He aha ka spermidine? He alakaʻi maʻalahi i ka spermidine

Spermidinehe ʻano polyamine. ʻO nā polyamines nā mea liʻiliʻi, momona, polycationic (-NH3+) biomolecules. ʻEhā mau polyamines nui i nā mammals: spermine, spermidine, putrescine a me cadaverine. No nā tetramines ka Spermine, no nā triamines ka spermidine, no nā diamines ka putrescine a me ka cadaverine. Hāʻawi nā helu like ʻole o nā pūʻulu amino iā lākou i nā waiwai physiological like ʻole.

Spermidine i loko o ke kanaka

ʻAʻole ʻo Spermidine wale nō i loko o ka semen, akā ua hoʻolaha nui ʻia i loko o nā ʻiʻo a me nā cell o ke kino kanaka. ʻO ka helu ʻana o ka spermidine intracellular e hilinaʻi nui ʻia ma nā kumu ʻehā:

①Intracellular synthesis:

Arginine → putrescine → spermidine ← spermine. ʻO Arginine ka mea nui no ka synthesis o spermidine i loko o nā pūnaewele. Hoʻopili ʻia ia e ka arginase e hana i ka ornithine a me ka urea. Hoʻohana ʻia ʻo Ornithine e hana i ka putrescine ma lalo o ka hana a ornithine decarboxylase (ODC1). ʻO kēia ke kaʻina palena palena), hoʻopuka ka putrescine i ka spermidine ma lalo o ka hana a spermidine synthase (SPDS). Hiki ke hana ʻia ka spermidine e ka hoʻohaʻahaʻa ʻana o ka spermine.

②Ka lawe ʻana i ke kelepona:

Māhele ʻia i ka ʻai meaʻai a me ka synthesis microbial intestinal. ʻO nā meaʻai momona i ka spermidine ka hua palaoa, natto, soybeans, mushrooms, etc. ʻO ka spermidine a me ka spermidine i hoʻomoʻa ʻia mai ka meaʻai e hoʻopaʻa koke ʻia mai ka ʻōpū a hāʻawi ʻia me ka hoʻohaʻahaʻa ʻole ʻana, no laila ke ʻano o ka spermidine i loko o ke koko he ʻano like ʻole. Hiki i ka bacteria probiotic i loko o ka microbiota intestinal e like me Bifidobacterium ke hana pū i ka spermidine.

③Cabolism:

Hoʻopau mālie ʻia ka sperm i loko o ke kino i spermidine a me putrescine e N1-acetyltransferase (SSAT), polyamine oxidase (PAO) a me nā amine oxidases ʻē aʻe, ʻoiai ʻo putrescine e hoʻololi hou ʻia i aminobutyric acid e nā oxidases. ʻO ka hope, hoʻopuka ʻia nā ion amine a me carbon dioxide mai ke kino.

④Makahiki:

Hoʻololi ke ʻano o ka spermidine me ka makahiki. Ua ana nā kānaka noiʻi i ka ʻike ʻana o nā polyamines i loko o nā ʻiʻo like ʻole a me nā ʻāpana o nā ʻiole 3-week-old, 10-week-old a me 26-week-old a ʻike ʻia ua mālama ʻia i loko o ka pancreas, lolo a me ka ʻōpū. ʻO nā hoʻololi i loko o ka ʻōpū e emi iki me ka makahiki, a emi nui i ka thymus, spleen, ovary, ate, ʻōpū, akemāmā, puʻupaʻa, puʻuwai a me ka ʻiʻo. ʻAʻole paʻakikī iā mākou ke noʻonoʻo e pili ana nā kumu o kēia hoʻololi i ka hoʻololi ʻana i ka meaʻai, hoʻololi i ka hoʻolālā flora intestinal, hoʻemi i ka hana o ka polyamine synthase, etc.

Pahu maoli o spermidine

No ke aha he mea koʻikoʻi ko ke kino o ke kanaka kahi mole liʻiliʻi liʻiliʻi? Aia ka mea huna i kona ʻano: ʻO Spermidine he polycationic (-NH3+) fatty amine mole liʻiliʻi i loaʻa i kahi ʻano multi-protonated ma lalo o nā kūlana pH physiological, me nā ion maikaʻi i puʻunaue ʻia ma ke kaula kalapona. ʻO ka uku uila, he hana physiological ikaika.

No laila, inā he nucleic acids, phospholipids, acidic proteins i loaʻa nā koena acidic, pectic polysaccharides i loaʻa nā pūʻulu carboxyl a me nā sulfates, a i ʻole nā ​​neurotransmitters a me nā hormones (dopamine, epinephrine, serotonin, thyroid hormone, etc.) me nā hale like. paa. ʻO nā mea koʻikoʻi loa:

① Nucleic acid:

Ua ʻike nā haʻawina ʻo ka hapa nui o nā polyamines ma ke ʻano o nā polyamine-RNA complexes i loko o nā pūnaewele, me 1-4 mau mea like o ka polyamine i hoʻopaʻa ʻia i kēlā me kēia 100 like o nā pūhui phosphate. No laila, pili ka hana nui o ka spermidine i nā hoʻololi a me ka unuhi ʻana o RNA, e like me ka hoʻopili ʻana i nā pae like ʻole o ka synthesis protein ma o ka hoʻopili ʻana i ke ʻano lua o ka mRNA, tRNA a me rRNA. Hiki i ka Spermidine ke hana i nā "alahaka" paʻa ma waena o nā kaula DNA helika ʻelua, e hōʻemi ana i ka hiki ʻana o nā radical manuahi a i ʻole nā ​​​​mea hana ʻino DNA ʻē aʻe, a me ka pale ʻana i ka DNA mai ka denaturation thermal a me ka radiation X-ray.

②Pikikini:

Hiki i ka Spermidine ke hoʻopaʻa i nā protein e lawe ana i nā koina maikaʻi ʻole a hoʻololi i ka conformation spatial o ka protein, a laila e hoʻopilikia i kāna hana physiological. ʻO nā laʻana he protein kinases/phosphatases (he loulou koʻikoʻi i nā ala transduction hōʻailona he nui), nā enzyme i komo i ka histone methylation a me ka acetylation (e pili ana i ka hōʻike gene ma ka hoʻololi ʻana i ka epigenetics), acetylcholinesterase (kahi mea nui o nā maʻi neurodegenerative). ʻO kekahi o nā lāʻau lapaʻau lapaʻau), nā mea hoʻokipa ion channel (e like me AMPA, AMDA receptors), etc.

ʻO Suzhou Myland kahi mea hana inoa FDA e hāʻawi ana i ka pauka Spermidine kiʻekiʻe a me ka maʻemaʻe kiʻekiʻe.

Ma Suzhou Myland, ua kūpaʻa mākou i ka hāʻawi ʻana i nā huahana maikaʻi loa i nā kumukūʻai maikaʻi loa. ʻO kā mākou Spermidine pauka i ho'āʻo ikaikaʻia no ka maʻemaʻe a me ka ikaika, e hōʻoiaʻiʻo ana e loaʻa iāʻoe kahi mea hoʻopihapiha kiʻekiʻe āu e hilinaʻi ai. Inā makemake ʻoe e kākoʻo i ke olakino cellular, hoʻonui i kāu ʻōnaehana pale a hoʻomaikaʻi i ke olakino holoʻokoʻa, ʻo kā mākou Spermidine pauka ke koho maikaʻi loa.

Me 30 mau makahiki o ka ʻike a alakaʻi ʻia e ka ʻenehana kiʻekiʻe a me kahi hoʻolālā R&D i hoʻopaʻa ʻia, ua hoʻomohala ʻo Spermidine i kahi ʻano o nā huahana hoʻokūkū e lilo i mea hoʻohui ʻepekema ola hou, synthesis maʻamau a me nā hui lawelawe hana.

Eia kekahi, ʻo Suzhou Myland kekahi mea hana inoa FDA. ʻO nā kumuwaiwai R&D o ka hui, nā lako hana, a me nā mea hana analytical he mea hou a multifunctional, a hiki iā ia ke hana i nā kemika mai ka milligrams a hiki i nā tona i ka pālākiō, a hoʻokō i nā kūlana ISO 9001 a me nā kikoʻī hana GMP.