailability i loko o ke kanaka a e ʻimi i nā ala e hoʻomaikaʻi ai.
Q: Pehea ka 7,8-DHF i kou manao?
A: Ma ke ʻano he nootropic, 7,8-dihydroxyflavone (7,8-DHF) he hopena maikaʻi i ka hana cognitive a me ke ʻano. Loaʻa i kēlā me kēia kanaka ka hoʻomanaʻo ʻoi aku ka maikaʻi, ka hoʻonui ʻana i ka noʻonoʻo, a me ka hiki ke aʻo maikaʻi.
Hoʻopau: No ka ʻike maʻamau wale nō kēia ʻatikala a ʻaʻole pono e manaʻo ʻia he ʻōlelo aʻoaʻo olakino. Loaʻa mai kekahi o ka ʻike moʻomanaʻo blog mai ka Pūnaewele a ʻaʻole ʻoihana. ʻO kēia pūnaewele wale nō ke kuleana no ka hoʻokaʻawale ʻana, ka hoʻopili ʻana a me ka hoʻoponopono ʻana i nā ʻatikala. ʻO ke kumu o ka hāʻawi ʻana i nā ʻike hou aʻe ʻaʻole ia he manaʻo ʻae ʻoe i kāna mau manaʻo a hōʻoia paha i ka ʻoiaʻiʻo o kāna ʻike. E nīnau mau i kahi ʻoihana mālama ola ma mua o ka hoʻohana ʻana i nā mea hoʻohui a i ʻole ka hoʻololi ʻana i kāu ʻano mālama ola kino.
Ka manawa hoʻouna: Oct-14-2024
