ʻO Taurine kahi micronutrient pono a nui ka aminosulfonic acid. Hoʻolaha nui ʻia i nā ʻiʻo like ʻole a me nā ʻāpana o ke kino. Loaʻa ia ma kahi kūlana manuahi i ka wai interstitial a me ka wai intracellular. No ka mea, ua noho mua ia ma ka inoa ma hope o ka loaʻa ʻana i loko o ka bile bipi. Hoʻohui ʻia ka Taurine i nā mea inu hana maʻamau e hoʻopiha i ka ikehu a hoʻomaikaʻi i ka luhi.
I ka makahiki 1985, Greider et al. Ua ʻike mua ʻia ka telomerase, a hiki i kēia enzyme i ʻike hou ʻia ke hoʻohui hou i ka DNA i nā wēlau o nā chromosomes e mālama i ka lōʻihi telomere. ʻO Telomerase kahi ribonucleoprotein complex nona ka catalytic core e komo pū ana me TERT a me TERC, nona ka TERT ke kī i ka hoʻoponopono ʻana i ka hana telomerase. Ke hoʻopōkole nei ka lōʻihi o Telomere i ka wā e māhele ai nā pūnaewele. Ke hōʻea ʻo ia i kahi waiwai koʻikoʻi, hoʻoulu ia i nā hōʻailona hōʻino DNA, e alakaʻi ana i kahi pōʻaiapili kelepona pōkole a me kahi ʻano o nā maʻi hōʻino ʻole i hōʻike ʻia e nā telomeres pōkole.
Ma 2010, ua hui pū ka hui ʻAmelika ʻo Geron me ke Kulanui o ʻEpekema a me ʻenehana ʻo Hong Kong ma kahi papahana noiʻi e nānā i nā mea hana telomerase. Ua ʻike ʻia kēlācycloastraganolhiki ke ho'āla i ka hana telomerase a hoʻoulu i ka hoʻonui telomere. Hoʻoikaika ikaika kēia ʻike i ka hoʻomohala ʻana o nā mea hoʻoulu telomerase. Ka holomua noiʻi a me ka hoʻomohala ʻana i nā huahana pili i ka waiʻona astragalus. ʻO Cycloastragenol (CAG) wale nō ka mea i hōʻike ʻia i ka telomerase activator ma waena o nā huahana kūlohelohe. Hiki iā ia ke hakakā maikaʻi i ka pōkole telomere a loaʻa iā ia ka anti-aging, anti-apoptosis, anti-fibrosis, immune regulation, paipai i ka hoʻonui ʻana o ka cell a me ka ho'ōla ʻeha, etc. Nā hopena Pharmacological, a laila e loaʻa ai nā hopena therapeutic i nā maʻi pili i ka telomere dysfunction.
Cycloastragenol a me ka ʻelemakule
nā telomere
ʻO nā Telomeres nā hale kūikawā ma nā wēlau o nā chromosomes e pale i nā chromosomes a pōkole me ka replication chromosome a me ka mahele cell. ʻO nā pūnaewele pū kekahi me ka pōkole o nā telomeres.
telomerase
Hiki i ka Telomerase ke hoʻohui i nā telomeres e hoʻopaʻa i ka lōʻihi a me ke ʻano o nā telomeres, ma laila e pale ai i nā chromosomes a hoʻopaneʻe i ka ʻelemakule.
Anti-aging: He telomerase activator, e pāʻani ana i ka hopena anti-aging ma o ka hoʻonui ʻana i ka telomerase a ma laila e lohi ai i ka pōkole o nā telomeres.
ʻO nā Telomeres nā pāpale i loaʻa ma nā wēlau o nā chromosomes cell e pale ai iā lākou mai ka pōʻino i ka wā o ka māhele cell. Ke hoʻomau nei ka māhele ʻana o nā pūnaewele, hoʻopōkole ʻia nā telomeres, a hiki i kahi koʻikoʻi kahi e ʻelemakule ai a make paha nā cell. Hiki i ka Telomerase ke hoʻolōʻihi i ka lōʻihi o nā telomeres, a e hoʻonui maoli ke ola o nā cell e like me ia.
ʻO ka ʻelemakule kahi ʻāpana hiki ʻole ke ola; akā naʻe, ke aʻo nei nā mea noiʻi i nā ʻano lapaʻau like ʻole e hoʻāʻo e pale i kekahi o nā hopena o ka ʻelemakule, me ke aʻo ʻana i ka senolytics. ʻO nā Senolytics nā pūhui e hoʻopau i nā cell senescent (ʻelemakule) a ua hōʻike ʻia e hōʻemi i nā hopena o ka ʻelemakule. Ua hōʻike ʻia kahi noiʻi hou he hopena anti-aging ka cycloastraganol.
ʻO ke aʻo ʻana, mai Kina a i paʻi ʻia ma ka International Journal of Molecular Sciences, ua kālele ʻia i nā cell senescent kanaka a me nā ʻiole me ka radiation-induced senescence. Hoʻemi ʻo Cycloastragenol i nā cell senescent me ka ʻole o ka hoʻopili ʻana i nā cell non-senescent. ʻO ka hoʻomaʻamaʻa ʻana ʻo Cycloastragenol e hoʻemi i nā protein i loko o nā cell senescent e pono ai no ka ulu ʻana a me ke ola. Hoʻohui ia, kaohi ia i ka neʻe ʻana o nā cell e pili ana i nā ʻili a me nā kaʻina hana e pili ana i ka makahiki. Ua ʻike ʻia ka liʻiliʻi o nā ʻiole kahiko i mālama ʻia me ka cycloastraganol a ʻoi aku ka maikaʻi o ka hana kino pili i ka makahiki.
Hoʻemi ʻo Cycloastragenol i nā cell senescent
ʻO ka Senescence kahi hiʻohiʻona kaulana o ka ʻelemakule, akā ua ʻike nā mea noiʻi ʻo ka hoʻopau ʻana i nā cell senescent a me kā lākou molekele hōʻailona pro-inflammatory hiki ke kōkua i ka pale ʻana i nā maʻi pili makahiki a hoʻohuli iā lākou i kekahi mau hihia. Maʻaneʻi, ua mālama nā mea noiʻi i nā pūnaewele kanaka me ka cycloastraganol a ua ʻike ua hoʻopau maikaʻi ia i nā cell senescent me ka ʻole o ka hoʻopili ʻana i nā cell non-senescent. Eia kekahi, ua hoʻemi nui ʻia nā māka kelepona o nā senescent cell ma hope o ka mālama ʻana i ka cycloastraganol.
Ua hōʻike ka noiʻi mua i ke ala PI3K / AKT / mTOR-he ala hōʻailona e pili ana i ka ulu ʻana o ka cell a me ke ola ʻana-i loko o nā kaʻina inflammatory i hoʻomaka ʻia e nā cell senescent, e kōkua ana i ka hoʻoikaika ʻana i ka senescence i loko o nā cell a puni. Ua ʻike nā mea noiʻi ua kōkua ka cycloastragenol i ka hōʻemi ʻana i nā protein i kēia ala, e hōʻike ana e hana paha ka pūhui ma ke kāohi ʻana i ke ala PI3K/AKT/mTOR e kōkua i ka pale ʻana i ka ʻelemakule. Eia kekahi, ua hōʻike ʻia ka cycloastragenol e hōʻemi i ka hiki o nā cell senescent e hoʻoikaika i ka ʻōpio ma o ka hoʻokuʻu ʻana i nā molekele inflammatory, nā mea ulu, a me nā immunomodulators, e kūlike me nā manaʻo e hōʻemi ana i ka hōʻailona PI3K, AKT, a me ka mTOR hiki ke hōʻemi i nā hopena hoʻonui i ka senescence ma waena o nā cell a puni. .
Aia ka Cycloastragenol i ka triterpene saponins a loaʻa nui mai ka hydrolysis o astragaloside IV. He liʻiliʻi liʻiliʻi ke kaumaha a me ka lipophilicity ikaika, he mea pono ia i ka biofilm penetration a me ka absorption gastrointestinal e hoʻokō i ka bioavailability maikaʻi. ʻO ka maikaʻi o ka cycloastragalinol
1. Ka mālama ʻana i ka pōʻino o ka lolo
2. Hoʻonui i ka fibrosis ate
3. Lapaʻau ʻana i ka osteoporosis
4. Ka hopena anti-kahiko
5. Hoʻopaneʻe i ka ʻelemakule cell
No ke aha e pono ai ke synthesize i ka cycloastraganol?
① Loaʻa i ka Cycloastraganol nā hopena pharmacological like ʻole e like me ke kāohi ʻana i ka lolo apoptosis a me ka neuroinflammation i ka wā cerebral ischemia a me ka mālama ʻana i ka pale koko-lolo.
② ʻO Cycloastragenol ka mea liʻiliʻi liʻiliʻi terpenoid pūhui me ka hana telomerase i ʻike ʻia i kēia manawa a hiki ke mālama i nā maʻi neurodegenerative.
③ Loaʻa iā ia nā hopena o ka pale ʻana i ka myocardial fibrosis a me ka hoʻonui ʻana i ka pale anti-tumor. He mole kaulana ia i ka noiʻi a me ka hoʻomohala ʻana i nā lāʻau anti-aging.
Nā pilikia e kū nei
He haʻahaʻa loa ka ʻike o ka cycloastraganol ma Astragalus membranaceus a paʻakikī ke loaʻa pololei. ʻO ka hoʻolālā hana cycloastraganol e kū nei e hilinaʻi nei i ka unuhi ʻana o ka lāʻau lapaʻau Kina, ka mea i loaʻa ma ka hoʻololi ʻana i ka astragaloside IV i Astragalus membranaceus. ʻO ia hoʻi, loaʻa ka astragaloside IV ma o ka kanu ʻana astragalus a me ka ʻenehana moʻomeheu kiko, a laila hoʻololi ʻia ka astragaloside IV i cycloastragaloside me ka hoʻohana ʻana i ka acidolysis, Smith degradation, enzyme a me microbial hydrolysis. Eia nō naʻe, he kumu kūʻai kēia mau ʻano hoʻomākaukau, maʻalahi e hoʻohaumia i ke kaiapuni, paʻakikī e hoʻokaʻawale a hoʻomaʻemaʻe, ʻaʻole kūpono i ka noi a me ka hoʻolaha ʻana. No laila, ua huli ka poʻe i ko lākou manaʻo i ka synthesis artificial o cycloastraganol.
Pehea e hoʻohana ai i ka biology synthetic e synthesize? ---Synthesis Biology
ʻO ka Synthetic Biology e pili ana i ka hoʻolālā i manaʻo ʻia, ka hoʻololi ʻana, a me ka hana ʻana i "ola kūlohelohe" me nā hana kūlohelohe ma lalo o ke alakaʻi ʻana o nā manaʻo ʻenekinia, ʻo ia hoʻi, ka ʻenekinia o ka biology. Ma ka ʻōlelo maʻamau, hana ʻia me ka hoʻohana ʻana i nā ʻano biological.
Hoʻopau: No ka ʻike maʻamau wale nō kēia ʻatikala a ʻaʻole pono e manaʻo ʻia he ʻōlelo aʻoaʻo olakino. Loaʻa mai kekahi o ka ʻike moʻomanaʻo blog mai ka Pūnaewele a ʻaʻole ʻoihana. ʻO kēia pūnaewele wale nō ke kuleana no ka hoʻokaʻawale ʻana, ka hoʻopili ʻana a me ka hoʻoponopono ʻana i nā ʻatikala. ʻO ke kumu o ka hāʻawi ʻana i nā ʻike hou aʻe ʻaʻole ia he manaʻo ʻae ʻoe i kāna mau manaʻo a hōʻoia paha i ka ʻoiaʻiʻo o kāna ʻike. E nīnau mau i kahi ʻoihana mālama ola ma mua o ka hoʻohana ʻana i nā mea hoʻohui a i ʻole ka hoʻololi ʻana i kāu ʻano mālama ola kino.
Ka manawa hoʻouna: ʻAukake-13-2024
