He aha ka spermidine? He alakaʻi maʻalahi i ka spermidine

ʻO ka SpermidineHe ʻano polyamine. He ʻano biomolecules liʻiliʻi, momona, polycationic (-NH3+) nā polyamines. ʻEhā mau polyamines nui i loko o nā mammals: spermine, spermidine, putrescine a me cadaverine. No nā tetramines ka spermine, no nā triamines ka spermidine, no nā diamines ka putrescine a me cadaverine. Hāʻawi nā helu like ʻole o nā hui amino iā lākou i nā ʻano physiological like ʻole.

ʻO ka Spermidine i loko o ke kanaka

ʻAʻole wale nō ka Spermidine i loko o ka semen, akā ua hoʻolaha nui ʻia hoʻi i nā ʻiʻo a me nā hunaola ʻē aʻe o ke kino kanaka. ʻO ka nui o ka spermidine intracellular e hilinaʻi nui ʻia i ʻehā mau kumu:

①Hana ʻana i loko o ke kelepona:

ʻO Arginine → putrescine → spermidine ← spermine. ʻO Arginine ka mea maka nui no ka hana ʻana o ka spermidine i loko o nā cell. Hoʻoulu ʻia e arginase e hana i ka ornithine a me ka urea. A laila hoʻohana ʻia ʻo Ornithine e hana i ka putrescine ma lalo o ka hana a ornithine decarboxylase (ODC1). ʻO kēia ke kaʻina hana e kaupalena ana i ka wikiwiki), hana ka putrescine i ka spermidine ma lalo o ka hana a spermidine synthase (SPDS). Hiki ke hana ʻia ʻo Spermidine e ka hoʻohaʻahaʻa ʻana o ka spermine.

②Ka lawe ʻana ma waho o ke kelepona:

Ua māhele ʻia i ka ʻai ʻana i ka meaʻai a me ka hana ʻana o nā microbial intestinal. ʻO nā meaʻai waiwai i ka spermidine e komo pū me ka germ palaoa, natto, soybeans, halo, a me nā mea ʻē aʻe. ʻO ka spermine a me ka spermidine i ʻai ʻia mai ka meaʻai ua omo koke ʻia mai nā ʻōpū a hoʻolaha ʻia me ka ʻole o ka hōʻino ʻia, no laila ʻokoʻa loa ka nui o ka spermidine i loko o ke koko. Hiki i nā bacteria probiotic i loko o ka microbiota intestinal e like me Bifidobacterium ke hana pū i ka spermidine.

③Katabolism:

Hoʻoheheʻe mālie ʻia ka spermine i loko o ke kino i loko o ka spermidine a me ka putrescine e N1-acetyltransferase (SSAT), polyamine oxidase (PAO) a me nā amine oxidases ʻē aʻe, ʻoiai ua hoʻololi hou ʻia ka putrescine i ka waikawa aminobutyric e nā oxidases. ʻO ka hope loa, hoʻopuka ʻia nā ion amine a me ke kalapona ʻokikene a hoʻokuʻu ʻia mai ke kino.

④Makahiki:

Hoʻololi ka nui o ka spermidine me ka makahiki. Ua ana nā kānaka noiʻi i ka nui o nā polyamines i loko o nā ʻiʻo like ʻole a me nā ʻōpū o nā ʻiole 3-pule, 10-pule a me 26-pule a ua ʻike ʻia ua mālama nui ʻia ia ma ka pancreas, ka lolo a me ka uterus. E emi iki ana nā loli i loko o ka ʻōpū me ka makahiki, a e emi nui ana i loko o ka thymus, spleen, ovary, ate, ʻōpū, māmā, puʻupaʻa, puʻuwai a me nā ʻiʻo. ʻAʻole paʻakikī iā mākou ke kuhi he mau kumu no kēia loli e pili ana i nā loli ʻai, nā loli i ke ʻano o ka flora ʻōpū, ka emi ʻana o ka hana o ka polyamine synthase, a pēlā aku.

Pahuhopu kūlohelohe o ka spermidine

No ke aha he mea nui ia ʻano mole liʻiliʻi maʻalahi no ke kino o ke kanaka? Aia ka mea huna i kona ʻano: ʻO Spermidine kahi mole liʻiliʻi polycationic (-NH3+) momona amine e kū nei i loko o kahi ʻano multi-protonated ma lalo o nā kūlana pH physiological, me nā ions maikaʻi i hoʻolaha ʻia ma loko o ke kaulahao kalapona. ʻO ka hoʻouka uila, he hana physiological ikaika.

No laila, inā he mau nucleic acids, phospholipids, acidic proteins i loaʻa nā acidic residues, pectic polysaccharides i loaʻa nā carboxyl groups a me sulfates, a i ʻole neurotransmitters a me hormones (dopamine, epinephrine, serotonin, thyroid hormone, etc.) me nā ʻano like, he pahuhopu paha ia no ka spermidine binding. ʻO nā mea koʻikoʻi loa:

① ʻAkika nukleika:

Ua ʻike ʻia nā haʻawina e loaʻa ana ka hapa nui o nā polyamines ma ke ʻano o nā hui polyamine-RNA i loko o nā cell, me 1-4 mau like o ka polyamine i hoʻopaʻa ʻia no 100 mau like o nā hui phosphate. No laila, ʻo ke kuleana nui o ka spermidine e pili ana i nā loli kūkulu a me ka unuhi ʻana o RNA, e like me ka hoʻopilikia ʻana i nā pae like ʻole o ka synthesis protein ma o ka hoʻopilikia ʻana i ke kūkulu lua o ka mRNA, tRNA a me rRNA. Hiki i ka Spermidine ke hana i nā "alahaka" paʻa ma waena o nā kaula DNA helical pālua, e hōʻemi ana i ka hiki ʻana o nā radical free a i ʻole nā ​​​​mea hōʻino DNA ʻē aʻe, a me ka pale ʻana i ka DNA mai ka denaturation thermal a me ka radiation X-ray.

②Pūmua:

Hiki i ka Spermidine ke hoʻopaʻa i nā protein e lawe ana i nā uku maikaʻi ʻole nui a hoʻololi i ke ʻano spatial o ka protein, no laila e hoʻopilikia ai i kāna hana physiological. ʻO nā hiʻohiʻona e pili ana i nā protein kinases/phosphatases (kahi loulou koʻikoʻi i nā ala transduction hōʻailona he nui), nā enzymes i komo i ka histone methylation a me ka acetylation (e hoʻopilikia ana i ka hōʻike ʻana o ka gene ma ka hoʻololi ʻana i ka epigenetics), acetylcholinesterase (kahi ʻāpana koʻikoʻi o nā maʻi neurodegenerative), kekahi o nā lāʻau lapaʻau), nā mea loaʻa ion channel (e like me AMPA, nā mea loaʻa AMDA), a pēlā aku.

He mea hana i hoʻopaʻa inoa ʻia ʻo Suzhou Myland e hāʻawi ana i ka pauka Spermidine kiʻekiʻe a me ka maʻemaʻe kiʻekiʻe.

Ma Suzhou Myland, ua kūpaʻa mākou i ka hāʻawi ʻana i nā huahana maikaʻi loa ma nā kumukūʻai maikaʻi loa. Ua hoʻāʻo pono ʻia kā mākou pauka Spermidine no ka maʻemaʻe a me ka ikaika, e hōʻoiaʻiʻo ana e loaʻa iā ʻoe kahi mea hoʻohui kiʻekiʻe hiki iā ʻoe ke hilinaʻi. Inā makemake ʻoe e kākoʻo i ke olakino cellular, hoʻoikaika i kāu ʻōnaehana pale a hoʻomaikaʻi paha i ke olakino holoʻokoʻa, ʻo kā mākou pauka Spermidine ke koho kūpono loa.

Me 30 mau makahiki o ka ʻike a hoʻokele ʻia e ka ʻenehana kiʻekiʻe a me kahi hoʻolālā R&D i hoʻonohonoho pono ʻia, ua hoʻomohala ʻo Spermidine i nā huahana hoʻokūkū e lilo i ʻoihana hoʻohui ʻepekema ola hou, synthesis maʻamau a me nā lawelawe hana.

Eia kekahi, he mea hana i hoʻopaʻa inoa ʻia ʻo Suzhou Myland i ka FDA. He hou a he multifunctional nā kumuwaiwai R&D o ka hui, nā hale hana, a me nā mea hana loiloi, a hiki ke hana i nā kemika mai milligrams a i tons ma ke anakahi, a kūlike me nā kūlana ISO 9001 a me nā kikoʻī hana GMP.