Ua ʻike nā kānaka ʻepekema i ko mākou mau makahiki, e emi mālie ko mākou mitochondria a hoʻemi iki i ka ikehu. Hiki i kēia ke alakaʻi i nā maʻi e pili ana i ka makahiki e like me nā maʻi neurodegenerative, maʻi naʻau, a me nā mea hou aku.
ʻO Urolithin A
ʻO Urolithin A kahi metabolite kūlohelohe me nā hopena antioxidant a me antiproliferative. Uaʻike nā meaʻai meaʻai mai ke Kulanuiʻo Nova Southeastern ma United States i ka hoʻohanaʻana i ka urolithin A ma keʻano he meaʻai meaʻai hiki ke hoʻopaneʻe i ke kaʻina hanaʻelemakule a pale i ka uluʻana o nā maʻi e pili ana i ka makahiki.
Hoʻokumu ʻia ka Urolithin A (UA) e ko mākou ʻōpū ma hope o ka ʻai ʻana i nā polyphenols i loaʻa i nā meaʻai e like me nā pomegerane, strawberries, a me nā walnuts. ʻO ka hoʻohui ʻana o UA i nā ʻiole waena o ka makahiki e hoʻāla i nā sirtuins a hoʻonui i ka NAD + a me nā pae ikehu cellular. ʻO ka mea nui, ua hōʻike ʻia ʻo UA e hoʻomaʻemaʻe i ka mitochondria i hōʻino ʻia mai nā ʻiʻo kanaka, a laila e hoʻomaikaʻi ai i ka ikaika, ka pale ʻana i ka luhi, a me ka hana haʻuki. No laila, hiki i ka UA supplementation ke hoʻolōʻihi i ke ola ma o ka pale ʻana i ka ʻelemakule ʻiʻo.
ʻAʻole hele pololei mai ʻo Urolithin A mai ka meaʻai, akā ʻo nā pūhui e like me ka ellagic acid a me nā ellagitannins i loko o nā nati, nā pomegerane, nā hua waina a me nā huaʻai ʻē aʻe e hoʻopuka i ka urolithin A ma hope o ka hoʻopili ʻia ʻana e nā microorganisms intestinal.
Spermidine
ʻO Spermidine kahi ʻano kūlohelohe o ka polyamine i loaʻa i ka nānā ʻana i nā makahiki i hala iho nei no kona hiki ke hoʻonui i ke ola a hoʻonui i ke olakino. E like me NAD + a me CoQ10, ʻo ka spermidine kahi mole kūlohelohe maoli e emi ana me ka makahiki. E like me UA, hana ʻia ka spermidine e ko mākou ʻōpū a hoʻoulu i ka mitophagy - ka wehe ʻana i ka mitochondria maikaʻi ʻole. Hōʻike nā haʻawina ʻiole hiki i ka spermidine supplementation ke pale aku i ka maʻi puʻuwai a me ka ʻelemakule hānau wahine. Eia kekahi, ʻo ka spermidine meaʻai (loaʻa i nā ʻano meaʻai like ʻole me ka soy a me nā kīʻaha) i hoʻomaikaʻi i ka hoʻomanaʻo ʻana i nā ʻiole. Pono ka noiʻi hou aʻe e hoʻoholo ai inā hiki ke hana hou ʻia kēia mau ʻike i ke kanaka.
ʻO ke kaʻina hana maʻamau e hōʻemi i ka ʻike o nā ʻano kūlohelohe o spermidine i loko o ke kino, e like me ka noiʻi i paʻi ʻia ma Scientific Reports e nā mea noiʻi ma Kyoto Prefectural University of Medicine ma Iapana. Eia naʻe, ʻaʻole i ʻike ʻia kēia ʻano i nā centenarians;
Hiki i ka Spermidine ke hoʻoikaika i ka autophagy.
ʻO nā meaʻai me ke kiʻekiʻe o ka spermidine ʻo ia hoʻi: nā meaʻai palaoa holoʻokoʻa, kelp, shiitake mushrooms, nati, bracken, purslane, etc.
curcumin
ʻO Curcumin ka mea ikaika i ka turmeric i loaʻa nā waiwai anti-inflammatory a me nā antioxidant.
Ua ʻike nā mea olaola hoʻokolohua mai ka Polish Academy of Science e hiki i ka curcumin ke hōʻemi i nā hōʻailona o ka ʻelemakule a hoʻopaneʻe i ka piʻi ʻana o nā maʻi e pili ana i ka makahiki e pili pono ana nā cell senescent, a laila e hoʻolōʻihi i ke ola.
Ma waho aʻe o ka turmeric, ʻo nā meaʻai kiʻekiʻe i ka curcumin ka: ginger, garlic, aniani, ʻeleʻele pepa, sinapi a me ka curry.
Nā mea hoʻohui NAD+
Ma kahi o mitochondria, aia ka NAD + (nicotinamide adenine dinucleotide), he mole e pono ai no ka hoʻonui ʻana i ka ikehu. Ua emi maoli ka NAD + me ka makahiki, e like me ka emi ʻana o ka makahiki i ka hana mitochondrial. ʻO kēia kekahi o nā kumu i hoʻomohala ʻia ai ka NAD + boosters e like me NR (Nicotinamide Ribose) e hoʻihoʻi i nā pae NAD +.
Hōʻike ka noiʻi ma ka hoʻolaha ʻana i ka NAD +, hiki i ka NR ke hoʻonui i ka hana ikehu mitochondrial a pale i ke kaumaha pili makahiki. Hiki i nā mea hoʻohui precursor NAD + ke hoʻomaikaʻi i ka hana o ka ʻiʻo, ke olakino lolo, a me ka metabolism ʻoiai e hakakā ana i nā maʻi neurodegenerative. Hoʻohui, hoʻemi lākou i ka loaʻa kaumaha, hoʻomaikaʻi i ka naʻau o ka insulin, a hoʻomaʻamaʻa i nā pae lipid, e like me ka hoʻohaʻahaʻa ʻana i ka LDL cholesterol.
Ka manawa hoʻouna: Iulai-24-2024