ʻO Urolithin A nā pūhui kūlohelohe he mau pūhui metabolite i hana ʻia e nā maʻi maʻi ʻōpū e hoʻohuli i nā ellagitannins e hoʻomaikaʻi i ke olakino ma ka pae kelepona. Ua loaʻa iā Urolithin B ka manaʻo o ka poʻe noiʻi no kona hiki ke hoʻomaikaʻi i ke olakino ʻōpū a hoʻemi i ka mumū. He mau waiwai pili ka Urolithin A a me ka urolithin B, akā aia kekahi mau ʻokoʻa like ʻole. He aha nā ʻokoʻa kikoʻī iā ʻoe, e ʻike kākou!
I nā makahiki i hala iho nei, ke aʻo nei nā kānaka ʻepekema i nā pono olakino o ka urolithin, kahi hui kūlohelohe he mea metabolite i hana ʻia e ka hoʻololi ʻana o nā ellagitannins e nā maʻi bacteria intestinal. ʻO kāna mau mea mua he ʻakika ellagic a me nā ellagitannins, ka mea i loaʻa maoli i nā kumu meaʻai e like me ka pomegerane, guava, kī, pecans, nati, a me nā hua e like me nā strawberries, nā raspberry ʻeleʻele, a me nā ʻeleʻele. Eia kekahi, ʻo ka urolithin A, he polyphenol maoli, he mea hoihoi ia ma ke ʻano he antioxidant potent a me ka anti-inflammatory agent me nā pono olakino maikaʻi.
Snā haʻawina e noiʻi ana i ka thUa hōʻike ʻia nā hopena o UA ma nā hana kelepona a me nā ala olaola he nui nā ʻano hana. Ua ʻike pū ʻia nā haʻawina e hoʻāla ka UA i ka mitochondrial autophagy, kahi kaʻina e hoʻoneʻe i ka mitochondria poino mai ke kelepona a hoʻonui i ka hana ikehu. Pili loa kēia hana i nā maʻi e pili ana i ka ʻelemakule, ʻoiai ke alakaʻi nei ka mitochondria dysfunctional i ka hōʻiliʻili ʻana o ke kaumaha oxidative a me ka mumū. Hoʻoponopono pū ʻo UA i ka hōʻike ʻana o nā genes e pili ana i ka pane ʻana i ke koʻikoʻi oxidative, ka hoʻoponopono DNA a me ka apoptosis, he mea nui ia no ka mālama pono ʻana i ka cellular a me ka pale ʻana i ka maʻi kanesa.
ʻO kekahir mea hoihoi o UAʻO kona hiki ke lilo i mea ʻokiʻoki, ʻo ia hoʻi, hiki iā ia ke hoʻoulu koho i ka apoptosis i loko o nā cell senescent, ʻo ia nā cell i hōʻino ʻia ʻaʻole e puʻunaue hou akā hūnā i nā mea ʻino e hōʻino ai i nā cell a me nā ʻiʻo kokoke. Hoʻopili ʻia nā cell Senescent me nā maʻi e pili ana i ka ʻelemakule, e like me ka arthritis, atherosclerosis a me neurodegeneration. Ma ka hoʻopau koho ʻana i kēia mau cell, hiki iā UA ke hoʻopanee a pale i ka hoʻomaka ʻana o kēia mau maʻi a hoʻomaikaʻi i ke olakino holoʻokoʻa.
ʻO Urolithins kahi papa o nā pūhui i kapa ʻia ʻo ellagitannin metabolites, ka mea i hana nui ʻia e ka microbiota gut. Ma waena o lākou, ʻelua mau molekala, ʻo urolithin A a me urolithin B, ua loaʻa ka manaʻo nui no kā lākou pono olakino. Loaʻa kēia mau mea i loko o nā hua like ʻole e like me nā pomegerane, strawberries, a me nā raspberry. Ma kēia blog, e nānā pono mākou i nā waiwai pili o urolithin A a me urolithin B.
ʻO Urolithin A ka molela nui loa o ka ʻohana urolithin, a ua noiʻi maikaʻi ʻia no kāna mau waiwai antioxidant a me nā anti-inflammatory. Eia kekahi, ua manaʻo nā haʻawina e hiki i ka UA ke hoʻomaikaʻi i ka hana mitochondrial a pale i ka pōʻino o ka ʻiʻo. ʻIke ʻia ʻo UA no kāna mau waiwai anti-cancer. Ua hōʻike ʻia ka noiʻi ʻana hiki iā UA ke kāohi i ka hoʻonui ʻana o nā cell a hoʻoulu i ka make cell i nā laina maʻi maʻi like ʻole, e like me ka prostate, ka umauma, a me ka maʻi kanesa colon.
Ma ka ʻaoʻao ʻē aʻe, ua loaʻa i ka urolithin B ka nānā ʻana o ka poʻe noiʻi no kona hiki ke hoʻomaikaʻi i ke olakino ʻōpū a hoʻemi i ka mumū. Ua hōʻike nā haʻawina e hiki i ka UB ke hoʻonui i ka ʻokoʻa microbial gut a hōʻemi i nā cytokine pro-inflammatory, e like me interleukin-6 a me ka tumor necrosis factor-alpha. Eia kekahi, ua ʻike ʻia ʻo UB he mau waiwai neuroprotective, ʻoiai ua hōʻike ʻia nā haʻawina e hiki ke kōkua i ka pale ʻana i nā maʻi neurodegenerative e like me Parkinson's a me Alzheimer's.
ʻOiai ko lākou mau waiwai pili, loaʻa iā UA a me UB kekahi mau ʻokoʻa koʻikoʻi. No ka laʻana, ua hōʻike ʻia ʻo UA i ʻoi aku ka ikaika ma ke ʻano he anti-inflammatory a antioxidant agent ma mua o UB. Ma kekahiʻaoʻao, uaʻikeʻiaʻo UB iʻoi aku ka maikaʻi i ka paleʻana i nā pilikia pili i ka momona, e like me ke kū'ēʻana o ka insulin a me kaʻokoʻa adipocyte. Eia hou, ʻaʻole like me UA, ʻaʻole i aʻo nui ʻia ʻo UB ma ke ʻano he lāʻau anti-cancer.
ʻOkoʻa nō hoʻi ke ʻano o ka hana no UA a me UB. Hoʻoulu ʻo UA i ke alahele Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), kahi hana i ka mitochondrial biogenesis, ʻoiai ʻo UB e hoʻonui i ke ala AMP-activated protein kinase (AMPK), kahi i komo i ka homeostasis ikehu. Hāʻawi kēia mau ala i nā hopena maikaʻi o kēia mau pūhui i ke olakino.
ʻOiai nā pōmaikaʻi hoihoi o UA a me UB, aia nō nā palena i kā lākou hoʻohana. No ka laʻana, ʻoi aku ka haʻahaʻa o ka bioavailability o kēia mau pūhui, a ʻaʻole maopopo i kā lākou pharmacokinetics. Eia kekahi, ʻaʻole i wehewehe piha ʻia ka hopena o kēia mau pūhui i ke kanaka, no ka mea, ua hana ʻia ka hapa nui o nā haʻawina i loko o ka vitro a i ʻole i nā ʻano holoholona. Eia nō naʻe, ʻo ka noiʻi e kū nei e hōʻike ana he hiki i ka UA a me UB ke hoʻohiki i nā moho no ka hoʻomohala ʻana i nā meaʻai hana a i ʻole nā mea hoʻohui e kākoʻo i ke olakino holoʻokoʻa a pale i nā maʻi.
Urolithin A. ʻO kēia mole liʻiliʻi liʻiliʻi i loaʻa maoli i loko o kekahi mau huaʻai a me nā nati i kaulana no kona hiki ke hoʻomaikaʻi i nā mea āpau mai ka ulu ʻana o ka ʻiʻo a hiki i ka hana o ka lolo. ʻO Urolithin A he metabolite, ʻo ia hoʻi he huahana ia o nā pūhui ʻē aʻe i loko o ke kino. ʻO ke kikoʻī, hana ʻia ia i ka wā e wāwahi ai nā huakini ʻōpū i nā ellagitannins, i loaʻa i kekahi mau meaʻai e like me nā pomegerane, nā strawberries a me nā walnuts. Eia naʻe ka ʻāpana hoihoi: ʻaʻole i loaʻa i nā kānaka a pau ka bacteria ʻōpū e pono ai e hana i ka urolithin A. ʻOiaʻiʻo, ua hōʻike ʻia nā haʻawina e hiki wale i ka 30-50% o nā kānaka ke hana i kēia mole ma ke ʻano kūlohelohe. ʻO kēia kahi kahi e hiki mai ai nā mea hoʻohui.
No laila, he ahanā pono o ka urolithin A? ʻAe, ʻo kekahi o nā ʻōlelo nui e hiki ke kōkua i ka hoʻomaikaʻi ʻana i ke ola kino. Ua ʻike ʻia kahi haʻawina i paʻi ʻia ma ka puke pai Nature Medicine i ka wā i hāʻawi ʻia ai nā ʻiole i ka urolithin A, ua loaʻa iā lākou he 42% hoʻonui i ka hoʻomanawanui a me ka piʻi ʻana o 70% i ka nui o ka ʻiʻo. ʻOiai he mea kupanaha kēia mau hopena, pono e ʻike ʻia he haʻawina liʻiliʻi kēia a pono e noiʻi hou aku e hōʻoia i kēia mau ʻike i ke kanaka.
Akā ʻaʻole ʻo ia wale ka urolithin A i ʻōlelo ʻia e hana. Ua hōʻike ʻia e hoʻomaikaʻi i ka hana mitochondrial. ʻO Mitochondria nā mea kanu mana o nā cell, kuleana no ka hoʻoulu ʻana i ka ikehu i hiki i ke kino ke hoʻohana. I ko mākou mau makahiki, hoʻomaka kā mākou hana mitochondrial e emi iho, hiki ke alakaʻi i nā pilikia olakino. Eia nō naʻe, hōʻike ka noiʻi mua e hiki i ka urolithin A ke kōkua i ka hoʻolōʻihi ʻana i kēia emi ʻana, hiki ke hoʻomaikaʻi i ke olakino holoʻokoʻa a hoʻonui i ke ola.
Me he mea lā ʻaʻole lawa ia, ua hōʻike pū ʻia ka urolithin A i nā pono cognitive. Ua ʻike ʻia kahi haʻawina i paʻi ʻia ma ka puke pai Scientific Reports i ka wā i hāʻawi ʻia ai nā ʻiole i ka urolithin A, ua hoʻomaikaʻi ko lākou hoʻomanaʻo a me ka hiki ke aʻo. Manaʻo ka poʻe noiʻi ma muli paha o ka hopena anti-inflammatory o ka mole, e kōkua ana i ka pale ʻana i nā cell lolo mai ka pōʻino.
ʻO Urolithin B, kahi pūhui i loaʻa i nā hua like ʻole a me nā pomegerane, ua ʻike ʻia no kāna mau pono kūpono i ka hoʻomaikaʻi ʻana i ke olakino metabolic a hoʻonui i ke ola. Ua hōʻike ʻia nā haʻawina hou i ka urolithin B he anti-inflammatory a me nā waiwai antioxidant e hiki ke kōkua i ka pale ʻana i nā maʻi maʻi a hoʻomaikaʻi i ke olakino holoʻokoʻa.
1. Nā waiwai anti-inflammatory
ʻO ka maʻi ʻeha ke kumu nui o nā maʻi he nui, e like me ka maʻi puʻuwai, ka maʻi diabetes a me ka maʻi kanesa. Loaʻa i ka Urolithin B nā waiwai anti-inflammatory e kōkua i ka hoʻohaʻahaʻa ʻana i ke kino, a laila e hōʻemi i ka hopena o ka maʻi maʻi. Ua ʻike ʻia kahi noiʻi ua hoʻemi nui ka urolithin B i nā ʻiole me ka maʻi ʻeha o ka ʻōpū, e hōʻike ana i kona hiki ke hana i ka mālama ʻana i nā kānaka me nā maʻi like.
2. Nā waiwai antioxidant
ʻO Urolithin B he antioxidant ikaika, ʻo ia ka mea hiki ke kōkua i ka pale ʻana i ke kino mai ke kaumaha oxidative, kahi hana e hōʻino ai i nā cell a hoʻoikaika i ke kaʻina hana ʻelemakule. Kōkua ʻo Urolithin B i ka pale ʻana i ka pōʻino oxidative ma o ka hoʻokaʻawale ʻana i nā radical manuahi, hiki ke hōʻino i nā kelepona a alakaʻi i ka maʻi maʻi. Ua ʻike ʻia kahi noiʻi ua hoʻemi ʻo urolithin B i ke koʻikoʻi oxidative i nā rodents, e kākoʻo hou ana i kona hiki ke lilo i mea hoʻohui anti-aging.
3. Hoʻoikaika i ke ola kino
Ua hōʻike ʻia ʻo Urolithin B e hoʻoulu i ka mitochondrial autophagy, kahi kaʻina cellular e kōkua i ka hoʻopau ʻana i ka mitochondria pōʻino mai nā cell. Kōkua kēia kaʻina hana i ka hoʻomaikaʻi ʻana i ke olakino a me ka hana o ka ʻiʻo holoʻokoʻa, e lilo ia i mea hoʻohui kūpono no ka poʻe e ʻimi nei e hoʻomaikaʻi i ka hana kino. Ua ʻike ʻia kahi noiʻi ua hoʻomaikaʻi ʻo urolithin B i ka hana ʻiʻo a me ka ikaika i nā ʻiole a me nā kānaka.
4. Kākoʻo i ke ola kino
Ua hōʻike ʻia ʻo Urolithin B e kākoʻo i ke olakino noʻonoʻo ma o ka hoʻolaha ʻana i ka neuroplasticity, kahi hana e kōkua ai i ka lolo e hoʻololi i ka ʻike hou a hiki ke hoʻomaikaʻi i ka hana cognitive. Ua ʻike kekahi haʻawina ua hoʻomaikaʻi ʻo urolithin B i ka hana cognitive a hoʻonui i ka hoʻomanaʻo i nā ʻiole.
5. Loaʻa nā pōmaikaʻi ola lōʻihi
Ua hōʻike ʻia nā haʻawina hou he hiki i ka urolithin B ke hoʻoikaika i ka lōʻihi ma o ka hoʻomaikaʻi ʻana i ke olakino metabolic, hōʻemi i ka mumū, a me ka pale ʻana i ke kaumaha oxidative. Ua ʻike kekahi haʻawina ua hoʻonui ka urolithin B i ke ola o C. elegans, kahi ʻano ilo nematode, e kākoʻo ana i kāna mau pono kūpono no ka hāpai ʻana i ka lōʻihi.
1. Pomegerane
ʻO ka pomegranate kekahi o nā kumu maikaʻi loa o ka urolithin. Uaʻike nā mea noiʻi hiki i ka wai pomegranate ke hoʻonui i ke koko o ka urolithins A a me B. Eia kekahi, loaʻa i nā pomegerane nā pono olakino'ē aʻe, e like me nā mea anti-inflammatory a me nā antioxidants.
2. Nā hua hua
ʻO nā hua e like me nā strawberries, nā raspberries a me nā ʻeleʻele kekahi kumu maikaʻi o ka urolithin. Ua hōʻike ʻia nā haʻawina e hiki ke hoʻonui i ka pae koko o ka urolithin A a me B.
3. Nati
ʻO nā walnuts a me nā pecans a me nā nati ʻē aʻe kekahi kumu maikaʻi o ka urolithin. Ua ʻike ʻia kahi haʻawina ʻo ka ʻai ʻana i nā nati e hoʻonui i ke kiʻekiʻe o ka urolithin A a me B i loko o ke koko.
ʻO Urolithin A a me B nā pūhui kūlohelohe i loaʻa i kekahi mau meaʻai, he nui nā pono olakino. Loaʻa i kēia mau pūhui nā waiwai anti-inflammatory, hoʻomaikaʻi i ke olakino mitochondrial a me ka ʻiʻo, a hoʻoikaika i ke olakino cognitive. ʻO nā pomegerane, nā hua, nā nati a me nā mea hoʻohui ellagitannin kekahi o nā kumu meaʻai maikaʻi loa e hiki ke hāʻawi i nā urolithins. ʻO ka hoʻokomo ʻana i kēia mau meaʻai i kāu meaʻai hiki ke kōkua iā ʻoe e wehe i nā pono o nā urolithins A a me B a hoʻoikaika i ka ʻelemakule olakino.
Ka manawa hoʻouna: Jun-05-2023
