Pākuʻi meaʻai-mea hou no ka lōʻihi a me ka anti-kahiko: Calcium Alpha-ketoglutarate

Calcium Alpha ketoglutarate (AKG) he metabolite waena o ka pōʻai ʻakika tricarboxylic a komo i ka synthesizing i nā waikawa amino, nā huaora, a me nā waikawa organik a me ka metabolism ikehu. Hiki ke hoʻohana ʻia ma ke ʻano he meaʻai meaʻai a loaʻa nā manaʻo ākea ākea. Ma kahi o kāna mau hana olaola i loko o ke kino kanaka, hoʻohana nui ʻia ka calcium alpha-ketoglutarate i ka lāʻau lapaʻau a ua lilo ia i mea nui o nā huahana olakino a me nā hoʻonā olakino.

Pehea ka hana ʻana o ka calcium alpha-ketoglutarate

Ka mua,cka ʻaleʻa alpha-ketoglutaratehe kuleana koʻikoʻi i ka metabolism ikehu. Ma ke ʻano he huahana waena o ka tricarboxylic acid cycle (TCA cycle), ke komo nei ka calcium α-ketoglutarate i ke kaʻina hana o ka ikehu intracellular. Ma o ka pōʻaiapuni TCA, ua hoʻoheheʻe ʻia nā meaʻai e like me ka carbohydrates, nā momona, a me nā protein e hoʻohua ai i ka ATP (adenosine triphosphate) e hāʻawi i ka ikehu no nā cell. Ma ke ʻano he koʻikoʻi koʻikoʻi i ka pōʻai TCA, hiki i ka calcium α-ketoglutarate ke hoʻoikaika i ka metabolism ikehu cell, hoʻonui i ka pae ikehu o ke kino, kōkua i ka hoʻoikaika kino kino a me ka hoʻomanawanui, a hoʻomaikaʻi i ka luhi kino.

ʻO ka lua, he mea nui ka calcium α-ketoglutarate i ka metabolism amino acid. ʻO nā amino acids nā ʻāpana kumu o ka protein, a ua komo ka calcium α-ketoglutarate i ka hoʻololi ʻana a me ka metabolism o nā waikawa amino. I ke kaʻina hana o ka hoʻololi ʻana i nā waikawa amino i nā metabolites ʻē aʻe, hoʻololi ka calcium α-ketoglutarate me nā waikawa amino e hana i nā waikawa amino hou a i ʻole α-keto acids, pēlā e hoʻoponopono ai i ke koena a me ka hoʻohana ʻana i nā waikawa amino. Eia kekahi, hiki i ka calcium α-ketoglutarate ke lawelawe ma ke ʻano he substrate oxidation no nā amino acids, komo i ka metabolism oxidative o nā amino acids, a hana i ka ikehu a me ka carbon dioxide. No laila, he mea nui ka calcium α-ketoglutarate i ka mālama ʻana i ka homeostasis o nā waikawa amino a me ka metabolism protein i ke kino.

Eia kekahi, hana ka calcium alpha-ketoglutarate ma ke ʻano he antioxidant e hōʻemi ana i nā radical manuahi a pale i nā cell mai ka pōʻino oxidative. I ka manawa like, hiki i ka calcium α-ketoglutarate ke hoʻoponopono i ka hana o ka ʻōnaehana pale, hoʻoikaika i ka hoʻoulu ʻana a me ka hoʻonui ʻana o nā cell immune, a hoʻonui i ke kūʻē o ke kino i ka maʻi a me ka maʻi. No laila, he koʻikoʻi nui ka calcium α-ketoglutarate i ka mālama ʻana i ka pale pale pale o ke kino a me ka pale ʻana i nā maʻi.

E noiʻi i nā hopena o ka ʻelemakule

Hoʻopilikia ka ʻelemakule iā mākou a pau a he kumu pilikia ia no nā maʻi he nui, a e like me ka ʻoihana Medicare demographics, piʻi ka nui o ka ulu ʻana o ka maʻi me ka makahiki. I mea e hōʻoluʻolu ai i ka ʻelemakule a hoʻemi pono i ka hopena o ka maʻi, ua ʻike ka noiʻi i kahi mea palekana a bioactive hiki ke hoʻopilikia i ka wā kahiko - calcium alpha-ketoglutarate.

ʻO ka calcium alpha-ketoglutarate he metabolite koʻikoʻi i loko o ko mākou kino, i ʻike ʻia no ke kuleana o ke kelepona i ka pōʻaiapili Krebs, kahi pōʻai pono no ka hoʻoheheʻe ʻana o nā momona momona a me nā waikawa amino, e ʻae ai i ka mitochondria e hana i ka ATP (ʻo ATP ke kumu ikehu o nā cell).

Hoʻopili kēia i ka hoʻouka ʻana i ke kaʻina hana calcium alpha-ketoglutarate, no laila hiki ke hoʻololi ʻia ka calcium alpha-ketoglutarate i glutamate a laila i glutamine, hiki ke kōkua i ka hoʻoulu ʻana i ka synthesis o ka protein a me ka collagen (ʻo ka collagen he protein fibrous e hana i ka 1/3 o nā protein a pau i loko o ke kino a kōkua i ke ola o ka iwi, ka ʻili a me ka ʻiʻo).

ʻO Ponce De Leon Health, Inc., kahi hui noiʻi lōʻihi e kālele ana i ka hoʻohuli ʻana i ka ʻelemakule genetic, ua alakaʻi i kahi noiʻi hoʻopaʻa ʻia o ka calcium alpha-ketoglutarate i nā ʻiole waena a ʻike ʻia ua hoʻonui ʻia ke ola o nā ʻiole i ka hui hoʻokolohua. 12%. ʻO ka mea nui aku, ʻO ka mea hou aku, ua hoʻemi ʻia ka nāwaliwali e 46% a ua hoʻonui ʻia ke ola olakino e 41%. Hōʻike nā hōʻike hōʻike ʻaʻole hiki i ka supplementation alpha-ketoglutarate ke hoʻolōʻihi i ke ola akā e hoʻonui i ke ola olakino.

ʻO ka calcium α-ketoglutarate, ma ke ʻano he meaʻai meaʻai multifunctional, loaʻa nā manaʻo ākea ākea i nā huahana mālama olakino. ʻO kāna mau hana olaola like ʻole e like me antioxidant, anti-aging, immune regulation a me amino acid metabolism e lilo ia i mea ikaika e hoʻomaikaʻi ai i ke olakino kanaka. Me ka hoʻonui ʻana i ka ʻike o ka mālama olakino a me ka hohonu o ka noiʻi ʻepekema, ua manaʻo ʻia ʻo ka noi ʻana o ka calcium α-ketoglutarate i ke kula o nā huahana mālama olakino e loaʻa hou ka nānā a me ka hoʻomohala ʻana.