ʻO Urolithin A nā hui kūlohelohe he mau hui metabolite i hana ʻia e nā bacteria ʻōpū e hoʻololi i nā ellagitannins e hoʻomaikaʻi i ke olakino ma ka pae cellular. Ua loaʻa iā Urolithin B ka manaʻo o nā mea noiʻi no kona hiki ke hoʻomaikaʻi i ke olakino ʻōpū a hōʻemi i ka mumū. He mau waiwai pili ko Urolithin A a me urolithin B, akā he mau ʻokoʻa ko lākou. He aha nā ʻokoʻa kikoʻī āu, e ʻike kākou!
I nā makahiki i hala iho nei, ua aʻo nā kānaka ʻepekema i nā pono olakino o ka urolithin, kahi hui kūlohelohe he hui metabolite i hana ʻia e ka hoʻololi ʻana o nā ellagitannins e nā bacteria ʻōpū. ʻO kona mau mea mua he ellagic acid a me ellagitannins, i loaʻa maoli i loko o kekahi mau kumu meaʻai e like me ka pomegranate, guava, tī, pecans, nati, a me nā hua e like me nā strawberries, nā raspberries ʻeleʻele, a me nā blackberries. Eia kekahi, ʻo ka urolithin A, he polyphenol kūlohelohe, he mea hoihoi ia ma ke ʻano he antioxidant ikaika a me ka mea anti-inflammatory me nā pono olakino maikaʻi.
Snā haʻawina e noiʻi ana i kaUa hōʻike ʻia nā hopena o ka UA ma nā hana cellular a me nā ala olaola he nui nā ʻano hana. Ua ʻike pū ʻia nā haʻawina e hoʻoulu ana ka UA i ka mitochondrial autophagy, kahi hana e wehe ai i ka mitochondria i hōʻino ʻia mai ke kelepona a hoʻonui i ka hana ikehu. He mea pili loa kēia hana i nā maʻi e pili ana i ka ʻelemakule, ʻoiai ʻo ka mitochondria hana ʻole e alakaʻi i ka hōʻiliʻili ʻana o ke kaumaha oxidative a me ka mumū. Hoʻoponopono pū ʻo UA i ka hōʻike ʻana o nā genes e pili ana i ka pane ʻana i ke kaumaha oxidative, ka hoʻoponopono DNA a me ka apoptosis, he mea nui ia no ka mālama ʻana i ka pono o ke kelepona a me ka pale ʻana i ka maʻi ʻaʻai.
ʻO kekahiʻO kahi ʻaoʻao hoihoi o UAkona hiki ke lilo i mea hoʻoheheʻe senescence, ʻo ia hoʻi hiki iā ia ke hoʻoulu koho i ka apoptosis i loko o nā cell senescent, ʻo ia hoʻi nā cell i hōʻino ʻia ʻaʻole e māhele hou akā hūnā i nā mea ʻino e hōʻino i nā cell a me nā ʻiʻo e pili ana. Pili nā cell senescent me nā maʻi like ʻole e pili ana i ka ʻelemakule, e like me ka arthritis, atherosclerosis a me neurodegeneration. Ma ka hoʻopau koho ʻana i kēia mau cell, hiki i ka UA ke hoʻopaneʻe a pale paha i ka hoʻomaka ʻana o kēia mau maʻi a hoʻomaikaʻi i ke olakino holoʻokoʻa.
ʻO nā Urolithins kahi papa o nā hui i ʻike ʻia ʻo nā metabolites ellagitannin, kahi i hana nui ʻia e ka microbiota ʻōpū. I waena o lākou, ʻelua mau molekala, ʻo urolithin A a me urolithin B, ua loaʻa ka nānā nui ʻia no ko lākou mau pono olakino. Loaʻa kēia mau hui i nā hua like ʻole e like me nā pomegerane, nā ʻōpena, a me nā raspberry. Ma kēia blog, e nānā pono mākou i nā waiwai pili o urolithin A a me urolithin B.
ʻO Urolithin A ka molekole nui loa o ka ʻohana urolithin, a ua noiʻi maikaʻi ʻia no kona mau waiwai antioxidant a me anti-inflammatory. Eia kekahi, ua hōʻike nā haʻawina e hiki i ka UA ke hoʻomaikaʻi i ka hana mitochondrial a pale i ka hōʻino ʻana o nā ʻiʻo. Ua ʻike ʻia hoʻi ʻo UA no kona mau waiwai anti-cancer hiki. Ua hōʻike ʻia ka noiʻi e hiki i ka UA ke kāohi i ka hoʻonui ʻana o nā cell a hoʻoulu i ka make ʻana o nā cell i nā laina cell cancer like ʻole, me nā cell cancer prostate, umauma, a me colon.
Ma ka ʻaoʻao ʻē aʻe, ua loaʻa i ka urolithin B ka nānā ʻana o nā mea noiʻi no kona hiki ke hoʻomaikaʻi i ke olakino o ka ʻōpū a hoʻēmi i ka mumū. Ua hōʻike ʻia nā haʻawina e hiki i ka UB ke hoʻonui i ka ʻokoʻa o nā microbial o ka ʻōpū a hoʻēmi i nā cytokines pro-inflammatory, e like me ka interleukin-6 a me ka tumor necrosis factor-alpha. Eia kekahi, ua ʻike ʻia hoʻi he mau waiwai neuroprotective ko UB, e like me ka hōʻike ʻana o nā haʻawina e hiki ke kōkua i ka pale ʻana i nā maʻi neurodegenerative e like me Parkinson's a me Alzheimer's.
ʻOiai ko lāua mau waiwai pili, he mau ʻokoʻa koʻikoʻi ko UA a me UB. No ka laʻana, ua hōʻike ʻia ʻoi aku ka ikaika o UA ma ke ʻano he mea anti-inflammatory a me antioxidant ma mua o UB. Ma ka ʻaoʻao ʻē aʻe, ua ʻike ʻia ʻoi aku ka maikaʻi o UB i ka pale ʻana i nā pilikia e pili ana i ka momona, e like me ke kūʻē ʻana o ka insulin a me ka hoʻokaʻawale ʻana o adipocyte. Eia kekahi, ʻaʻole like me UA, ʻaʻole i aʻo nui ʻia ʻo UB ma ke ʻano he mea anti-cancer.
He ʻokoʻa nō hoʻi ke ʻano hana no UA a me UB. Hoʻāla ʻo UA i ke ala Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), kahi e pāʻani ai i kahi kuleana i ka mitochondrial biogenesis, ʻoiai ʻo UB e hoʻoikaika i ke ala AMP-activated protein kinase (AMPK), kahi e pili ana i ka homeostasis ikehu. Hāʻawi kēia mau ala i nā hopena maikaʻi o kēia mau hui i ke olakino.
ʻOiai nā pono hoihoi o UA a me UB, aia nō nā palena i kā lākou hoʻohana ʻana. No ka laʻana, ʻoi aku ka haʻahaʻa o ka bioavailability o kēia mau hui, a ʻaʻole maopopo loa kā lākou pharmacokinetics. Eia kekahi, ʻaʻole i wehewehe piha ʻia ka hopena o kēia mau hui i nā kānaka, ʻoiai ua hana ʻia ka hapa nui o nā haʻawina ma vitro a i ʻole i nā hiʻohiʻona holoholona. Eia naʻe, hōʻike ka noiʻi e kū nei he hiki iā UA a me UB ke lilo i mau moho hoʻohiki no ka hoʻomohala ʻana i nā meaʻai hana a i ʻole nā mea hoʻohui e kākoʻo i ke olakino holoʻokoʻa a pale i nā maʻi.
ʻO Urolithin A. ʻO kēia mole liʻiliʻi i loaʻa maoli i loko o kekahi mau huaʻai a me nā nati he mea kaulana ia no kona hiki ke hoʻomaikaʻi i nā mea āpau mai ka ulu ʻana o nā ʻiʻo a hiki i ka hana o ka lolo. ʻO Urolithin A kahi metabolite, ʻo ia hoʻi he huahana ia o nā hui ʻē aʻe i loko o ke kino. ʻO ke kikoʻī, hana ʻia ia i ka wā e wāwahi ai nā bacteria ʻōpū i nā ellagitannins, i loaʻa i loko o kekahi mau meaʻai e like me nā pomegranate, nā ʻōpena a me nā walnuts. Akā eia ka ʻāpana hoihoi: ʻaʻole i loaʻa i nā kānaka a pau ka bacteria ʻōpū e pono ai e hana i ka urolithin A. ʻO kaʻoiaʻiʻo, ua hōʻike nā haʻawina he 30-50% wale nō o ka poʻe e hiki ke hana i kēia mole kūlohelohe. ʻO kēia kahi e pono ai nā mea hoʻohui.
No laila, he aha nānā pono o ka urolithin A? ʻĀ, ʻo kekahi o nā koi nui loa, hiki iā ia ke kōkua i ka hoʻomaikaʻi ʻana i ke olakino o nā ʻiʻo. Ua ʻike ʻia kahi noiʻi i paʻi ʻia ma ka puke pai ʻo Nature Medicine i ka wā i hāʻawi ʻia ai nā ʻiole i ka urolithin A, ua loaʻa iā lākou ka piʻi ʻana o 42% i ke ahonui a me ka piʻi ʻana o 70% i ka nui o nā ʻiʻo. ʻOiai he mea kupaianaha kēia mau hopena, he mea kūpono ke hoʻomaopopo ʻana he noiʻi liʻiliʻi kēia a pono e noiʻi hou aku e hōʻoia i kēia mau ʻike i loko o ke kanaka.
Akā, ʻaʻole ia wale nō ka mea i ʻōlelo ʻia e hana ai ka urolithin A. Ua hōʻike ʻia hoʻi e hoʻomaikaʻi i ka hana mitochondrial. ʻO ka Mitochondria nā mea kanu mana o nā cell, kuleana no ka hoʻoulu ʻana i ka ikehu e hiki i ke kino ke hoʻohana. I ko kākou ʻelemakule ʻana, hoʻomaka ka emi ʻana o kā kākou hana mitochondrial, hiki ke alakaʻi i nā pilikia olakino he nui. Eia nō naʻe, hōʻike ka noiʻi mua e hiki i ka urolithin A ke kōkua i ka hoʻolohi ʻana i kēia emi ʻana, e hoʻomaikaʻi ana i ke olakino holoʻokoʻa a hoʻolōʻihi i ka manaʻolana ola.
Me he mea lā ʻaʻole lawa kēlā, ua hōʻike ʻia hoʻi he mau pono noʻonoʻo ko ka urolithin A. Ua ʻike ʻia kahi noiʻi i paʻi ʻia ma ka puke pai ʻo Scientific Reports i ka wā i hāʻawi ʻia ai ka urolithin A i nā ʻiole, ua hoʻomaikaʻi ʻia ko lākou hoʻomanaʻo a me ka hiki ke aʻo. Manaʻo nā kānaka noiʻi he hopena anti-inflammatory paha kēia o ka mole, kahi e kōkua ai i ka pale ʻana i nā hunaola lolo mai ka hōʻino ʻia.
ʻO Urolithin B, kahi hui i loaʻa i loko o nā hua like ʻole a me nā pomegerane, ua ʻike ʻia no kona mau pono kūpono i ka hoʻomaikaʻi ʻana i ke olakino metabolic a me ka hoʻolōʻihi ʻana i ke ola. Ua hōʻike ʻia nā noiʻi hou he mau waiwai anti-inflammatory a me antioxidant ko urolithin B e hiki ke kōkua i ka pale ʻana i nā maʻi maʻi a hoʻomaikaʻi i ke olakino holoʻokoʻa.
1. Nā waiwai anti-inflammatory
ʻO ka mumū mau loa ke kumu nui o nā maʻi he nui, me ka maʻi puʻuwai, ka maʻi diabetes a me ke kanesa. Loaʻa iā Urolithin B nā waiwai anti-inflammatory e kōkua i ka hōʻemi ʻana i ka mumū i loko o ke kino, a laila e hōʻemi ana i ka pilikia o ka maʻi mau loa. Ua ʻike ʻia kekahi noiʻi ua hōʻemi nui ka urolithin B i ka mumū i nā ʻiole me ka maʻi mumū o ka ʻōpū, e hōʻike ana i kona pono kūpono i ka mālama ʻana i nā kānaka me nā maʻi like.
2. Nā waiwai antioxidant
He antioxidant ikaika ʻo Urolithin B, ʻo ia hoʻi hiki iā ia ke kōkua i ka pale ʻana i ke kino mai ke kaumaha oxidative, kahi hana e hōʻino ai i nā cell a paipai i ke kaʻina hana ʻelemakule. Kōkua ʻo Urolithin B i ka pale ʻana i ka pōʻino oxidative ma o ka hoʻopau ʻana i nā radical manuahi, hiki ke hōʻino i nā cellular a alakaʻi i nā maʻi maʻi. Ua ʻike ʻia kekahi noiʻi ua hōʻemi ka urolithin B i ke kaumaha oxidative i nā rodents, e kākoʻo hou ana i kona hiki ke lilo i mea hoʻohui anti-aging.
3. Hoʻolaha i ke olakino ʻiʻo
Ua hōʻike ʻia ʻo Urolithin B e hoʻoulu i ka mitochondrial autophagy, kahi hana cellular e kōkua i ka hoʻopau ʻana i ka mitochondria i hōʻino ʻia mai nā cell. Kōkua kēia hana i ka hoʻomaikaʻi ʻana i ke olakino a me ka hana o nā ʻiʻo holoʻokoʻa, e lilo ia i mea hoʻohui kūpono no ka poʻe e ʻimi nei e hoʻomaikaʻi i ka hana kino. Ua ʻike ʻia kekahi noiʻi ua hoʻomaikaʻi ka urolithin B i ka hana a me ka ikaika o nā ʻiʻo i nā ʻiole a me nā kānaka.
4. Kākoʻo i ke olakino noʻonoʻo
Ua hōʻike ʻia ʻo Urolithin B e kākoʻo i ke olakino noʻonoʻo ma o ka hoʻolaha ʻana i ka neuroplasticity, kahi hana e kōkua ai i ka lolo e hoʻololi i ka ʻike hou a hiki ke hoʻomaikaʻi i ka hana noʻonoʻo. Ua ʻike ʻia kekahi noiʻi ua hoʻomaikaʻi ka urolithin B i ka hana noʻonoʻo a hoʻonui i ka hoʻomanaʻo i nā ʻiole.
5. Nā pono kūpono no ke ola lōʻihi
Ua hōʻike ʻia nā haʻawina hou e hiki i ka urolithin B ke hoʻolaha i ke ola lōʻihi ma o ka hoʻomaikaʻi ʻana i ke olakino metabolic, ka hōʻemi ʻana i ka mumū, a me ka pale ʻana i ke kaumaha oxidative. Ua ʻike ʻia kekahi haʻawina ua hoʻonui ka urolithin B i ke ola ma C. elegans, kahi ʻano ilo nematode, e kākoʻo ana i kona mau pono kūpono no ka hoʻolaha ʻana i ke ola lōʻihi.
1. Pomegranate
ʻO ka pomegranate kekahi o nā kumu maikaʻi loa o ka urolithin. Ua ʻike nā kānaka noiʻi hiki i ka wai pomegranate ke hoʻonui i nā pae koko o nā urolithins A a me B. Eia kekahi, he mau pono olakino ʻē aʻe ko nā pomegranate, me nā waiwai anti-inflammatory a me antioxidant.
2. Nā hua
ʻO nā hua e like me nā ʻōpena, nā raspberries a me nā blackberries he mau kumu maikaʻi nō hoʻi o ka urolithin. Ua hōʻike ʻia nā noiʻi e hiki i ka ʻai ʻana i nā hua ke hoʻonui i nā pae koko o ka urolithin A a me B.
3. Nā nati
He kumu maikaʻi nō hoʻi nā walnuts a me nā pecans a me nā nati ʻē aʻe no ka urolithin. Ua ʻike ʻia kahi noiʻi e hoʻonui ka ʻai ʻana i nā nati i ka pae o ka urolithin A a me B i loko o ke koko.
ʻO Urolithin A a me B nā hui kūlohelohe i loaʻa i kekahi mau meaʻai, he nui ko lākou mau pono olakino. Loaʻa i kēia mau hui nā waiwai anti-inflammatory, hoʻomaikaʻi i ke olakino mitochondrial a me nā ʻiʻo, a paipai i ke olakino noʻonoʻo. ʻO nā pomegranate, nā hua, nā nati a me nā mea hoʻohui ellagitannin kekahi o nā kumu meaʻai maikaʻi loa e hiki ke hāʻawi i nā urolithins. ʻO ka hoʻokomo ʻana i kēia mau meaʻai i kāu meaʻai e hiki ke kōkua iā ʻoe e wehe i nā pono o nā urolithins A a me B a paipai i ka ʻelemakule olakino.
Ka manawa hoʻouna: Iune-05-2023
