Agomelatine pauka mea hana CAS No.: 138112-76-2 99% maemae min. no nā mea hoʻohui
Video Huahana
Nā Kūlana Huahana
| inoa huahana | Agomelatine |
| inoa ʻē aʻe | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| CAS No. | 138112-76-2 |
| ʻAno molekala | C15H17NO2 |
| Kaumaha molekula | 243.3082 |
| Maemae | 99.0% |
| Ka nana aku | Pauda keʻokeʻo |
| Hoʻopili | 1kg / ʻeke 25kg / pahu |
| Palapala noi | ʻO nā mea ola olakino |
Hoʻolauna huahana
Ua hoʻokuʻu mua ʻia ʻo Agomelatine ma ʻEulopa ma 2009 a ua ʻae ʻia i kēia manawa no ka hoʻohana ʻana ma nā ʻāina ʻoi aku ma mua o 70. ʻAʻole like me nā antidepressants kuʻuna, hana ʻo agomelatine ma ka huli ʻana i ka melatonin a me ka serotonin receptors i ka lolo. Ma ka hana ʻana ma ke ʻano he agonist i ka melatonin receptors, kōkua ʻo agomelatine i ka hoʻomaʻamaʻa ʻana i nā hiʻohiʻona hiamoe i hoʻopilikia pinepine ʻia me ke kaumaha. ʻAʻole kōkua kēia ʻano hana i ka hoʻomaikaʻi ʻana i ka maikaʻi o ka hiamoe akā kōkua pū kekahi i ka hoʻihoʻi ʻana i nā mele circadian kūlohelohe. Eia kekahi, hana ʻo agomelatine ma ke ʻano he antagonist ma kekahi mau mea loaʻa serotonin (5-HT2C receptors). ʻO kēia hana ʻelua ʻokoʻa e hoʻonui i ka loaʻa o ke serotonin i loko o ka lolo, kahi neurotransmitter kuleana no ka hoʻoponopono ʻana i ke ʻano. Ma ka hoʻoponopono ʻana i nā pae serotonin, hiki i ka agomelatine ke hana ma ke ʻano he antidepressant maikaʻi, hoʻomaha i nā hōʻailona e like me ke kaumaha, ka nalowale o ka hoihoi, nā manaʻo o ka hewa a i ʻole ka waiwai ʻole. Eia kekahi, hiki i ka agomelatine ke hāʻawi i nā pono ʻē aʻe. Hōʻike ka noiʻi hiki ke kōkua i ka hoʻomaikaʻi ʻana i ka hana noʻonoʻo.
Hiʻona
(1) Maʻemaʻe kiʻekiʻe: Hiki iā Agomelatine ke loaʻa nā huahana maʻemaʻe kiʻekiʻe ma o ka hoʻomaʻemaʻe ʻana i nā kaʻina hana. ʻO ka maʻemaʻe kiʻekiʻe, ʻoi aku ka maikaʻi o ka bioavailability a me ka liʻiliʻi o nā hopena ʻino.
(2) Palekana: Palekana kiʻekiʻe, liʻiliʻi nā hopena ʻino.
(3) Paʻa: He kūpaʻa maikaʻi ʻo Agomelatine a hiki ke mālama i kāna hana a me ka hopena ma lalo o nā kaiapuni like ʻole a me nā kūlana mālama.
Nā noi
ʻO Agomelatine he mea hōʻeha a me ka melatonin antagonist. Hoʻemi ia i nā hōʻailona depressive ma o ka hoʻoponopono ʻana i nā mea loaʻa melatonin MT1 (hōʻemi i nā hōʻailona alarm cortical) a me nā mea loaʻa MT2 (circadian sleep rhythm) a me nā pae serotonin. Lawe ʻia i ka pō, hoʻohālike ia i ke kani kūlohelohe o ka hoʻokuʻu ʻana o ka melatonin a hiki ke hoʻomaikaʻi nui i ka maikaʻi o ka hiamoe. ʻO kāna hana o ka hana e haki i ka ʻōnaehana hoʻouna monoamine kuʻuna. Hoʻoulu ia i nā mea loaʻa melatonin MT1 a me MT2 a kū'ē i nā mea loaʻa 5-HT2C. Hoʻomaikaʻi i ka maikaʻi o ka hiamoe, hoʻihoʻi i ke kani olaola, a he hopena antidepressant; i waena o lākou, ma ka hoʻopaʻapaʻa ʻana i nā mea hoʻokipa 5-HT2C ma ka membrane postsynaptic, hiki ke hoʻonui i ka hoʻokuʻu ʻana o DA a me NE i ka cortex prefrontal, e hana ana i kahi hopena antidepressant. Ke noho pū nei ka MT agonism a me ka 5-HT2C receptor antagonism, hiki ke hana ʻia kahi hopena synergistic kūʻokoʻa, e hoʻolaha ana i ka hoʻokuʻu ʻana o DA a me NE i ka wahi o ka lolo PFC, e hoʻoikaika hou i ka hopena antidepressant. Eia kekahi, hiki i ka agomelatine ke hoʻoikaika i ka hoʻokuʻu ʻana o ka mea neurotrophic i loaʻa i ka lolo i ka PFC a pale i ka hoʻokuʻu ʻana o ka glutamate i hoʻoulu ʻia i ka ʻāpana o ka lolo amygdala.
