5-amino-1-methylquinolinium iodide CAS No.:42464-96-0 98.0% maemae min. | mea hoʻohui mea hana mea hana
Nā Kūlana Huahana
| inoa huahana | 5-amino-1-methylquinolinium iodide |
| inoa ʻē aʻe | NNMTi5-Amino-1-mq iodide 5-amino-1-methylquinolinium iodide 5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE 5-Amino-1-methylquinolin-1-umiodide 1-methylquinolin-1-ium-5-amine;iodide 5-Amino-1-methyl-1-quinolinium Iodide |
| CAS No. | 42464-96-0 |
| ʻAno molekala | C10H11IN2 |
| Kaumaha molekula | 286.11 |
| Maemae | 98% |
| Ka nana aku | Palaka a ʻulaʻula paʻa |
| Hoʻopili | 1kg / ʻeke, 25kg / barela |
| Palapala noi | Mea ʻai meaʻai kumu |
Hoʻolauna huahana
ʻO ka NNMTi kahi enzyme i hoʻohālikelike ʻia i ka wā ʻelemakule o ka ʻiʻo skeletal a pili pū me ka hoʻoponopono ʻana i ka pōʻino o ke ala NAD +, ka hana sirtuin1 dysregulated, a me ka hoʻonui ʻana i ka senescence cell stem cell. Hoʻoikaika ʻo NNMTi i ka ʻokoʻa myoblast in vitro a hoʻomaikaʻi i ka hui ʻana a me ka hoʻoulu hou ʻana o nā ʻiʻo ʻiʻo i loko o nā ʻiole kahiko. ʻO NNMTi kekahi mea paʻa ikaika o ka nicotinamide N-methyltransferase (NNMT) (IC50 = 1.2 μM), koho koho i nā koena kahua paʻa substrate NNMT. Hoʻoikaika ʻo NNMTi i ka ʻokoʻa myoblast in vitro a hoʻomaikaʻi i ka hui ʻana a me ka hoʻoulu hou ʻana o nā ʻiʻo ʻiʻo i loko o nā ʻiole kahiko. I waena o lākou, ua ʻike hou ʻia ka cytosolic enzyme nicotinamide N-methyltransferase (NNMT) e hoʻoponopono i nā pae o nā precursors nicotinamide i koi ʻia no NAD + biosynthesis, a no laila ke kuleana koʻikoʻi i ka hoʻoponopono ʻana i ke ala hoʻopakele NAD + a me ka metabolism cellular.
Hiʻona
(1) Maʻemaʻe kiʻekiʻe: Hiki iā NNMTi ke loaʻa nā huahana maʻemaʻe kiʻekiʻe ma o nā kaʻina hana hoʻomaʻemaʻe. ʻO ka hoʻomaʻemaʻe kiʻekiʻe, ʻoi aku ka maikaʻi o ka bioavailability.
(2) Huli: Hoʻopili pono ʻo NNMTi i ka enzyme NNMT a hiki ke hoʻopaʻa pono i kāna hana, a laila e hoʻopilikia i ke ala metabolic o nicotinamide.
(3) Paʻa: He kūpaʻa maikaʻi ka NNMTi a hiki ke mālama i kāna hana a me ka hopena ma lalo o nā kaiapuni a me nā kūlana mālama.
(4) Nā manaʻo hoʻomohala: Ma muli o nā ʻano ʻano like ʻole o NNMT, ua loaʻa ka manaʻo nui o kona hoʻomohala ʻana a loaʻa i ka noiʻi ākea a me nā noiʻi noiʻi.
Nā noi
ʻO ka NNMTi kahi mea hoʻopiʻi nicotinamide N-methyltransferase (NNMT) e hāpai ana i ka ʻokoʻa myoblast. Hiki ke hoʻohana ʻia ka NNMTi ma ke ʻano he mea hoʻohui e kōkua i ka hōʻemi ʻana i ke kaumaha a me ka momona a hoʻomaikaʻi i ka momona o ke ake.
