He aha ka telomerase activator-cycloastraganol i ʻike ʻia i kēia manawa?

I ka makahiki 1985, ua ʻike mua ʻo Greider et al. i ka telomerase, a hiki i kēia enzyme i ʻike hou ʻia ke hoʻohui i nā hana hou DNA i nā wēlau o nā chromosomes e mālama i ka lōʻihi o ka telomere. ʻO Telomerase kahi hui ribonucleoprotein nona ka ʻiʻo catalytic e komo pū ana me TERT a me TERC, ʻo TERT ke kī i ka hoʻoponopono ʻana i ka hana telomerase. Ke hoʻomau nei ka pōkole o ka lōʻihi o Telomere i ka wā e māhelehele ai nā cell. Ke hiki i kahi waiwai koʻikoʻi, hoʻoulu ia i nā hōʻailona hōʻino DNA, e alakaʻi ana i kahi pōʻaiapuni cell pōkole a me kahi moʻo o nā maʻi hāʻule ʻiʻo i hōʻailona ʻia e nā telomeres pōkole.

I ka makahiki 2010, ua hui pū ka hui ʻAmelika ʻo Geron me ke Kulanui ʻEpekema a me ka ʻenehana o Hong Kong ma kahi papahana noiʻi e nānā i nā mea hoʻoulu telomerase. Ua ʻike ʻiacycloastraganolhiki ke hoʻāla i ka hana telomerase a hoʻoulu i ka hoʻonui ʻana o ka telomere. Ua hoʻolaha ikaika kēia ʻike i ka hoʻomohala ʻana o nā mea hoʻoulu telomerase. Holomua noiʻi a me ka hoʻomohala huahana pili o ka waiʻona astragalus. ʻO Cycloastragenol (CAG) i kēia manawa ka mea hoʻoulu telomerase i hōʻike ʻia i waena o nā huahana kūlohelohe. Hiki iā ia ke hakakā pono i ka pōkole telomere a he anti-aging, anti-apoptosis, anti-fibrosis, hoʻoponopono pale, hoʻolaha i ka hoʻonui ʻana o nā cell a me ka ho'ōla ʻana i nā ʻeha, a pēlā aku. Nā hopena pharmacological, no laila he hopena therapeutic hiki i nā maʻi e pili ana i ka hana ʻole o ka telomere.

ʻO Cycloastragenol a me ka ʻelemakule

nā telomere
He mau ʻano kūikawā nā telomere ma nā wēlau o nā chromosomes e pale ana i nā chromosomes a hoʻopōkole me ka hana hou ʻana o nā chromosome a me ka mahele ʻana o nā cell. ʻElemakule pū nā cell i ka wā e hoʻopōkole ai nā telomere.

telomerase
Hiki i ka Telomerase ke synthesize i nā telomeres e hoʻopaʻa i ka lōʻihi a me ke ʻano o nā telomeres, no laila e pale ana i nā chromosomes a hoʻopaneʻe i ka ʻelemakule o ke kelepona.

Anti-kahiko: He mea hoʻoulu telomerase, nona ka hopena anti-kahiko ma ka hoʻonui ʻana i ka telomerase a no laila e hoʻopaneʻe ana i ka pōkole ʻana o nā telomeres.

ʻO nā Telomeres he mau pāpale i loaʻa ma nā wēlau o nā chromosomes cell e pale aku iā lākou mai ka hōʻino ʻia i ka wā o ka mahele ʻana o ke kelepona. Ke hoʻomau nei nā cell i ka māhele ʻana, hoʻomau ka pōkole o nā telomeres, a hiki i kahi kiko koʻikoʻi kahi e ʻelemakule ai a make paha nā cell. Hiki i ka Telomerase ke hoʻolōʻihi i ka lōʻihi o nā telomeres, a e hoʻonui maoli ʻia ke ola o nā cell.

He ʻāpana pono ʻole o ke ola ka ʻelemakule; akā naʻe, ke aʻo nei nā kānaka noiʻi i nā ʻano lāʻau like ʻole e hoʻāʻo e pale i kekahi o nā hopena o ka ʻelemakule, me ke aʻo ʻana i nā senolytics. ʻO nā senolytics nā hui e hoʻopau i nā cell senescent (ʻelemakule) a ua hōʻike ʻia e hōʻemi i nā hopena o ka ʻelemakule. Hōʻike kahi noiʻi hou he hopena anti-aging ko ka cycloastraganol.

ʻO ke aʻo ʻana, mai Kina mai a paʻi ʻia ma ka International Journal of Molecular Sciences, ua kālele ʻia ma nā pūnaewele kanaka senescent a me nā ʻiole me ka senescence i hoʻoulu ʻia e ka radiation. Hoʻemi ʻo Cycloastragenol i nā pūnaewele senescent me ka ʻole o ka hoʻopilikia ʻana i nā pūnaewele non-senescent. Hoʻemi pū ka mālama ʻana iā Cycloastragenol i nā protein i loko o nā pūnaewele senescent e pono ai no ka ulu ʻana o nā pūnaewele a me ke ola. Eia kekahi, kāohi ia i nā neʻe ʻana o nā pūnaewele e pili ana i nā pūnaewele mumū a me nā kaʻina hana e pili ana i ka makahiki. Ua ʻike ʻia nā ʻiole ʻelemakule i mālama ʻia me ka cycloastraganol he emi iho nā pūnaewele senescent a hoʻomaikaʻi i ka hana kino e pili ana i ka makahiki.

Hoʻemi ʻo Cycloastragenol i nā pūnaewele senescent

ʻO ka senescence kahi hōʻailona kaulana o ka ʻelemakule, akā ua ʻike nā kānaka noiʻi e hiki i ka hoʻopau ʻana i nā cell senescent a me kā lākou mau molekala hōʻailona pro-inflammatory ke kōkua i ka pale ʻana i nā maʻi e pili ana i ka makahiki a hoʻohuli iā lākou i kekahi mau hihia. Maanei, ua mālama nā kānaka noiʻi i nā cell kanaka me ka cycloastraganol a ua ʻike ʻia ua hoʻopau pono ia i nā cell senescent me ka ʻole o ka hoʻopilikia ʻana i nā cell non-senescent. Eia kekahi, ua hoʻemi nui ʻia nā māka cellular o nā cell senescent ma hope o ka mālama ʻana i ka cycloastraganol.

Ua hōʻike ʻia ma mua nā noiʻi ʻana ua pili ke ala PI3K/AKT/mTOR—he ala hōʻailona e pili ana i ka ulu ʻana o ke kelepona a me ke ola ʻana—i nā kaʻina hana mumū i hoʻomaka ʻia e nā kelepona senescent, e kōkua ana i ka hoʻolaha ʻana i ka senescence i nā kelepona a puni. Ua ʻike nā mea noiʻi ua kōkua ka cycloastragenol i ka hōʻemi ʻana i nā protein ma kēia ala, e hōʻike ana e hana paha ka hui ma ke ālai ʻana i ke ala PI3K/AKT/mTOR e kōkua i ka pale ʻana i ka ʻelemakule. Eia kekahi, ua hōʻike ʻia ka cycloastragenol e hōʻemi i ka hiki o nā kelepona senescent ke hoʻolaha i ka senescence ma o ka hoʻokuʻu ʻana o nā molekala mumū, nā mea ulu, a me nā immunomodulators, e kūlike me nā manaʻo e hiki i ka hōʻemi ʻana i ka hōʻailona PI3K, AKT, a me mTOR ke hōʻemi i nā hopena hoʻolaha senescence ma waena o nā kelepona a puni.

No nā saponins triterpene ʻo Cycloastragenol a loaʻa nui ia mai ka hydrolysis o astragaloside IV. He kaumaha molekala liʻiliʻi kona a me ka lipophilicity ikaika, he mea maikaʻi ia no ka komo ʻana o ka biofilm a me ka omo ʻana o ka gastrointestinal e hoʻokō ai i ka bioavailability maikaʻi aʻe. ʻO ka pono o ka cycloastragalinol
1. Ka mālama ʻana i ka hōʻino ʻana o ka lolo
2. Hoʻomaikaʻi i ka fibrosis akepaʻa
3. Ka mālama ʻana i ka osteoporosis
4. Ka hopena anti-kahiko
5. Hoʻopaneʻe i ka ʻelemakule ʻana o nā pūnaewele

No ke aha he mea pono e hana i ka cycloastraganol?

① Loaʻa iā Cycloastraganol nā hopena pharmacological like ʻole e like me ke kāohi ʻana i ka apoptosis cell lolo a me ka neuroinflammation i ka wā o ka ischemia cerebral a me ka mālama ʻana i ka pale koko-lolo.
② ʻO Cycloastragenol wale nō ka hui terpenoid molekole liʻiliʻi me ka hana telomerase i ʻike ʻia a hiki i kēia manawa a hiki ke mālama i nā maʻi neurodegenerative.
③ Loaʻa iā ia nā hopena o ke kāohi ʻana i ka fibrosis myocardial a me ka hoʻoikaika ʻana i ka pale ʻana i ka maʻi ʻaʻai. He molekole kaulana ia i ka noiʻi a me ka hoʻomohala ʻana i nā lāʻau anti-kahiko.

Nā pilikia e kū nei

He haʻahaʻa loa ka nui o ka cycloastraganol ma Astragalus membranaceus a he paʻakikī ke loaʻa pololei. ʻO ke ʻano hana hana cycloastraganol e kū nei e hilinaʻi nei i ka unuhi ʻana o ka lāʻau lapaʻau Kina kuʻuna, kahi i loaʻa nui ʻia ma ka hoʻololi ʻana i ka astragaloside IV ma Astragalus membranaceus. ʻO ia hoʻi, loaʻa ka astragaloside IV ma o ke kanu ʻana i ka astragalus a me ka ʻenehana moʻomeheu kiko, a laila hoʻololi ʻia ka astragaloside IV i cycloastragaloside me ka hoʻohana ʻana i ka acidolysis, Smith degradation, enzyme a me ka microbial hydrolysis. Eia nō naʻe, he pipiʻi kēia mau ʻano hoʻomākaukau, maʻalahi ke hoʻohaumia i ke kaiapuni, paʻakikī ke hoʻokaʻawale a hoʻomaʻemaʻe, a ʻaʻole kūpono i ka hoʻopili ʻana a me ka hoʻolaha ʻana. No laila, ua hoʻohuli ka poʻe i ko lākou manaʻo i ka synthesis artificial o cycloastraganol.

Pehea e hoʻohana ai i ka biology synthetic e synthesize? ---Synthetic Biology

ʻO ke Synthetic Biology e pili ana i ka hoʻolālā i kuhikuhi ʻia, ka hoʻololi ʻana, a me ka hoʻokumu ʻana i ke "ola hana" me nā hana kūlohelohe ʻole ma lalo o ke alakaʻi ʻana o nā manaʻo ʻenekinia, ʻo ia hoʻi, ka ʻenekinia o ka biology. Ma ke ʻano laulā, ua hana ʻia me ka hoʻohana ʻana i nā ʻano hana olaola.