ʻO Urolithin A (UA) he mea hoʻohui i hana ʻia e ka metabolism o nā mea kanu ʻōpū i nā meaʻai momona i nā ellagitannins (e like me ka pomegranate, raspberries, etc.). Manaʻo ʻia he anti-inflammatory, anti-aging, antioxidant, induction of mitophagy a me nā hopena ʻē aʻe, a hiki ke hele i ka pale koko-lolo. Ua hōʻoia ʻia nā haʻawina he nui e hiki i ka urolithin A ke hoʻopaneʻe i ka ʻelemakule, a ua hōʻike pū nā haʻawina lapaʻau i nā hopena maikaʻi.
ʻAʻole loaʻa nā Urolithin i ka meaʻai; akā naʻe, ʻo kā lākou polyphenols mua. Nui nā polyphenols i nā huaʻai a me nā mea kanu. Ke ʻai ʻia, hoʻopili pololei ʻia kekahi mau polyphenols e ka ʻōpū liʻiliʻi, a hoʻohaʻahaʻa ʻia kekahi e ka bacteria digestive i loko o nā pūhui ʻē aʻe, ʻo kekahi o ia mau mea e pono ai. No ka laʻana, hoʻohiolo kekahi mau ʻano bacteria ʻōpū i ka ellagic acid a me nā ellagitannins i urolithins, hiki ke hoʻomaikaʻi i ke olakino kanaka.
ʻO Urolithin Ahe ellagitannin (ET) metabolite o ka pua o ka ʻōpū. E like me ka metabolic precursor o Uro-A, nā kumu meaʻai nui o ET he pomegerane, strawberries, raspberries, walnuts a me ka waina ʻulaʻula. ʻO ka UA kahi huahana o nā ET i hoʻololi ʻia e nā microorganisms ʻōpū.
ʻAʻole ʻo Urolithin-A i loko o ke ʻano kūlohelohe, akā hana ʻia e nā ʻano hoʻololi o ET e ka flora intestinal. ʻO ka UA kahi huahana o nā ET i hoʻololi ʻia e nā microorganisms ʻōpū. ʻO nā meaʻai momona i ka ET e hele i loko o ka ʻōpū a me ka ʻōpū liʻiliʻi i loko o ke kino o ke kanaka, a hoʻololi ʻia i loko o ka Uro-A i loko o ke kolonā. Hiki ke ʻike ʻia kahi helu liʻiliʻi o Uro-A ma ka ʻōpū liʻiliʻi haʻahaʻa.
Ma ke ʻano he pūhui polyphenolic maoli, ua ʻike nui ʻia nā ET ma muli o kā lākou mau hana olaola e like me antioxidant, anti-inflammatory, anti-allergic and anti-viral. Ma waho aʻe o ka loaʻa ʻana mai o nā meaʻai e like me nā pomegerane, strawberries, walnuts, raspberries, a me nā ʻalemona, loaʻa pū nā ETs i nā lāʻau lapaʻau Kina kahiko e like me ka gallnuts, pomegranate peels, Uncaria, Sanguisorba, Phyllanthus emblica, a me agrimony. ʻO ka hui hydroxyl i loko o ka molecular structure o ETs he polar, ʻaʻole kūpono i ka absorption o ka paia o ka ʻōpū, a haʻahaʻa loa kona bioavailability.
Ua ʻike ʻia nā haʻawina he nui ma hope o ka ʻai ʻia ʻana o nā ET e ke kino o ke kanaka, ua hoʻololi ʻia lākou e nā pua ʻōpū i loko o ke kolonā a hoʻololi ʻia i urolithin ma mua o ka lawe ʻia ʻana. Hoʻopili ʻia nā ETs i loko o ka ʻakika ellagic (EA) ma ka ʻāpana ʻōpū o luna, a hele ʻia ʻo EA ma nā ʻōpū. Hoʻomaka hou ka pua bacteria a nalowale ke apo lactone a hoʻomau i nā hopena dehydroxylation e hoʻoulu ai i ka urolithin. Aia nā hōʻike e hiki i ka urolithin ke kumu waiwai no nā hopena olaola o ET i ke kino.
ʻO Mitochondria nā hale mana o kā mākou pūnaewele, kuleana no ka hana ʻana i ka ikehu a mālama i nā hana kelepona. I ko mākou mau makahiki, ua emi ka hana mitochondrial, e alakaʻi ana i nā pilikia olakino. Ua ʻike ʻia ka noiʻi hiki i ka urolithin A ke hōʻano hou a hoʻonui i ka hana mitochondrial, hiki ke hoʻolōʻihi i ke kaʻina hana ʻelemakule a hoʻoikaika i ke olakino holoʻokoʻa a me ka ikaika.
Hiki ke loaʻa mai ka Urolithin A mai ka meaʻai e like me ka mea maka o UA, a ʻaʻole ia he manaʻo ʻo ka ʻai ʻana i nā meaʻai i loaʻa i nā precursors UA e alakaʻi i ka synthesis o ka urolithin A. ʻO ia hoʻi ma muli o ke ʻano o ka flora intestinal.
ʻO Urolithin A he metabolite i hana ʻia e ka ʻōpū microbiota ma hope o ka ʻai ʻana i kekahi mau meaʻai, e like me nā pomegerane, nā hua, a me nā nati. Ua loaʻa i kēia pūhui ka manaʻo no kona hiki ke hoʻāla i ka mitophagy, kahi kaʻina e hoʻoneʻe ai i ka mitochondria pōʻino mai nā pūnaewele, a laila e hāpai ana i ka hoʻōla hou ʻana o ka cell a me ke olakino holoʻokoʻa. ʻO ka manawa i kapa ʻia ʻo ka mana o ke kelepona, he kuleana koʻikoʻi ka mitochondria i ka hana ikehu a me ka hana cellular. I ko mākou mau makahiki, emi iho ka pono mitochondrial, e alakaʻi ana i nā ʻano pilikia olakino pili makahiki. Ua hōʻike ʻia ʻo Urolithin A e kākoʻo i ke olakino mitochondrial a me ka hana, hiki ke hoʻēmi i nā hopena o ka ʻelemakule ma ka hana ʻana o ka ikehu cellular a me ke ola holoʻokoʻa.
Kūʻē i ka ʻelemakule
Ke manaʻoʻiʻo nei ka manaʻo radical manuahi o ka ʻelemakule ʻo nā ʻano oxygen reactive i hana ʻia i ka metabolism mitochondrial ke kumu o ke kaumaha oxidative i ke kino a alakaʻi i ka ʻelemakule, a he kuleana nui ka mitophagy i ka mālama ʻana i ke olakino mitochondrial a me ka pono. Ua hōʻike ʻia e hiki i ka UA ke hoʻoponopono i ka mitophagy a no laila e hōʻike i ka hiki ke hoʻopaneʻe i ka ʻelemakule. Ua ʻike nā haʻawina e hoʻēmi ana ʻo UA i ka mitochondrial dysfunction a hoʻonui i ke ola o Caenorhabditis elegans ma o ka hoʻoulu ʻana i ka mitophagy; i nā rodents, hiki iā UA ke hoʻohuli i ka emi ʻana o ka hana ʻiʻo pili makahiki, e hōʻike ana e hoʻomaikaʻi ʻo UA i ka maikaʻi o ka ʻiʻo ma o ka hoʻonui ʻana i ka hana mitochondrial. A e hooloihi aku i ke ola o ke kino.
Hoʻoulu ʻo Urolithin A i ka mitophagy
ʻO kekahi o kēia ka mitophagy, e pili ana i ka wehe ʻana a me ka hana hou ʻana o ka mitochondria kahiko a i hoʻolei ʻia.
Me ka makahiki a me kekahi mau ma'i e pili ana i ka makahiki, e emi ana ka mitophagy a stagnate paha, a e emi malie ana ka hana o ke kino. Ua ʻike ʻia ka pale ʻana o ka urolithin A i ka nalowale ʻana o ka ʻiʻo, a ʻo ka noiʻi mua ʻana e pili ana i ka mitochondria, ʻoi aku ka mitophagy. (E pili ana ka Mitophagy i ka wehe koho ʻana o ka mitochondria i poino ma o autophagosomes) Hiki iā UA ke hoʻoikaika i ka mitophagy ma o nā ala he nui, e like me ka hoʻoulu ʻana i nā enzymes e hoʻoikaika ai i ka mitophagy, a i ʻole ka hoʻoponopono ʻana i ke ala mitophagy, a me ka hoʻoikaika ʻana i nā autophagosome. Hoʻokumu etc.
Ka hopena antioxidant
I kēia manawa, nui nā noiʻi i hana ʻia e pili ana i ka hopena antioxidant o urolithin. Ma waena o nā metabolites urolithin āpau, ʻo Uro-A ka hana antioxidant ikaika loa. Ua ho'āʻoʻia ka oxygen free radical absorption o ka plasma o nā mea manawaleʻa olakino a uaʻikeʻia ua hoʻonuiʻia ka mana antioxidant e 32% ma hope o ka 0.5 h o ka inuʻana i ka wai pomegerane, akāʻo ka hanaʻAʻohe loli nui i nā pae oxygen, akā i loko ʻO nā hoʻokolohua vitro ma nā pūnaewele Neuro-2a, ua ʻike ʻia ʻo Uro-A e hōʻemi i ke kiʻekiʻe o nā ʻano oxygen reactive i nā cell. Hiki i nā mea hoʻohui koʻikoʻi koʻikoʻi ka metabolite ʻo Uro-A ke hōʻemi i nā pae koʻikoʻi oxidative o ka poʻe maʻi, ma laila e hoʻomaikaʻi ai i ke ʻano o ka poʻe maʻi, luhi a me ka insomnia. Hōʻike kēia mau hopena he mau hopena antioxidant ikaika ʻo Uro-A.
Ka hopena anti-inflammatory
ʻO kahi hopena maʻamau i waena o nā hiʻohiʻona lapaʻau āpau o UA ka attenuation o ka pane inflammatory.
Ua ʻike mua ʻia kēia hopena i nā ʻiole me nā hoʻokolohua enteritis, kahi i hoʻemi ʻia ai nā pae mRNA a me ka protein o ka marker inflammatory cyclooxygenase 2. Me ka noiʻi hou aʻe, ua ʻike ʻia ʻo nā mea hōʻailona inflammatory ʻē aʻe, e like me nā mea pro-inflammatory a me nā kumu necrosis tumor, ua hoʻemi ʻia i nā pae like ʻole. He nui ka hopena anti-inflammatory o UA. ʻO ka mea mua, aia i loko o ka nui o ka ʻōpū, no laila ʻo ka hapa nui o ka mea hana ʻo ia ka maʻi inflammatory bowel. ʻO ka lua, ʻaʻole pale wale ʻo UA i ka ʻāʻī o ka ʻōpū no ka mea e hōʻemi ana ia i nā pae serum holoʻokoʻa o nā mea inflammatory. Ma ka manaʻo, hiki iā UA ke hana i nā maʻi i hoʻokumu ʻia e ka mumū.
Nui nā mea, e like me ka arthritis, intervertebral disc degeneration a me nā maʻi hui ʻē aʻe i maʻamau i ka poʻe ʻelemakule; Eia kekahi, ʻo nā aʻalolo e hoʻopōʻino ana i ka mumū ke kumu o nā maʻi neurodegenerative he nui. No laila, ke hana ʻo UA i ka hopena anti-inflammatory i ka lolo, hiki iā ia ke hoʻomaikaʻi i nā maʻi neurodegenerative he nui, me ka maʻi Alzheimer (AD), ka hoʻomanaʻo ʻana, a me ka hahau.
ʻO Urolithin A a me nā maʻi cardiovascular a me ka cerebrovascular
Ua hōʻike ʻia ʻo UA he mau hopena anti-inflammatory a antioxidant ikaika, a ua hōʻoia nā haʻawina kūpono e hiki i ka UA ke pāʻani i ka hana pono i ka CVD. Ua loaʻa i nā haʻawina vivo hiki i ka UA ke hoʻemi i ka pane mua ʻana o ka myocardial tissue i ka hyperglycemia a hoʻomaikaʻi i ka myocardial microenvironment, e paipai ana i ka hoʻihoʻi ʻana o ka cardiomyocyte contractility a me ka calcium dynamics, e hōʻike ana e hiki ke hoʻohana ʻia ʻo UA ma ke ʻano he lāʻau kōkua no ka mālama ʻana i ka cardiomyopathy diabetic a pale aku. ia. pilikia. Hiki i ka UA ke hoʻomaikaʻi i ka hana mitochondrial a me ka hana ʻiʻo ma o ka hoʻoulu ʻana i ka mitophagy. ʻO ka mitochondria naʻau nā ʻāpana koʻikoʻi e hana i ka ATP waiwai nui. ʻO ka mitochondrial dysfunction ke kumu o ka pau ʻole o ka naʻau. Ke manaʻo ʻia nei ka dysfunction Mitochondrial i kēia manawa he hopena therapeutic kūpono. No laila, ua lilo ʻo UA i moho hou no ka mālama ʻana i ka CVD.
ʻO Urolithin A a me ka ʻōnaehana nerve
ʻO ka neuroinflammation kahi hana koʻikoʻi i ka hanana a me ka ulu ʻana o nā maʻi neurodegenerative. ʻO ka apoptosis i hoʻokumu ʻia e ke koʻikoʻi oxidative a me ka hōʻuluʻulu protein abnormal e hoʻoulu pinepine i ka neuroinflammation, a ʻo nā cytokine pro-inflammatory i hoʻokuʻu ʻia e neuroinflammation a laila pili i ka neurodegeneration. Ua ʻike nā haʻawina ʻo UA e hoʻopili ana i ka hana anti-inflammatory ma o ka hoʻoulu ʻana i ka autophagy a me ka hoʻoulu ʻana i ka mea hoʻoponopono hōʻailona leo 1 (SIRT-1) deacetylation mechanical, inhibiting neuroinflammation a me neurotoxicity, a me ka pale ʻana i ka neurodegeneration, e hōʻike ana he ʻoihana Neuroprotective kūpono ʻo UA. Ma ka manawa like, ua ʻike kekahi mau haʻawina e hiki i ka UA ke hoʻokō i nā hopena neuroprotective ma o ka hoʻopaʻa pono ʻana i nā radical manuahi a me ka pale ʻana i nā oxidases. Ahsan et al. Ua ʻike ʻia ʻo UA ke kāohi nei i ka endoplasmic reticulum stress ma ka hoʻoulu ʻana i ka autophagy, a laila e hoʻohaʻahaʻa i ka make neuronal ischemic, a hiki ke mālama i ka cerebral ischemic stroke.
Ua ʻike ka haʻawina e hiki i ka wai pomegerane ke mālama i nā ʻiole PD i hoʻokomo ʻia i ka rotenone, a ʻo ka hopena neuroprotective o ka wai pomegerane ka mea nui ma o UA. Ua hōʻike nā haʻawina e hana ana ka wai pomegranate i kahi neuroprotective ma ka hoʻonui ʻana i ka hana mitochondrial aldehyde dehydrogenase, mālama i ke kiʻekiʻe o ka protein anti-apoptotic Bcl-xL, e hōʻemi ana i ka α-synuclein aggregation a me ka pōʻino oxidative, a pili i ka hana neuronal a me ke kūpaʻa. ʻO nā pūhui Urolithin nā metabolites a me nā ʻāpana hopena o nā ellagitannins i loko o ke kino a loaʻa nā hana olaola e like me ka anti-inflammation, anti-oxidative stress, a me ka anti-apoptosis. Hiki i ka Urolithin ke hoʻoikaika i ka hana neuroprotective ma o ka pale koko-lolo a he mole liʻiliʻi liʻiliʻi hiki ke hoʻopilikia i ka neurodegeneration.
Kōkua e hoʻemi i ke kaumaha
ʻAʻole hiki i ka Urolithin A ke pale wale i nā ʻiʻo, akā ua ʻike ka noiʻi hou loa hiki i ka urolithin A ke hoʻopilikia maoli i ka metabolism lipid cellular a me ka lipogenesis. Hiki iā ia ke hōʻemi i ka hōʻiliʻili ʻana o ka triglyceride a me ka oxidation fatty acid, a me ka hōʻike ʻana o nā genes pili i ka lipogenesis, ʻoiai e pale ana i ka hōʻiliʻili momona ʻai.
Ua lohe paha ʻoe i ka momona brown, he ʻano momona ʻokoʻa. ʻAʻole wale ʻaʻole ia e momona iā ʻoe, hiki ke puhi i ka momona. No laila, ʻoi aku ka nui o ka momona ʻeleʻele, ʻoi aku ka maikaʻi no ka pohō kaumaha.
Pomegerane
ʻIke ʻia nā pomegerane no ko lākou kiʻekiʻe o ka ellagic acid, hiki ke hoʻololi ʻia i urolithin A e nā microbes intestinal. ʻO ka inu ʻana i ka wai pomegerane a i ʻole ka hoʻohui ʻana i nā hua pomegerane i kāu ʻai e hāʻawi i kahi kumu maoli ourolithin A, e kākoʻo ana i ka hoʻōla hou ʻana o nā cell a me ke olakino holoʻokoʻa.
Beri
ʻO kekahi mau huaʻai, e like me nā strawberries, raspberries, a me nā ʻeleʻele, loaʻa i ka ellagic acid a he kumu kūpono ia o ka urolithin A. ʻO ka hoʻohui ʻana i kēia mau hua ʻono i kāu meaʻai ʻaʻole e hoʻohui wale i ka ʻono akā hāʻawi pū kekahi i nā pōmaikaʻi olakino a lōʻihi o ka urolithin A.
Nut
ʻO kekahi mau nati, e like me ka walnuts a me ka pecans, loaʻa i ka ellagic acid, hiki ke hoʻololi ʻia i loko o ka ʻōpū i ka urolithin A. ʻO ka hoʻohui ʻana i kahi lima o nā nati i kāu ʻai ʻai i kēlā me kēia lā e hiki ke kōkua i ka hoʻonui ʻana i ka urolithin A intake a kākoʻo i ka hoʻōla hou ʻana o nā cell.
ʻAno microbiota
Ma waho aʻe o nā kumu meaʻai, ʻo ke ʻano o ka microbiota intestinal kekahi kuleana koʻikoʻi i ka hana ʻana o ka urolithin A. ʻO ka ʻai ʻana i nā meaʻai waiwai prebiotic, e like me nā aniani, ke kāleka, a me ka maiʻa, hiki ke kākoʻo i ka ulu ʻana o nā hua bacteria maikaʻi. Hoʻonui i ka hoʻololi ʻana o ka waikawa ellagic i urolithin A.
Urolithin A mea hoʻohui
ʻO kekahi o nā kumu kaulana loa o ka urolithin A he pomegerane. I ka wā o ka ʻai ʻana, hoʻohuli ka bacteria o ka ʻōpū i nā molekele ellagitannin i loko o nā pomegerane i urolithin A.
Akā ʻokoʻa ka microbiome o kā mākou ʻōpū e like me mākou, a ʻokoʻa me ka meaʻai, ka makahiki a me nā genetics, no laila, hoʻopuka nā kānaka ʻē aʻe i ka urolithin ma nā kumukūʻai like ʻole. ʻO ka poʻe me ka maʻi bacteria, ʻoi aku ka poʻe mai ka ʻohana Clostridia a me Ruminococcaceae e noho ana i loko o ka ʻōpū, ʻaʻole hiki ke hana i kekahi urolithin A!
ʻO ka poʻe hiki ke hana i ka urolithin A ʻaʻole i lawa ka nui. ʻO ka ʻoiaʻiʻo, ʻo 1/3 wale nō ka poʻe e hana i ka urolithin A.
ʻOiai ke olakino a me ka ʻono, ʻaʻole lawa ka ʻai ʻana i nā meaʻai nui e like me nā pomegerane no kou ʻōpū e hoʻohua ai i ka urolithin A. ʻO Urolithin A supplementation he mea hana kūpono a hiki ke hoʻomaikaʻi i ke olakino a me ka lōʻihi o ka poʻe ʻelemakule.
Loaʻa ʻia ʻo Urolithin A mai ka ellagic acid, kahi hui kūlohelohe e pili ana me ka hoʻomaikaʻi ʻana i ka hana mitochondrial a me ka rejuvenation cellular holoʻokoʻa. Eia nō naʻe, ʻoiai he nui ka poʻe e pōmaikaʻi mai nā mea hoʻohui urolithin A, he mea nui e hoʻomaopopo pono i kekahi mau pūʻulu e hoʻomaʻamaʻa makaʻala a ʻalo paha i ka lawe ʻana i ka urolithin A.
Nā wāhine hāpai a me nā wāhine hānai
Pono nā wahine hāpai a me nā wahine hānai e makaʻala i ka wā e noʻonoʻo ai i ka urolithin A supplementation. ʻOiai he liʻiliʻi ka noiʻi ʻana e pili ana i ka hopena o ka urolithin A i kēia heluna kanaka, ʻōlelo pinepine ʻia e pale aku nā wahine hāpai a me nā wahine hānai i ka lawe ʻana i nā mea hoʻohui hou a i ʻole nā lāʻau lapaʻau ke ʻole i ʻōlelo ʻia e ke kauka mālama ola. ʻAʻole ʻike ʻia nā hopena kūpono o ka urolithin A i ka ulu ʻana o ka fetal a me nā pēpē i hānai ʻia, no laila ʻoi aku ka maikaʻi e hoʻomau me ka akahele.
ʻO ka poʻe me nā maʻi allergies i ʻike ʻia
E like me kekahi mea hoʻohui, ʻo ka poʻe me ka maʻi allergies i ʻike ʻia i ka urolithin A a i ʻole nā hui pili e pono e pale i ka hoʻohana. Hiki ke loaʻa nā hopena maʻi mai ka ʻoluʻolu a hiki i ke koʻikoʻi a hiki ke komo i nā hōʻailona e like me ka ʻili, ka hives, ka pehu, a me ka pilikia o ka hanu. He mea nui e nānā pono i nā mea hoʻohui o kēlā me kēia huahana urolithin A a nīnau i kāu mea mālama ola inā maopopo ʻole ʻoe i kahi allergen.
ʻO nā kānaka me nā maʻi lalo
Pono e makaʻala ka poʻe me nā maʻi maʻi lalo, ʻo ia hoʻi nā mea e pili ana i ka hana ʻāʻī a i ʻole ka ate, i ka wā e noʻonoʻo ai i ka urolithin A supplementation. No ka mea, ua hoʻololi ʻia ka urolithin A i loko o ke ake a hoʻokuʻu ʻia e nā puʻupaʻa, hiki i ka poʻe me ka hana hepatic a i ʻole ka hana renal ke piʻi aʻe i ka pilikia no nā hopena ʻino. He mea nui i nā poʻe me nā maʻi maʻi maʻi mua e nīnau i kahi ʻoihana mālama ola ma mua o ka hoʻomaka ʻana i ka urolithin A supplementation.
ʻO nā keiki a me nā ʻōpio
Ma muli o ka liʻiliʻi o ka noiʻi ʻana e pili ana i ka hopena o ka urolithin A i nā keiki a me nā ʻōpio, ʻoi aku ka nui o ka poʻe ma lalo o 18 mau makahiki e pale aku i ka urolithin A supplementation ke ʻole i kuhikuhi ʻia e kahi mea mālama ola. Hiki i nā kino ulu o nā keiki a me nā ʻōpio ke pane ʻokoʻa i ka supplementation, a ʻaʻole ʻike ʻia nā hopena lōʻihi o ka urolithin A i kēia heluna kanaka.
Pilikino lāʻau
Hiki i ka Urolithin A ke launa pū me kekahi mau lāʻau lapaʻau, ʻoi aku ka nui o nā mea i hoʻololi ʻia i loko o ke ake. Pono ka poʻe e lawe i nā lāʻau lapaʻau e nīnau i kekahi kauka mālama ola ma mua o ka hoʻohui ʻana i ka urolithin A i kā lākou ʻano lapaʻau no ka hōʻoia ʻana ʻaʻohe pilina pili e pili ana i ka palekana a i ʻole ka pono o kā lākou mau lāʻau.
1. ʻO nā mea kūʻai kūʻai kumu kūʻai kaulana
ʻO kekahi o nā kumu hilinaʻi loa no ke kūʻai ʻana i ka pauka Urolithin A ma o kahi mea kūʻai kūʻai waiwai kaulana. Kūʻai pinepine kēia mau mea kūʻai aku i nā ʻano meaʻai meaʻai kiʻekiʻe, me ka pauka urolithin A. Ke koho ʻana i kahi mea kūʻai aku, e ʻimi i nā mea e hoʻokumu i ka maikaʻi o ka huahana, ʻike maopopo, a me ka ʻoluʻolu o ka mea kūʻai aku. He mea nui ka heluhelu ʻana i nā loiloi o ka mea kūʻai aku a nānā i ka hoʻāʻo ʻana a me ka hōʻoia ʻana o nā ʻaoʻao ʻekolu e hōʻoia i ka ʻoiaʻiʻo a me ka maʻemaʻe o ka pauka Urolithin A.
2. Hale kūʻai ola kino pūnaewele i hōʻoia ʻia
ʻO nā hale kūʻai ola olakino i hōʻoia ʻia he koho maikaʻi loa no ke kūʻai ʻana i ka pauka Urolithin A. Kūleʻa kēia mau hale kūʻai i nā ʻano huahana olakino kūlohelohe, me ka pauka urolithin A. Ke kūʻai aku nei mai nā hale kūʻai olakino olakino i hōʻoia ʻia, e ʻimi i nā mea e hāʻawi i ka ʻike kikoʻī o ka huahana, me ke kumu o ka pauka Urolithin A a me nā hopena hoʻokolohua ʻekolu. Eia hou, loaʻa i nā hale kūʻai ola olakino kaulana nā ʻelele lawelawe mea kūʻai aku e hiki ke hoʻoponopono i nā nīnau a i ʻole nā manaʻo e pili ana i kā lākou huahana.
3. pololei mai ka mea hana
ʻO kahi koho kūpono ʻē aʻe no ke kūʻai ʻana i ka pauka Urolithin A ʻo ke kūʻai pololei ʻana mai ka mea hana. Hāʻawi ka nui o nā mea hana pauka urolithin A i kā lākou huahana no ke kūʻai aku ma ka pūnaewele ma o kā lākou pūnaewele mana. ʻO ke kūʻai pololei ʻana mai ka mea hana e hōʻoiaʻiʻo i ka ʻoiaʻiʻo a me ka maikaʻi o ka huahana. Eia kekahi, hāʻawi iā ʻoe i ka ʻike kikoʻī e pili ana i ka sourcing, hana a me ka hoʻāʻo ʻana o Urolithin A pauka, e hāʻawi iā ʻoe i ka maluhia o ka noʻonoʻo e pili ana i ka maikaʻi a me ka pono o kāu huahana.
ʻO Suzhou Myland Pharm & Nutrition Inc. kahi mea hana i kākau inoa ʻia e FDA e hāʻawi ana i ka pauka urolithin A kiʻekiʻe a maʻemaʻe.
Ma Suzhou Myland Pharm, ua kūpaʻa mākou i ka hāʻawi ʻana i nā huahana kiʻekiʻe loa i nā kumukūʻai maikaʻi loa. ʻO kā mākou Urolithin A pauka i hoʻāʻo ikaika ʻia no ka maʻemaʻe a me ka ikaika, e hōʻoiaʻiʻo ana e loaʻa iā ʻoe kahi mea hoʻopihapiha kiʻekiʻe hiki iā ʻoe ke hilinaʻi. Inā makemake ʻoe e kākoʻo i ke olakino cellular, hoʻonui i kāu ʻōnaehana pale a hoʻomaikaʻi i ke olakino holoʻokoʻa, ʻo kā mākou Urolithin A pauka ke koho kūpono loa.
Me 30 mau makahiki o ka ʻike a alakaʻi ʻia e ka ʻenehana kiʻekiʻe a me nā hoʻolālā R&D kiʻekiʻe loa, ua hoʻomohala ʻo Suzhou Myland Pharm i kahi ʻano o nā huahana hoʻokūkū a lilo i mea hoʻohui ʻepekema ola hou, synthesis maʻamau a me nā hui lawelawe hana.
Eia kekahi, ʻo Suzhou Myland Pharm kekahi mea hana inoa FDA. ʻO nā kumuwaiwai R&D o ka hui, nā lako hana, a me nā mea hana analytical he mea hou a multifunctional, a hiki ke hana i nā kemika mai ka milligrams a hiki i nā tona i ka unahi, a hoʻokō i nā kūlana ISO 9001 a me nā kikoʻī hana GMP.
4. Makeke Ola
ʻO ka mākeke olakino a maikaʻi kahi kahua pūnaewele e hui pū ai i nā ʻano huahana olakino kūlohelohe mai nā mea kūʻai aku a me nā hōʻailona like ʻole. Hāʻawi pinepine kēia mau mākeke iā Urolithin A pauka mai nā mea hana like ʻole a me nā mea kūʻai aku, hāʻawi iā ʻoe i ka manawa e hoʻohālikelike ai i nā huahana a me nā kumukūʻai. Ke kūʻai aku nei ʻoe i ka mākeke olakino a maikaʻi, e nānā pono i ka helu o ka mea kūʻai aku a me ka manaʻo o ka mea kūʻai aku e hōʻoia i ke kūʻai ʻana mai kahi kumu kaulana a hilinaʻi.
Q: He aha ka urolithin A pauka a pehea e pono ai?
A: Urolithin ʻO ka pauka he hui kūlohelohe i loaʻa mai ka metabolism o nā ellagitannins, loaʻa i nā hua e like me nā pomegerane a me nā hua. Ua hōʻike ʻia he mau pono olakino like ʻole, me ka hoʻolaha ʻana i ke olakino mitochondrial, ka hana ʻiʻo, a me ka rejuvenation cellular holoʻokoʻa.
Q: Pehea e hoʻohana ʻia ai ka pauka urolithin A?
A: Urolithin Hiki ke hoʻopau ʻia kahi pauka ma ke ʻano he meaʻai meaʻai ma ke ʻano o nā capsules a i hoʻohui ʻia i nā meaʻai a me nā mea inu. Ke aʻo ʻia nei hoʻi no kona hoʻohana ʻana i nā huahana mālama ʻili ma muli o kāna mau waiwai anti-kahiko.
Q: He aha nā pōmaikaʻi olakino o ka pauka urolithin A?
A: Hōʻike ka noiʻi e hiki i ka urolithin A pauka ke kōkua i ka hoʻomaikaʻi ʻana i ka hana o ka ʻiʻo, ka hoʻoikaika ʻana i ka ʻelemakule olakino, a me ke kākoʻo ʻana i ke olakino cellular holoʻokoʻa. Ua hoʻopili pū ʻia i nā pono kūpono no ke olakino ʻōpū a me ka hōʻemi ʻana i ka mumū.
Q: Ma hea e kūʻai ʻia ai ka pauka urolithin A?
A: Urolithin Hiki ke loaʻa ka pauka ma nā hale kūʻai meaʻai olakino, nā hale kūʻai pūnaewele, a ma o nā hui hoʻohui meaʻai. He mea nui e hōʻoia i ka huahana mai kahi kumu kaulana a e hahai i nā alakaʻi kuhikuhi i ʻōlelo ʻia.
Hoʻopau: No ka ʻike maʻamau wale nō kēia ʻatikala a ʻaʻole pono e manaʻo ʻia he ʻōlelo aʻoaʻo olakino. Loaʻa mai kekahi o ka ʻike moʻomanaʻo blog mai ka Pūnaewele a ʻaʻole ʻoihana. ʻO kēia pūnaewele wale nō ke kuleana no ka hoʻokaʻawale ʻana, ka hoʻopili ʻana a me ka hoʻoponopono ʻana i nā ʻatikala. ʻO ke kumu o ka hāʻawi ʻana i nā ʻike hou aʻe ʻaʻole ia he manaʻo ʻae ʻoe i kāna mau manaʻo a hōʻoia paha i ka ʻoiaʻiʻo o kāna ʻike. E nīnau mau i kahi ʻoihana mālama ola ma mua o ka hoʻohana ʻana i nā mea hoʻohui a i ʻole ka hoʻololi ʻana i kāu ʻano mālama ola kino.
Ka manawa hoʻouna: ʻAukake-30-2024
