Ua ʻike nā kānaka ʻepekema i ko kākou ʻelemakule ʻana, e emi mālie ana ko kākou mitochondria a hoʻopuka i ka ikehu liʻiliʻi. Hiki i kēia ke alakaʻi i nā maʻi e pili ana i ka ʻelemakule e like me nā maʻi neurodegenerative, nā maʻi puʻuwai, a me nā mea hou aku.
ʻUrolithin A
He metabolite kūlohelohe ʻo Urolithin A me nā hopena antioxidant a me antiproliferative. Ua ʻike nā mea loea meaʻai mai ke Kulanui ʻo Nova Southeastern ma ʻAmelika Hui Pū ʻIa e hiki i ka hoʻohana ʻana i ka urolithin A ma ke ʻano he mea hana i ka ʻai ke hoʻopaneʻe i ke kaʻina hana ʻelemakule a pale i ka ulu ʻana o nā maʻi e pili ana i ka ʻelemakule.
Hoʻopuka ʻia ʻo Urolithin A (UA) e ko mākou bacteria ʻōpū ma hope o ka ʻai ʻana i nā polyphenols i loaʻa i nā meaʻai e like me nā pomegerane, nā ʻōpena, a me nā walnuts. Hoʻoulu ka hoʻopihapiha UA i nā ʻiole waena i nā sirtuins a hoʻonui i ka NAD+ a me nā pae ikehu cellular. ʻO ka mea nui, ua hōʻike ʻia ʻo UA e hoʻomaʻemaʻe i nā mitochondria i hōʻino ʻia mai nā ʻiʻo kanaka, no laila e hoʻomaikaʻi ana i ka ikaika, ke kū'ē ʻana i ka luhi, a me ka hana haʻuki. No laila, hiki i ka hoʻopihapiha UA ke hoʻolōʻihi i ke ola ma ke kū'ē ʻana i ka ʻelemakule ʻiʻo.
ʻAʻole i loaʻa pololei ʻo Urolithin A mai ka meaʻai, akā ʻo nā hui e like me ka ellagic acid a me nā ellagitannins i loko o nā nati, nā pomegerane, nā hua waina a me nā hua ʻē aʻe e hana i ka urolithin A ma hope o ka hoʻopili ʻia ʻana e nā microorganisms ʻōpū.
ʻO ka Spermidine
He ʻano kūlohelohe ʻo Spermidine o kahi polyamine i loaʻa ka nānā ʻia i nā makahiki i hala iho nei no kona hiki ke hoʻolōʻihi i ke ola a hoʻonui i ka lōʻihi o ke olakino. E like me NAD+ a me CoQ10, he mole kūlohelohe ka spermidine e emi ana me ka makahiki. E like me UA, hana ʻia ka spermidine e ko mākou bacteria ʻōpū a hoʻoulu i ka mitophagy - ka wehe ʻana i nā mitochondria maikaʻi ʻole a hōʻino ʻia. Hōʻike nā haʻawina ʻiole e hiki i ka hoʻohui ʻana o ka spermidine ke pale aku i ka maʻi puʻuwai a me ka ʻelemakule hānau wahine. Eia kekahi, ua hoʻomaikaʻi ka spermidine meaʻai (i loaʻa i nā ʻano meaʻai like ʻole me ka soy a me nā palaoa) i ka hoʻomanaʻo i nā ʻiole. Pono ka noiʻi hou aku e hoʻoholo ai inā hiki ke hana hou ʻia kēia mau ʻike i loko o ke kanaka.
ʻO ke kaʻina hana ʻelemakule maʻamau e hōʻemi ana i ka nui o nā ʻano kūlohelohe o ka spermidine i loko o ke kino, e like me ka noiʻi i paʻi ʻia ma Scientific Reports e nā mea noiʻi ma ke Kulanui Lapaʻau ʻo Kyoto Prefectural ma Iapana. Eia naʻe, ʻaʻole i ʻike ʻia kēia hanana i nā kenekulia;
Hiki iā Spermidine ke hoʻoulu i ka autophagy.
ʻO nā meaʻai me ka nui o ka spermidine: nā meaʻai palaoa piha, kelp, nā halo shiitake, nā nati, ka bracken, ka purslane, a pēlā aku.
curcumin
ʻO Curcumin ka mea hana i loko o ka turmeric nona nā waiwai anti-inflammatory a me antioxidant.
Ua ʻike nā kānaka ʻepekema hoʻokolohua mai ka Polish Academy of Sciences hiki i ka curcumin ke hōʻemi i nā hōʻailona o ka ʻelemakule a hoʻopaneʻe i ka holomua o nā maʻi e pili ana i ka ʻelemakule kahi e pili pono ai nā cell senescent, a laila e hoʻolōʻihi ai i ke ola.
Ma waho aʻe o ka turmeric, ʻo nā meaʻai kiʻekiʻe i ka curcumin e komo pū me: ginger, kālika, ʻonika, pepa ʻeleʻele, mustard a me curry.
Nā mea hoʻohui NAD+
Ma kahi o nā mitochondria, aia ʻo NAD+ (nicotinamide adenine dinucleotide), kahi molekala e pono ai no ka hoʻonui ʻana i ka hana ikehu. Hoʻemi maoli ʻo NAD+ me ka ʻelemakule, kahi mea e kūlike me ka emi ʻana o ka hana mitochondrial e pili ana i ka makahiki. ʻO kēia kekahi o nā kumu i hoʻomohala ʻia ai nā mea hoʻoikaika NAD+ e like me NR (Nicotinamide Ribose) e hoʻihoʻi i nā pae NAD+.
Ua hōʻike ʻia nā noiʻi ma o ka hoʻolaha ʻana iā NAD+, hiki i ka NR ke hoʻonui i ka hana ikehu mitochondrial a pale i ke kaumaha e pili ana i ka makahiki. Hiki i nā mea hoʻohui precursor NAD+ ke hoʻomaikaʻi i ka hana ʻiʻo, ke olakino o ka lolo, a me ka metabolism me ka hakakā ʻana i nā maʻi neurodegenerative. Eia kekahi, hoʻemi lākou i ka loaʻa ʻana o ke kaumaha, hoʻomaikaʻi i ka ʻike o ka insulin, a hoʻomaʻamaʻa i nā pae lipid, e like me ka hoʻohaʻahaʻa ʻana i ka cholesterol LDL.
Ka manawa hoʻouna: Iulai-24-2024
