Mea hoʻohui meaʻai-He mea hou no ka lōʻihi o ke ola a me ka anti-kahiko: Calcium Alpha-ketoglutarate

Kalima Alpha ketoglutarate ʻO (AKG) kahi metabolite waena o ka pōʻaiapuni waikawa tricarboxylic a komo i ka synthesizing amino acids, vitamins, a me nā waikawa organik a me ka metabolism ikehu. Hiki ke hoʻohana ʻia ma ke ʻano he mea hoʻohui meaʻai a he mau manaʻolana noi ākea. Ma waho aʻe o kāna mau hana olaola i loko o ke kino o ke kanaka, hoʻohana nui ʻia ka calcium alpha-ketoglutarate i ke kahua lāʻau lapaʻau a ua lilo ia i ʻāpana koʻikoʻi o nā huahana olakino a me nā hopena lapaʻau.

Pehea e hana ai ka calcium alpha-ketoglutarate

Ka mua,cʻalcium alpha-ketoglutarateHe kuleana koʻikoʻi ko ia i ka metabolism ikehu. Ma ke ʻano he huahana waena o ka pōʻaiapuni waikawa tricarboxylic (TCA cycle), komo ka calcium α-ketoglutarate i ke kaʻina hana ikehu intracellular. Ma o ke pōʻaiapuni TCA, ua hoʻopau ʻia a hoʻoheheʻe ʻia nā meaʻai e like me nā kalapona, nā momona, a me nā protein e hana i ka ATP (adenosine triphosphate) e hāʻawi i ka ikehu no nā cell. Ma ke ʻano he waena koʻikoʻi i ka pōʻaiapuni TCA, hiki i ka calcium α-ketoglutarate ke hoʻolaha i ka metabolism ikehu cell, hoʻonui i ka pae ikehu o ke kino, kōkua i ka hoʻoikaika ʻana i ka ikaika kino a me ke ahonui, a hoʻomaikaʻi i ka luhi kino.

ʻO ka lua, he kuleana koʻikoʻi ko ka calcium α-ketoglutarate i ka metabolism amino acid. ʻO nā waikawa Amino nā ʻāpana kumu o ka protein, a pili ka calcium α-ketoglutarate i ka hoʻololi a me ka metabolism o nā waikawa amino. I ke kaʻina hana o ka hoʻololi ʻana i nā waikawa amino i nā metabolites ʻē aʻe, transaminates ka calcium α-ketoglutarate me nā waikawa amino e hana i nā waikawa amino hou a i ʻole nā ​​​​waikawa α-keto, no laila e hoʻoponopono ana i ke kaulike a me ka hoʻohana ʻana o nā waikawa amino. Eia kekahi, hiki i ka calcium α-ketoglutarate ke lawelawe ma ke ʻano he substrate oxidation no nā waikawa amino, komo i ka metabolism oxidative o nā waikawa amino, a hana i ka ikehu a me ke kalapona dioxide. No laila, he mea nui ka calcium α-ketoglutarate i ka mālama ʻana i ka homeostasis o nā waikawa amino a me ka metabolism protein i loko o ke kino.

Eia kekahi, hana ka calcium alpha-ketoglutarate ma ke ʻano he antioxidant e hoʻopau i nā radical manuahi a pale i nā cell mai ka pōʻino oxidative. I ka manawa like, hiki i ka calcium α-ketoglutarate ke hoʻoponopono i ka hana o ka ʻōnaehana pale, paipai i ka hoʻoulu ʻana a me ka hoʻonui ʻana o nā cell pale, a hoʻoikaika i ke kūʻē ʻana o ke kino i nā maʻi a me ka maʻi. No laila, he mea nui ka calcium α-ketoglutarate i ka mālama ʻana i ke kaulike o ke kino a me ke kūʻē ʻana i nā maʻi.

Noiʻi e pili ana i nā hopena o ka ʻelemakule

Hoʻopilikia ka ʻelemakule iā kākou āpau a he kumu pilikia ia no nā maʻi he nui, a e like me ka demographics o ka ʻoihana Medicare, piʻi ka likelika o ka loaʻa ʻana o ka maʻi me ka makahiki. I mea e hōʻoluʻolu ai i ka ʻelemakule a hoʻemi pono i ka pilikia o ka maʻi, ua ʻike ka noiʻi i kahi mea palekana a bioactive e hiki ke hoʻopilikia i ka ʻelemakule - calcium alpha-ketoglutarate.

He metabolite koʻikoʻi ka calcium alpha-ketoglutarate i loko o ko mākou kino, i ʻike ʻia no ke kuleana o ke kelepona i loko o ke kaʻina hana Krebs, kahi kaʻina hana e pono ai no ka hoʻoheheʻe ʻia ʻana o nā waikawa momona a me nā waikawa amino, e ʻae ana i ka mitochondria e hana i ka ATP (ʻo ATP ke kumu ikehu o nā kelepona).

Pili kēia i ka hoʻouka ʻana o ke kaʻina hana calcium alpha-ketoglutarate, no laila hiki ke hoʻololi ʻia ka calcium alpha-ketoglutarate i glutamate a laila i glutamine, hiki ke kōkua i ka hoʻoulu ʻana i ka synthesis o ka protein a me ka collagen (ʻo ka collagen kahi protein fibrous e hana ana i ka 1/3 o nā protein āpau i ke kino a kōkua i ke kākoʻo ʻana i ka iwi, ka ʻili a me ke olakino ʻiʻo).

ʻO Ponce De Leon Health, Inc., kahi ʻoihana noiʻi lōʻihi e kālele ana i ka hoʻohuli ʻana i ka ʻelemakule genetic, ua hana i kahi noiʻi i kāohi ʻia he mau makahiki he nui o ka calcium alpha-ketoglutarate ma nā ʻiole waena a ua ʻike ʻia ua piʻi ke ola o nā ʻiole i ka hui hoʻokolohua ma 12%. ʻOi aku ka mea nui, ʻo ka mea hou aku, ua hoʻemi ʻia ka nāwaliwali ma 46% a ua piʻi ke ola olakino ma 41%. Hōʻike nā hōʻike e hiki ʻole i ka hoʻohui alpha-ketoglutarate ke hoʻolōʻihi wale i ke ola akā e hoʻolōʻihi pū i ke olakino ma kahi ākea.

ʻO ka Calcium α-ketoglutarate, ma ke ʻano he mea hoʻohui meaʻai multifunctional, he nui nā manaʻolana no ka hoʻohana ʻana i nā huahana mālama ola. ʻO kāna mau hana olaola like ʻole e like me ka antioxidant, anti-aging, immune regulation a me ka amino acid metabolism e lilo ia i mea hana ikaika e hoʻomaikaʻi ai i ke olakino kanaka. Me ka hoʻonui ʻana o ka ʻike i ka mālama ola a me ka hoʻoikaika ʻana i ka noiʻi ʻepekema, ua manaʻoʻiʻo ʻia e loaʻa hou aku ka nānā a me ka hoʻomohala ʻana i ka hoʻohana ʻana o ka α-ketoglutarate calcium ma ke kahua o nā huahana mālama ola.