I nā makahiki i hala iho nei, ua ulu nui ka hoihoi i nā hui kūlohelohe e hiki ke hoʻonui i ke olakino holoʻokoʻa a me ka noho maikaʻi ʻana. ʻO Urolithin A a me urolithin B ʻelua mau hui kūlohelohe i loaʻa mai nā ellagitannins i loaʻa i loko o kekahi mau huaʻai a me nā nati. ʻO kā lākou mau waiwai anti-inflammatory, antioxidant, a me ke kūkulu ʻana i nā ʻiʻo e hoʻolilo iā lākou i mau hui hoihoi no ka hoʻolaha ʻana i ke olakino holoʻokoʻa. ʻOiai he mau waiwai pili ko urolithin A a me urolithin B, he mau ʻokoʻa koʻikoʻi ko lākou.
ʻO Urolithin A a me B nā metabolites i hana maoli ʻia i loko o ke kino o ke kanaka ma muli o ka ʻai ʻana o kekahi mau meaʻai, ʻo ia hoʻi nā ellagitannins. Loaʻa nā Ellagitannins i nā huaʻai a me nā nati like ʻole, me nā pomegerane, nā ʻōpena, nā raspberries, nā blackberries, a me nā walnuts. Eia nō naʻe, he hapa liʻiliʻi wale nō o ka heluna kanaka i loaʻa nā bacteria ʻōpū e hiki ai ke hoʻololi i nā ellagitannins i nā urolithins, e hoʻololi nui ana i nā pae urolithin i loko o nā kānaka.
No ka poʻe i pilikia i ka hoʻokō ʻana i kā lākou mau pono magnesium ma o ka ʻai wale nō, hiki i nā mea hoʻopihapiha magnesium ke pōmaikaʻi i ke olakino ma nā ʻano he nui a loaʻa i nā ʻano e like me ka magnesium oxide, magnesium threonate, magnesium taurate, a me ka magnesium glycinate. Eia nō naʻe, ua ʻōlelo ʻia e kūkākūkā me kahi loea mālama ola ma mua o ka hoʻomaka ʻana i kekahi regimen hoʻopihapiha e pale aku i nā pilina a i ʻole nā pilikia.
ʻO Urolithin A ka molekole nui loa i ka ʻohana urolithin, a ua aʻo maikaʻi ʻia kona mau waiwai antioxidant a me anti-inflammatory. Ua hōʻike ʻia nā haʻawina e hiki i ka urolithin A ke hoʻomaikaʻi i ka hana mitochondrial a pale i ka hōʻino ʻana o nā ʻiʻo. Eia kekahi, ua hōʻike ʻia nā haʻawina e hiki i ka urolithin A ke kāohi i ka hoʻonui ʻana o nā cell a hoʻoulu i ka make ʻana o nā cell i nā ʻano laina cell cancer like ʻole.
Ua huki ʻo Urolithin B i ka manaʻo o nā mea noiʻi no kona hiki ke hoʻomaikaʻi i ke olakino ʻōpū a hōʻemi i ka mumū. Hōʻike ka noiʻi hiki i ka urolithin B ke hoʻonui i ka ʻokoʻa o nā microbial gut a hōʻemi i nā cytokines pro-inflammatory e like me ka interleukin-6 a me ka tumor necrosis factor alpha. Eia kekahi, ua ʻike ʻia he mau waiwai neuroprotective hiki i ka urolithin B, me nā haʻawina e hōʻike ana hiki iā ia ke kōkua i ka pale ʻana i nā maʻi neurodegenerative e like me Parkinson's a me Alzheimer's.
ʻOiai he mau waiwai pili ko urolithin A a me urolithin B, he mau ʻokoʻa ko lākou. No ka laʻana, ua hōʻike ʻia ʻoi aku ka maikaʻi o ka urolithin A ma ke ʻano he anti-inflammatory a me antioxidant ma mua o ka urolithin B. Ma ka ʻaoʻao ʻē aʻe, ua ʻike ʻia ʻo Urolithin B he ʻoi aku ka maikaʻi i ka pale ʻana i nā pilikia e pili ana i ka momona, e like me ke kūʻē ʻana o ka insulin a me ka hoʻokaʻawale ʻana o ka adipocyte.
He ʻokoʻa nō hoʻi nā ʻano hana o ka urolithin A a me ka urolithin B. Hoʻāla ʻo Urolithin A i ke ala o ka peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), kahi e pāʻani ai i kahi kuleana i ka mitochondrial biogenesis, ʻoiai ʻo urolithin B e hoʻoikaika i ke ala AMP-activated protein kinase (AMPK), kahi e pili ana i ka homeostasis ikehu. Hāʻawi kēia mau ala i nā hopena olakino maikaʻi o kēia mau hui.
●Nā Waiwai Anti-inflammatory
Ua ʻike ʻia ka mumū mau loa e kōkua i kekahi mau maʻi. Ua hōʻike ʻia ʻo Urolithin A he mau waiwai anti-inflammatory ikaika, e hōʻemi ana i ka hana ʻana o nā molekala mumū. Ma ka hoʻopau ʻana i ka mumū, hiki iā ia ke kōkua i ka mālama ʻana i nā ʻano maʻi like ʻole e like me ka arthritis, ka maʻi puʻuwai, a me kekahi mau ʻano maʻi kanesa.
●Ola Kino a me ka Ikaika
I ko kākou ʻelemakule ʻana, lilo ka nalowale ʻana o nā ʻiʻo iwi i mea hopohopo nui. Ua ʻike ʻia ʻo Urolithin A e hoʻoulu i ka ulu ʻana o nā hunaola ʻiʻo a hoʻonui i ka hana ʻiʻo, e paipai ana i ke olakino a me ka ikaika o nā ʻiʻo. He manaʻolana kēia no nā poʻe e ʻimi nei e mālama i ka nui o nā ʻiʻo a hakakā i ka emi ʻana o nā ʻiʻo e pili ana i ka ʻelemakule.
●Ola kino Mitochondrial a me ka lōʻihi o ke ola
Hōʻike ʻo Urolithin A i nā hopena ikaika ma ka mitochondria, i kapa pinepine ʻia ʻo nā hale mana o kā mākou mau cell. Hoʻomaka ia i kahi kaʻina hana i kapa ʻia ʻo mitophagy, kahi e pili ana i ka wehe koho ʻana i nā mitochondria i hōʻino ʻia. Ma ka hoʻolaha ʻana i ka hana mitochondrial olakino, hiki i ka urolithin A ke kōkua i ka lōʻihi o ke ola a pale aku i nā kūlana e pili ana i ka makahiki e like me nā maʻi neurodegenerative.
●Hana Antioxidant
He antioxidant ikaika ʻo Urolithin B e kōkua ana i ka hoʻopau ʻana i nā radical manuahi ʻino i loko o ke kino. He mau molekala pane wikiwiki nā radical manuahi e hiki ke kōkua i ka hōʻino ʻana o nā cellular a me ke kaumaha oxidative, i pili i nā maʻi like ʻole. Kōkua ka hana antioxidant o Urolithin B i ka pale ʻana i kā mākou mau cell mai ia mau hōʻino a hiki ke hōʻemi i ka pilikia o nā maʻi maʻi.
●Ola Kino a me ka Hoʻololi ʻana o ka Microbiome
He kuleana koʻikoʻi ko ko kākou ʻōpū i ko kākou olakino holoʻokoʻa, a ua kū mai ka urolithin B ma ke ʻano he mea nui i ka mālama ʻana i kahi microbiome ʻōpū olakino. Hoʻolaha ia i ka ulu ʻana o nā pono.nā bacteria olakino a kāohi i ka ulu ʻana o nā bacteria ʻino, no laila e hānai ana i kahi kaiapuni microbial kaulike. ʻO kahi microbiome ʻōpū kūpono e pili pū ana me ka hoʻomaikaʻi ʻana i ka ʻai ʻana, ka hana pale, a me ka maikaʻi o ka noʻonoʻo.
●Hoʻolaha i ke olakino o nā ʻiʻo
Ua hōʻike ʻia ʻo Urolithin B e hoʻoulu i ka mitochondrial autophagy, kahi hana cellular e kōkua i ka hoʻopau ʻana i ka mitochondria i hōʻino ʻia mai nā cell. Kōkua kēia hana i ka hoʻomaikaʻi ʻana i ke olakino a me ka hana o nā ʻiʻo holoʻokoʻa, e lilo ia i mea hoʻohui kūpono no ka poʻe e ʻimi nei e hoʻomaikaʻi i ka hana kino. Ua ʻike ʻia kekahi noiʻi ua hoʻomaikaʻi ka urolithin B i ka hana a me ka ikaika o nā ʻiʻo i nā ʻiole a me nā kānaka.
Hoʻopuka ʻia nā Urolithins i loko o ko mākou kino ma hope o ka ʻai ʻana i kekahi mau meaʻai i loaʻa nā ellagitannins. ʻO nā kumu meaʻai nui o nā ellagitannins e komo pū me:
a) Nā pomegerane
ʻO nā pomegranate kekahi o nā kumu meaʻai waiwai nui o nā ellagitannins, kahi i hoʻololi ʻia i urolithin A a me urolithin B e nā bacteria o ka ʻōpū. ʻO ka ʻai ʻana i nā hua pomegranate, wai, a i ʻole nā mea i hoʻohui ʻia e hiki ke hoʻonui i kāu lawe ʻana i kēia mau pūhui ikaika, e hoʻomaikaʻi ana i ke olakino o nā cell a me ka hoʻokō ʻana i nā hopena anti-inflammatory.
b) Nā huaʻai
Loaʻa i nā hua like ʻole e like me nā ʻōpena, nā raspberry, a me nā blackberry nā pae kiʻekiʻe o nā ellagitannins. Ua hōʻike ʻia nā haʻawina e hoʻolaha ana ka ʻai ʻana i kēia mau hua olaola i ka hana ʻana o ka urolithin A a me ka urolithin B i loko o ka ʻōpū. ʻO ka hoʻohui ʻana i nā hua i kāu meaʻai ʻaʻole wale e hoʻonui i ka ʻono akā hāʻawi pū kekahi i nā pono olakino lōʻihi.
c) Nā nati
ʻO nā nati, ʻoiai nā walnuts a me nā pecans, he mau kumu waiwai nui ia o nā ellagitannins. Eia kekahi, ua piha lākou i nā momona olakino, fiber, a me nā meaʻai koʻikoʻi ʻē aʻe. ʻO ka hoʻokomo ʻana i nā nati i kāu papaʻai i kēlā me kēia lā ʻaʻole wale nō e hāʻawi i ka urolithin A a me B akā hāʻawi pū kekahi i nā pono olakino like ʻole no ka puʻuwai, ka lolo, a me ke olakino holoʻokoʻa.
d) Nā waina ʻoka i hoʻoulu ʻia
ʻOiai paha he mea kupanaha ia, ʻo ka hoʻohana kaulike ʻana i ka waina ʻulaʻula i hoʻomaʻamaʻa ʻia i ka ʻoka hiki ke kōkua i ka hana urolithin. Hiki ke unuhi ʻia nā hui i loaʻa i loko o nā pahu ʻoka i hoʻohana ʻia no ka hoʻomaʻamaʻa ʻana i ka waina i ka wā o ke kaʻina hana ʻelemakule, e hoʻokomo ana i ka waina me nā ellagitannins. Eia nō naʻe, he mea nui e hoʻomanaʻo he hopena maikaʻi ʻole ka inu ʻona nui i ke olakino, no laila he mea nui ka hoʻomalu ʻana.
e) Nā mea kanu waiwai i ka Ellagitannin
Ma waho aʻe o nā pomegerane, aia kekahi mau mea kanu e like me ka ʻili lāʻau ʻoka, nā ʻōpena, a me nā lau ʻoka i loko o nā ellagitannins. ʻO ka hoʻokomo ʻana i kēia mau mea kanu i kāu meaʻai e kōkua paha i ka hoʻonui ʻana i nā pae o ka urolithin A a me ka urolithin B i loko o kou kino, e kākoʻo ana i ke olakino o nā cellular a me ka hoʻomaikaʻi ʻana i ke olakino holoʻokoʻa.
E hoʻokomourolithin A a me B i kou nohona, ʻo kahi ala kūpono ka ʻai ʻana i nā meaʻai waiwai i nā ellagitannins. He mau kumu maikaʻi loa nā pomegranate, nā ʻōpena, nā raspberry, a me nā walnuts.
Eia nō naʻe, he mea nui e hoʻomaopopo he ʻokoʻa ka nui o ka ellagitannin i loko o kēlā me kēia hua, a ʻaʻole like ka microbiota ʻōpū o kēlā me kēia kanaka i hiki ke hoʻololi i nā ellagitannins i nā urolithins. No laila, ʻaʻole paha e hana pono kekahi poʻe i nā urolithins mai kēia mau kumu meaʻai. ʻO nā mea hoʻohui kekahi koho e hōʻoia i ka lawa ʻana o ka urolithin A a me B.
Q: Pehea e hoʻolaha ai ʻo Urolithin A a me Urolithin B i ke olakino mitochondrial?
A: Hoʻāla ʻo Urolithin A a me Urolithin B i kahi ala cellular i kapa ʻia ʻo mitophagy, nona ke kuleana no ka wehe ʻana i nā mitochondria i hōʻino ʻia mai nā cell. Ma ka hoʻolaha ʻana i ka mitophagy, kōkua kēia mau hui i ka mālama ʻana i kahi heluna mitochondrial olakino, he mea nui ia no ka hana ʻana i ka ikehu a me ka hana cellular holoʻokoʻa.
Nīnau: Hiki ke loaʻa iā Urolithin A a me Urolithin B ma o nā mea hoʻohui?
ʻAe, loaʻa nā mea hoʻohui Urolithin A a me Urolithin B ma ka mākeke. Eia nō naʻe, he mea nui e hoʻomaopopo he ʻokoʻa paha ka pono a me ka palekana o kēia mau mea hoʻohui. Manaʻo ʻia e kūkākūkā me kahi loea mālama ola ma mua o ka hoʻomaka ʻana i nā mea hoʻohui meaʻai hou.
ʻŌlelo Hoʻolaha: No ka ʻike wale nō kēia ʻatikala a ʻaʻole pono e manaʻo ʻia he ʻōlelo aʻoaʻo lapaʻau. E kūkākūkā mau me kahi loea mālama ola ma mua o ka hoʻohana ʻana i nā mea hoʻohui a i ʻole ka hoʻololi ʻana i kāu papa hana mālama ola.
Ka manawa hoʻouna: Sep-13-2023
