ʻO Salidroside ka mea hana nui i lawe ʻia mai Rhodiola rosea a loaʻa iā ia nā ʻano mea olaola a me ka pharmacological. Loaʻa i ka Salidroside ka hopena o ka pale ʻana i ke koʻikoʻi oxidative, ke kāohi ʻana i ka apoptosis cell, a me ka hōʻemi ʻana i nā hopena inflammatory.
Salidroside he antioxidant kūlohelohe ia e pale ana i nā pūnaewele aʻalolo ma ka scavenging ROS a me ka pale ʻana i ka apoptosis cell.
ʻO ka overload calcium intracellular kekahi o nā kumu nui o ka apoptosis neuronal. Hiki i ka Rhodiola rosea extract a me ka salidroside ke hōʻemi i ka piʻi ʻana o ka nui o ka nui o ka calcium manuahi intracellular i hoʻoulu ʻia e ke koʻikoʻi oxidative a pale i nā cell cortical kanaka mai ka glutamate. Hiki i ka Salidroside ke kāohi i ka lipopolysaccharide-induced microglial activation, inhibit NO production, inhibit inducible nitric oxide synthase (iNOS), a ho'ēmi i TNF-α a me IL-1β , IL-6 pae.
Hoʻopaʻa ʻo Salidroside i ka NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) a me ka mea hoʻoponopono pane o ka hoʻomohala ʻana a me ka hōʻino DNA 1 (REDD1) / ka pahu momona o ka rapamycin (mTOR)/p70 ribosome ʻO ka protein S6 kinase hōʻailona ala e hoʻāla ai i ka AMP-dependent. protein kinase/ka hoʻoponopono ʻike leo 1, RAS homologous gene family member A/MAPK a me PI3K/Akt ala hōʻailona.
1. Hoʻopilikia ʻo Salidroside i ka pōʻino radical manuahi a pale i ke kino
Hiki i ke kino ke hana i ka nui o nā radical free endogenous i ka wā o nā kaʻina hana physiological maʻamau, a pono ke ʻano physiological o nā radical manuahi e mālama i nā hana physiological maʻamau o ke kino. Aia kekahi ʻōnaehana hoʻoheheʻe radical manuahi i loko o ke kino e hoʻopau i nā radical manuahi i ʻoi aku ma mua o nā doses physiological i ʻole e pōʻino i ke olakino o ke kino.
Eia nō naʻe, ma lalo o ka mana o kekahi mau mea kaiapuni kūikawā, e ʻoi aku ka nui o nā radical manuahi endogenous o ke kino a ʻoi aku ma mua o ka nui o ka scavenging radical manuahi o ka ʻōnaehana. i loko o ke kino, a laila e hōʻino ai i ka membrane cell. poino.
Hōʻike ka noiʻi e hiki i ke kaiapuni hypoxic ma lalo o nā kūlana plateau ke hoʻoulu i kahi imbalance i ka metabolism radical free oxygen, hōʻiliʻili i nā radical manuahi intracellular a me ka hoʻonui ʻana i nā huahana peroxidation lipid. Ua hōʻike ʻia nā haʻawina e hiki i ka salidroside ke pale i nā cell tissue ma ka ʻohi ʻana i nā radical manuahi i ke kino.
2. Salidroside antagonizes hypoxia e mālama i ka paʻa o ka hana mitochondrial
Ma kahi o 80-90% o ka oxygen intracellular e hoʻohana ʻia no ka oxidation biological i ka mitochondria e hana i ka ATP a hana i nā ʻano oxygen reactive ROS e mālama i nā hana ola maʻamau o nā cell. ʻO 10-20% wale nō ka oxygen ma waho o ka mitochondria no ka biosynthesis, degradation, biotransformation (detoxification), etc. ʻōnaehana hanu o ke kino.
ʻO ka hypoxia koʻikoʻi e hoʻopilikia mua i ka oxygenation waho o ka mitochondria a me nā maʻi metabolic hana o ke kino, e hōʻemi i ka hana ʻana o nā neurotransmitters, a hoʻonāwaliwali i ka hiki ke biotransformation, a laila e hoʻopilikia i nā hana o nā ʻiʻo a me nā kino. Ua hōʻike nā haʻawina e hiki i ka salidroside ke pale i ka mālama ʻana i ka hana mitochondrial ma o ka hōʻemi ʻana i ka ʻike ROS i loko o ka cell mitochondria, hoʻonui i ka hana SOD, a me ka hoʻonui ʻana i ka helu o ka mitochondria.
3. ʻO ka hopena pale o ka myocardial o salidroside
Ua hōʻike nā haʻawina ʻo ka ʻōnaehana cardiovascular ka ʻōnaehana nui e hoʻololi i kahi ʻano hypoxic. ʻO kahi kaiapuni hypoxic e hoʻonāwaliwali ai ke kino aerobic metabolism a lawa ʻole ka lako ikehu, e alakaʻi ana i nā hōʻailona e like me ka hypoxia, ischemia, a me ka apoptosis o nā pūnaewele myocardial. Ua hōʻike nā haʻawina e hiki i ka salidroside ke hoʻonui i ka hana cardiac a hoʻomaikaʻi i ka microcirculation ma o ka hoʻonui ʻana i nā kīʻaha koko a me nā venous, hoʻomaikaʻi i ke kahe koko myocardial, hoʻololi i ka hemodynamics o ka puʻuwai, hoʻemi i ka ukana puʻuwai, a hoʻemi i ka pōʻino ischemic myocardial.
I ka pōkole, hiki i ka salidroside ke hana i ka ʻōnaehana cardiovascular ma o nā mīkini he nui, nā ala, a me nā pahuhopu, pale i ka myocardial cell apoptosis i hoʻokumu ʻia e nā kumu he nui, a hoʻomaikaʻi i ka ischemia a me nā kūlana hypoxia o ke kino. I loko o kahi kaiapuni hypoxic, he mea koʻikoʻi ka hana ʻana o Rhodiola rosea i ka pale ʻana i nā ʻiʻo a me nā ʻāpana o ke kino a me ka mālama ʻana i ka paʻa o nā hana cell. He kuleana koʻikoʻi ia i ka pale ʻana a me ka hoʻēmi ʻana i ka maʻi kiʻekiʻe.
ʻO ke kūlana o kēia manawa o ka hana salidroside
1) E hilinaʻi nui i ka unuhi ʻana i nā mea kanu
ʻO Rhodiola rosea ka mea maka osalidroside.E like me ke ʻano o ka mea kanu herbaceous perennial, ulu nui ʻo Rhodiola rosea i nā wahi me ke anuanu kiʻekiʻe, anoxia, maloʻo, a me ka ʻokoʻa wela nui ma waena o ke ao a me ka pō ma kahi kiʻekiʻe o 1600-4000 mika. ʻO ia kekahi o nā mea kanu pāpū hihiu. ʻO Kina kekahi o nā wahi hana nui o Rhodiola rosea ma ka honua, akā kūikawā nā ʻano ola o Rhodiola rosea. ʻAʻole wale ka paʻakikī o ka mahiʻai ʻana, akā haʻahaʻa loa ka hua o nā ʻano hihiu. ʻO ke kiʻekiʻe o ke koi makahiki no Rhodiola rosea he 2,200 tons.
2) Hoʻohui kemika a me ka fermentation biological
Ma muli o ka haʻahaʻa haʻahaʻa a me ke kumukūʻai kiʻekiʻe o ka hana ʻana i nā mea kanu, ma waho aʻe o nā ʻano unuhi kūlohelohe, nā ʻano hana hana salidroside pū kekahi me nā ʻano synthesis kemika, nā ʻano fermentation biological, a me nā mea ʻē aʻe. ala ʻenehana no ka hoʻomohala noiʻi a me ka hana ʻana o salidroside. I kēia manawa, ua hoʻokō ʻo Suzhou Mailun i nā hopena noiʻi a me ka hoʻomohala ʻana a ua hoʻokō i ka ʻenehana.
Hoʻopau: No ka ʻike maʻamau wale nō kēia ʻatikala a ʻaʻole pono e manaʻo ʻia he ʻōlelo aʻoaʻo olakino. Loaʻa mai kekahi o ka ʻike moʻomanaʻo blog mai ka Pūnaewele a ʻaʻole ʻoihana. ʻO kēia pūnaewele wale nō ke kuleana no ka hoʻokaʻawale ʻana, ka hoʻopili ʻana a me ka hoʻoponopono ʻana i nā ʻatikala. ʻO ke kumu o ka hāʻawi ʻana i nā ʻike hou aʻe ʻaʻole ia he manaʻo ʻae ʻoe i kāna mau manaʻo a hōʻoia paha i ka ʻoiaʻiʻo o kāna ʻike. E nīnau mau i kahi ʻoihana mālama ola ma mua o ka hoʻohana ʻana i nā mea hoʻohui a i ʻole ka hoʻololi ʻana i kāu ʻano mālama ola kino.
Ka manawa hoʻouna: ʻAukake-15-2024
