He aha ka N-Boc-O-Benzyl-D-Serine a no ke aha he mea nui ia?

I loko o nā ʻoihana kemika a me nā lāʻau lapaʻau, ʻo N-Boc-O-benzyl-D-serine kahi waiwai amino acid derivative ma muli o kona hoʻohana ʻana i ka synthesis o nā moleke bioactive a me nā lāʻau lapaʻau. Ua hoʻokipa nui ʻia no kāna noi ākea i ka hoʻomohala ʻana. "N-Boc" pili i ka pūʻulu pale tert-butoxycarbonyl (Boc), i hoʻohana pinepine ʻia e pale i ka pūʻulu amino o nā waikawa amino i ka peptide synthesis. "O-Benzyl" 'o ia ho'i, ua ho'opili 'ia kahi hui benzyl i ka hui hydroxyl o ka serine, a laila e ho'onui ai i kona kūpa'a a me ka solubility.

N-Boc-O-benzyl-D-serine Introduction

N-Boc-O-benzyl-D-serine (CAS:47173-80-8), ʻike ʻia e like me ka pauka keʻokeʻo keʻokeʻo keʻokeʻo, ʻo N- Boc-O-Benzyl-D-serine kahi derivative o ka amino acid D-serine. Ma muli o kāna mau waiwai kū hoʻokahi, he hana koʻikoʻi ia i ka synthesis kemika a me ke kemika peptide. Eia ka wehewehe kikoʻī o kāna mau ʻāpana: kahi e pili ai ʻo N-Boc i ka pūʻulu pale tert-butoxycarbonyl (Boc).

Hoʻohana ʻia nā pūʻulu pale i ka synthesis organik no ka pale ʻana i nā pūʻulu hana no ka manawa pōkole, e ʻae i nā hopena koho me ka ʻole o ke keakea ʻana mai nā wahi pane ʻē aʻe. Hōʻike ka O-benzyl e pili ana ka hui benzyl i ka oxygen o ka hui hydroxyl o serine. ʻO Benzyl kahi mea hoʻohui ʻala maʻamau i hiki ke hoʻopili i ka solubility a me ka hoʻoulu ʻana o nā pūhui. ʻO D-serine kekahi o nā enantiomers ʻelua o ka serine a no ka ʻohana methionine. ʻO Serine kahi waikawa amino koʻikoʻi no ka biosynthesis, ka hana ʻana o ka ikehu a me ka hana ʻana o nā mea hoʻemi intracellular. He mea koʻikoʻi kēia mau kaʻina no ka ulu ʻana a me ka hoʻonui ʻana o nā maʻi kanesa.

N-Boc-O-benzyl-D-serine hana hoʻomaka

1. Hiki i ka D-serine ke hōʻemi i nā hōʻailona o ka emi ʻana o ka cognitive.

ʻIke ʻia ka hōʻailona Glutaminergic e hoʻonui i ka hoʻomanaʻo hoʻomanaʻo ʻana no ka mea ʻo ka hoʻāla ʻana o nā mea loaʻa NMDA ke kumu o ka komo ʻana o ka calcium a me ka hoʻoneʻe ʻana o ka calmodulin-dependent kinase (CaMK) a me CREB-binding proteins, e hana ana i ka hoʻoulu ʻana i ka potentiation lōʻihi (LTP), kahi kumu o ka ʻike ʻia me ka hoʻomanaʻo, a me ka hopena i ka piʻi ʻana o ka hōʻailona NMDA (ʻoi loa ma o ka subunit NR2B) e hoʻonui ai i ka hoʻomanaʻo a me ka LTP. ʻO kēia hoʻi ka mīkini hoʻonui hoʻomanaʻo i ʻike ʻia me ka magnesium L-threonate. No ka mea hiki i ka D-serine ke hoʻoikaika i ka hōʻailona ma o NMDA receptors, i hui pū ʻia me ka hana o D-serine i kēia kaʻina hana a me ka ʻike ʻike ʻia o nā cell hippocampal i ka D-serine stimulation, ua manaʻo ʻia ʻo ka supplementing D-serine hiki ke hoʻoikaika i ka hoʻomanaʻo a me ke aʻo ʻana.

2.Ua ʻike ʻia ka noiʻi ʻo ka lilo ʻana o ka protein Menin i loko o ka hypothalamus he mea koʻikoʻi e alakaʻi i ka ʻelemakule, a me ka hoʻohui ʻana i ka D-serine hiki ke hoʻomaikaʻi i ka naʻau impairment i nā ʻiole ʻelemakule.

Ua ʻike ʻia nā haʻawina he hana koʻikoʻi ka hypothalamus i ka hōʻino ʻana i ka naʻau ma muli o ka ʻelemakule. I ka wā o ka wā kahiko, e emi mālie ana ka protein Menin i loko o ka hypothalamus (i kapa ʻia ʻo Menin) me ke kaʻina hana ʻelemakule, e pili ana i ka synthesis o D-serine, e hoʻolōʻihi hou i ka hana ʻelemakule a me ka cognitive dysfunction. Eia kekahi, hiki i ka D-serine supplementation ke hoʻomaikaʻi maikaʻi i ka phenotype kahiko a hoʻohaʻahaʻa i ka hōʻino cognitive i nā ʻiole kahiko.

Ua hōʻike ʻia nā hopena o ke aʻo ʻana ma hope o ka hoʻonui ʻana i ka D-serine, ua hoʻonui nui ʻia nā pae o D-serine i ka hypothalamus a me ka hippocampus o nā pūʻulu ʻiole ʻekolu i hoʻohālikelike ʻia me nā ʻano ʻiole like ʻole i hoʻohui ʻia me D-serine (p <0.01), a ua hoʻomaikaʻi ʻia ko lākou kūlana cognitive. ʻO ka hoʻomaikaʻi nui (p<0.05), e hōʻike ana i ka hoʻonui ʻana o D-serine he koho lapaʻau no ka hoʻomaikaʻi ʻana i ka ʻehaʻeha pili i ka ʻelemakule.

N-Boc-O-Benzyl-D-Serine vs. Nā Akina Amino ʻē aʻe: He aha ka ʻokoʻa?

1. Nā ʻokoʻa hoʻolālā

ʻO ka ʻokoʻa loa ma waena o N-Boc-O-benzyl-D-serine a me nā waikawa amino ʻē aʻe kona ʻano. ʻOiai he iwi kuamoʻo maʻalahi nā amino acids me nā pūʻulu amino, nā hui carboxyl a me nā kaulahao ʻaoʻao, ʻo N-Boc-O-benzyl-D-serine nā hui hana hou e hoʻololi i kāna mau waiwai.

No ka laʻana, hāʻawi ka hui Boc i ka pale i ka wā o ka peptide synthesis, e ʻae ana i nā hopena paʻakikī e hana ʻia me ka ʻole o nā ʻaoʻao i makemake ʻole ʻia. Hoʻonui nā hui Benzyl i ka pilina hydrophobic, a laila e hoʻopili ai i ka pelu a me ka paʻa o nā peptides a me nā protein.

2. Nā hiʻohiʻona hana

Hōʻike ʻo N-Boc-O-Benzyl-D-Serine i nā waiwai hana kū hoʻokahi i hoʻohālikelike ʻia me nā waikawa amino ʻē aʻe. Hiki i kāna hoʻonohonoho D ke hana like ʻole me nā ʻōnaehana olaola i hoʻohālikelike ʻia i ka hoʻonohonoho L maʻamau i loaʻa i ka hapa nui o nā protein. Hiki i kēia ke alakaʻi i nā loli i ka hana olaola, e lilo ia i mea hana waiwai i ka hoʻolālā lāʻau a me ka hoʻomohala ʻana.

ʻO ka ʻokoʻa, ʻoi aku ka maʻalahi, ʻoi aku ka maʻamau o nā amino acids e like me glycine a i ʻole alanine ʻaʻole like ka pae o ka paʻakikī a kikoʻī paha i kā lākou pilina. Hoʻohana nui kēia i ka N-Boc-O-Benzyl-D-Serine i nā haʻawina o ka neuropharmacology a me ka launa pū ʻana.

3. No ka noiʻi a me ka lāʻau lapaʻau

Ua hoʻokipa ʻo N-Boc-O-Benzyl-D-Serine i ka nānā ʻana i nā ʻano ʻano like ʻole, ʻoi aku ka nui o ka lāʻau kemika a me ka neurobiology. ʻO kona hiki ke hoʻololi i ka hana receptor NMDA e lilo ia i lāʻau moho no ke aʻo ʻana i nā maʻi neurological e like me ka schizophrenia a me ka maʻi o Alzheimer. Ke ʻimi nei nā mea noiʻi i kona hiki ke lilo i mea lapaʻau e hoʻomaikaʻi i ka hana cognitive a hoʻēmi paha i nā kaʻina neurodegenerative.

ʻO ka ʻokoʻa, ʻoi aku ka nui o nā amino acids e like me ka leucine a i ʻole valine i aʻo pinepine ʻia no kā lākou kuleana i ka metabolism muscle a me ka synthesis protein. ʻOiai he mea koʻikoʻi lākou no ke olakino āpau a me ka maikaʻi, ʻokoʻa kā lākou noi noi i ka neuropharmacology mai N-Boc-O-Benzyl-D-Serine.

4. Hoʻohui a me ka Paʻa

ʻO ka synthesis o N-Boc-O-benzyl-D-serine e pili ana i nā hopena kemika paʻakikī ma mua o nā waikawa amino maʻamau. ʻO ka hoʻokomo ʻana i nā pūʻulu pale a me ka pono o nā kūlana hoʻohālikelike kikoʻī hiki ke hoʻoikaika i kā lākou synthesis. Eia naʻe, hoʻonui kēia mau hoʻololi i kona kūpaʻa, kūpono ia no nā ʻano hoʻokolohua like ʻole.

ʻO ka ʻokoʻa, loaʻa maʻalahi nā waikawa amino maʻamau a maʻalahi hoʻi e synthesize, akā ʻaʻole lākou e hāʻawi i ka pae like o ka paʻa a i ʻole ka kikoʻī i koi ʻia no nā noi noiʻi holomua.

D-Ke ola maoli o N-Boc-O-Benzyl-D-Serine

Hoʻokani ʻo Serine i nā hana physiological koʻikoʻi i loko o ke kino o ke kanaka, ʻoi aku ka hoʻoponopono a me ka pale ʻana o ka ʻōnaehana nerve. ʻO N-Boc-O-benzyl-D-serine ma ke ʻano he serine derivative he papa koʻikoʻi o nā molekole bioactive i hoʻohana pinepine ʻia i ka peptide synthesis a me nā noi kemika organik, ʻoi aku ka nui o ka hoʻomohala ʻana i nā lāʻau lapaʻau a me nā pūhui bioactive. Hiki ke hoʻoneʻe ʻia ka hui pale ma lalo o nā kūlana kikoʻī no ka loaʻa ʻana o nā waikawa amino manuahi a i ʻole nā ​​​​derivatives ʻē aʻe no ka noiʻi hou a i ʻole ka noi. Hoʻohana nui ʻia i ka noiʻi lapaʻau a me ke olaola.

1. ʻO ka hoʻohui kemika a me ka kemika peptide

Hoʻohana ʻia ʻo N-Boc-O-benzyl-D-serine ma ke ʻano he hale kūkulu hale i ka synthesis chemical o nā pūhui like ʻole a he mea nui hoʻi i ka peptide chemistry. ʻO kona hoʻohana ʻana ma kēia kahua ma muli o kona hiki ke hoʻohui ʻia i loko o nā hale molekala nui, e kōkua ana i ka hoʻomohala ʻana i nā lāʻau hou a me nā moleke bioactive.

2. ʻoihana lāʻau lapaʻau

Ua hoʻohana ʻia ʻo N-Boc-O-benzyl-D-serine ma ke ʻano he precursor no ka hoʻomākaukau ʻana i nā naphthodiazolidinones i pani ʻia. Ke hana nei kēia mau pūhui e like me ka protein tyrosine phosphatase degraders a loaʻa iā ia nā noi therapeutic kūpono i ka mālama ʻana i ka maʻi kanesa a me nā maʻi metabolic. ʻO ka hoʻohaʻahaʻa ʻana i kēia mau phosphatases e kōkua i ka hoʻoponopono ʻana i nā ala hōʻailona kelepona, a laila hāʻawi i kahi ala lapaʻau e hakakā ai i kēia mau maʻi.

3. Ka noiʻi a me ka hoʻomohala ʻana

I ka noiʻi a me ka hoʻomohala ʻana, hoʻohana ʻia ʻo N-Boc-O-benzyl-D-serine e synthesize i nā molekala hou me ka hana olaola. ʻO kāna hana kūikawā e hiki ai i nā ʻepekema ke ʻimi i kāna mau waiwai a me nā noi e hana i nā lāʻau lapaʻau hou a me nā lāʻau lapaʻau no nā ʻano maʻi olakino.

Ma hea e kūʻai ai i ka N-Boc-O-benzyl-D-serine?

Ma keʻano he mea hana i ka pauka N-Boc-O-benzyl-D-serine, ua lanakilaʻo Suzhou Myland i ka hilinaʻi o nā mea kūʻai he nui me kāna mau huahana maʻemaʻe kiʻekiʻe a me ka mana koʻikoʻi. Ua paʻa ka hui i ka hāʻawi ʻana i nā mea kūʻai aku i nā mea waiwai kiʻekiʻe a kōkua iā lākou e kūleʻa i kā lākou ʻoihana.

1. ʻO ka maikaʻi o ka huahana hilinaʻi

ʻO ka pauka N-Boc-O-benzyl-D-serine o Suzhou Myland e hana i nā hoʻokolohua he nui e hōʻoia i kona maʻemaʻe a me ka maikaʻi e kūpono i nā kūlana ʻoihana. Loaʻa i ka hui kahi pūʻulu hoʻomaʻamaʻa maikaʻi maikaʻi e hana i ka nānā ʻana i nā huahana maʻamau e hōʻoia i ka maikaʻi paʻa o kēlā me kēia pūʻulu o nā huahana.

2. Hiki ke lako lako

Inā he pūʻulu liʻiliʻi a i ʻole he kauoha nui, hiki iā Suzhou Mailun Biotechnology ke pane maʻalahi e hōʻoia i ka hoʻokō ʻana i nā pono o ka mea kūʻai aku. Ua hoʻokumu ka hui i kahi ʻōnaehana logistic piha e hāʻawi koke i nā huahana i nā mea kūʻai aku.

3. Kākoʻo ʻenehana ʻoihana

ʻO ka hui R&D o Suzhou Myland he nui o nā loea ʻoihana a hiki iā ia ke hāʻawi i nā mea kūʻai aku i ke kūkākūkā ʻenehana loea a me ke kākoʻo e kōkua i nā mea kūʻai aku e hoʻomaopopo a hoʻopili iā N-Boc-O-benzyl-D-serine.

4. Kumu kūʻai hoʻokūkū

Ma ke kumu o ka hōʻoia ʻana i ka maikaʻi o ka huahana, hāʻawi ʻo Suzhou Myland i nā kumukūʻai hoʻokūkū e kōkua i nā mea kūʻai aku e hōʻemi i nā kumukūʻai kūʻai a hoʻomaikaʻi i ka hoʻokūkū mākeke.

ʻO ke koho ʻana i ka mea hoʻolako N-Boc-O-benzyl-D-serine kūpono ke kī i ka hōʻoia ʻana i ka maikaʻi o ka huahana a me ka palekana. Ua lilo ʻo Suzhou Myland i koho hilinaʻi ma ka ʻoihana me kāna mau huahana maʻemaʻe kiʻekiʻe, ka mana koʻikoʻi a me nā lawelawe ʻoihana. Inā he hui lāʻau lapaʻau ʻoe a i ʻole kahi hale noiʻi ʻepekema, hiki iā Suzhou Myland ke hāʻawi iā ʻoe i ka pauka N-Boc-O-benzyl-D-serine kiʻekiʻe e kōkua i kāu noiʻi a me ka hoʻomohala ʻana. No ka ʻike hou aku, e ʻoluʻolu e kipa i ka pūnaewele mana o Suzhou Myland.