Salidroside: Ke wehe nei i ka mea huna o nā waiwai antioxidant o Rhodiola rosea

ʻO Salidroside he antioxidant kūlohelohe ia e pale ai i nā pūnaewele nerve ma o ka scavenging ROS a me ke kāohi ʻana i ka apoptosis cell.

ʻO ka nui o ka calcium intracellular kekahi o nā kumu nui o ka apoptosis neuronal. Hiki i ka Rhodiola rosea extract a me ka salidroside ke hōʻemi i ka hoʻonui ʻia o nā pae calcium manuahi intracellular i hoʻokumu ʻia e ke kaumaha oxidative a pale i nā cell cortical kanaka mai ka glutamate. Hiki i ka Salidroside ke kāohi i ka hoʻāla ʻana o ka microglial i hoʻokumu ʻia e ka lipopolysaccharide, kāohi i ka hana NO, kāohi i ka hana inducible nitric oxide synthase (iNOS), a hōʻemi i nā pae TNF-α a me IL-1β, IL-6.

Hoʻopaʻa ʻo Salidroside i ka NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) a me ka mea hoʻoponopono pane o ka hoʻomohala ʻana a me ka hōʻino DNA 1 (REDD1)/mammalian target o rapamycin (mTOR)/p70 ribosome Hoʻāla ke ala hōʻailona protein S6 kinase i ka AMP-dependent protein kinase/silent information regulator 1, RAS homologous gene family member A/MAPK a me PI3K/Akt signaling pathways.

1. Hoʻopilikia ʻo Salidroside i ka hōʻino radical manuahi a pale i ke kino

Hiki i ke kino ke hana i kahi nui o nā radical manuahi endogenous i ka wā o nā kaʻina hana physiological maʻamau, a pono kahi mahele physiological o nā radical manuahi e mālama i nā hana physiological maʻamau o ke kino. Aia kekahi ʻōnaehana scavenging radical manuahi i loko o ke kino e wehe i nā radical manuahi e ʻoi aku ma mua o nā mahele physiological i ʻole e hōʻeha i ke olakino o ke kino.

Eia nō naʻe, ma lalo o ka mana o kekahi mau mea pili i ke kaiapuni, e nui loa nā radical manuahi o ke kino a ʻoi aku ma mua o ka nui o ka ʻōnaehana e hoʻopau ai i nā radical manuahi, e hana ana i kahi kaulike ʻole i loko o ka ʻōnaehana hana-scavenging radical manuahi o ke kino, e alakaʻi ana i ka hōʻiliʻili ʻana o nā radical manuahi oxygen i loko o ke kino, a laila e hōʻino ai i ka membrane cell.

Ua hōʻike ʻia nā noiʻi e hiki i ke kaiapuni hypoxic ma lalo o nā kūlana plateau ke hana i kahi kaulike ʻole i ka metabolism radical oxygen-free, e hōʻiliʻili ana i nā radical free intracellular a hoʻonui i nā huahana lipid peroxidation. Ua hōʻike ʻia nā noiʻi e hiki i ka salidroside ke pale i nā cell tissue ma o ka scavenging free radicals i loko o ke kino.

2. ʻO Salidroside kū'ē i ka hypoxia e mālama i ke kūpaʻa o ka hana mitochondrial

Ma kahi o 80-90% o ka oxygen intracellular e hoʻohana ʻia no ka oxidation biological i loko o mitochondria e hana i ka ATP a hoʻokumu i nā ʻano oxygen reactive ROS e mālama i nā hana ola maʻamau o nā cell. ʻO 10-20% wale nō o ka oxygen i manuahi ma waho o ka mitochondria no ka biosynthesis, degradation, biotransformation (detoxification), a pēlā aku. Hoʻonui ʻia ka hana hanu mitochondrial i ka hypoxia akahai a i ʻole i ke kahua mua o ka hypoxia, kahi i hōʻike ʻia ma ke ʻano he pane compensatory o ka ʻōnaehana hanu o ke kino.

ʻO ka hypoxia koʻikoʻi e hoʻopilikia mua i ka oxygenation o waho o mitochondria a me nā maʻi metabolic hana o ke kino, e hōʻemi i ka hana ʻana o nā neurotransmitters, a hoʻonāwaliwali i nā hiki biotransformation, a laila e hoʻopilikia ai i nā hana o nā ʻiʻo a me nā ʻōpū. Ua hōʻike ʻia nā haʻawina e hiki i ka salidroside ke pale i ka mālama ʻana i ka hana mitochondrial ma ka hōʻemi ʻana i ka nui o ROS i loko o nā mitochondria cell, e hoʻonui ana i ka hana SOD, a me ka hoʻonui ʻana i ka helu o nā mitochondria.

3. Ka hopena palekana myocardial o salidroside

Ua hōʻike ʻia nā haʻawina ʻo ka ʻōnaehana cardiovascular ka ʻōnaehana nui e hoʻololi ai i kahi kaiapuni hypoxic. ʻO kahi kaiapuni hypoxic e hoʻonāwaliwali i ka metabolism aerobic o ke kino a me ka lawa ʻole o ka lako ikehu, e alakaʻi ana i nā hōʻailona e like me ka hypoxia, ischemia, a me ka apoptosis o nā cell myocardial. Ua hōʻike ʻia nā haʻawina hiki i ka salidroside ke hoʻoikaika i ka hana cardiac a hoʻomaikaʻi i ka microcirculation ma ka hoʻonui ʻana i nā kīʻaha koko arterial a me venous, hoʻomaikaʻi i ka perfusion koko myocardial, hoʻololi i ka hemodynamics o ka puʻuwai, hoʻemi i ka ukana cardiac, a me ka hoʻēmi ʻana i ka pōʻino ischemic myocardial.
I ka pōkole, hiki i ka salidroside ke hana ma ka ʻōnaehana cardiovascular ma o nā ʻano hana he nui, nā ala, a me nā pahuhopu, pale i ka apoptosis cell myocardial i hoʻokumu ʻia e nā kumu he nui, a hoʻomaikaʻi i nā kūlana ischemia a me hypoxia o ke kino. I loko o kahi kaiapuni hypoxic, he mea nui ka hana a Rhodiola rosea i ka pale ʻana i nā ʻiʻo a me nā ʻōpū o ke kino a me ka mālama ʻana i ke kūpaʻa o nā hana cell. He kuleana koʻikoʻi kāna i ka pale ʻana a me ka hōʻoluʻolu ʻana i ka maʻi kiʻekiʻe.
Ke kūlana o kēia manawa o ka hana ʻana o salidroside

1) Hilinaʻi nui ʻia ma ka unuhi ʻana i nā mea kanu

ʻO Rhodiola rosea ka mea kanu maka osalidroside.Ma ke ʻano he ʻano mea kanu mau loa, ulu nui ʻo Rhodiola rosea ma nā wahi me ke anu kiʻekiʻe, ka ʻino, ka maloʻo, a me ka ʻokoʻa nui o ka mahana ma waena o ke ao a me ka pō ma kahi kiʻekiʻe o 1600-4000 mika. ʻO ia kekahi o nā mea kanu pāpū hihiu. ʻO Kina kekahi o nā wahi hana nui o Rhodiola rosea ma ka honua, akā he mea kūikawā loa nā ʻano ola o Rhodiola rosea. ʻAʻole wale ka paʻakikī o ka mahi ʻana i ka hana artificial, akā haʻahaʻa loa ka hua o nā ʻano hihiu. ʻO ka palena o ka noi makahiki no Rhodiola rosea he 2,200 tons.

2) Hoʻohuihui kemika a me ka hoʻoulu ʻana o ka meaola

Ma muli o ka haʻahaʻa o ka ʻike a me ke kumukūʻai hana kiʻekiʻe i nā mea kanu, me nā ʻano unuhi kūlohelohe, ʻo nā ʻano hana hana salidroside e komo pū me nā ʻano hana synthesis kemika, nā ʻano hana fermentation biological, a me nā mea ʻē aʻe. I waena o lākou, i ka hoʻomau ʻana o ka ʻenehana i ka oʻo ʻana, ua lilo ka fermentation biological i ke ala loea nui no ka hoʻomohala noiʻi a me ka hana ʻana o salidroside. I kēia manawa, ua hoʻokō ʻo Suzhou Mailun i nā hopena noiʻi a me ka hoʻomohala ʻana a ua hoʻokō i ka ʻoihana.