I kēia mau makahiki i hala iho nei, ua ulu nui ka hoihoi i nā pūhui kūlohelohe e hiki ke hoʻonui i ke olakino a me ka maikaʻi. ʻO Urolithin A a me urolithin B ʻelua mau pūhui kūlohelohe i loaʻa mai nā ellagitannins i loaʻa i kekahi mau huaʻai a me nā nati. ʻO kā lākou mau mea anti-inflammatory, antioxidant, a me nā ʻiʻo-kūkulu ʻana i nā ʻiʻo e lilo lākou i mea hoihoi no ka hoʻolaha ʻana i ke olakino holoʻokoʻa. ʻOiai he mau waiwai pili ka urolithin A a me ka urolithin B, aia kekahi mau ʻokoʻa koʻikoʻi.
ʻO Urolithin A a me B nā metabolites i hana maoli ʻia i loko o ke kino o ke kanaka ma muli o ka ʻeli ʻana o kekahi mau meaʻai, ʻo ia hoʻi nā ellagitannins. Aia nā Ellagitannins i nā huaʻai like ʻole a me nā nati, e like me nā pomegerane, strawberries, raspberries, blackberries, a me nā walnuts. Eia nō naʻe, he hapa liʻiliʻi wale nō o ka heluna kanaka i loaʻa i ka maʻi bacteria e hiki ke hoʻololi i nā ellagitannins i urolithins, e hoʻololi i nā pae urolithin i kēlā me kēia kanaka.
No ka poʻe paʻakikī e hoʻokō i kā lākou mau pono magnesium ma o ka meaʻai wale nō, hiki i nā mea hoʻohui magnesium ke pōmaikaʻi i ke olakino ma nā ʻano he nui a hele mai i nā ʻano like me ka magnesium oxide, magnesium threonate, magnesium taurate, a me ka magnesium glycinate. Eia nō naʻe, ʻōlelo ʻia e nīnau i kahi ʻoihana mālama ola ma mua o ka hoʻomaka ʻana i kekahi regimen supplementation e pale aku i nā pilina a i ʻole nā pilikia.
ʻO Urolithin A ka mea nui loa i ka ʻohana urolithin, a ua aʻo maikaʻi ʻia kāna mau antioxidant a me nā mea anti-inflammatory. Ua hōʻike nā haʻawina e hiki i ka urolithin A ke hoʻomaikaʻi i ka hana mitochondrial a pale i ka pōʻino o ka ʻiʻo. Eia kekahi, ua hōʻike nā haʻawina e hiki i ka urolithin A ke kāohi i ka hoʻonui ʻana o ka cell a hoʻoulu i ka make cell i nā ʻano laina maʻi maʻi.
Ua hoʻokipa ʻo Urolithin B i ka manaʻo o nā mea noiʻi no kona hiki ke hoʻomaikaʻi i ke olakino ʻōpū a hoʻemi i ka mumū. Hōʻike ka noiʻi hiki i ka urolithin B ke hoʻonui i ka ʻokoʻa microbial gut a hoʻemi i nā cytokine pro-inflammatory e like me interleukin-6 a me ka tumor necrosis factor alpha. Eia kekahi, ua ʻike ʻia ka urolithin B i nā waiwai neuroprotective, me nā haʻawina e hōʻike ana hiki ke kōkua i ka pale ʻana i nā maʻi neurodegenerative e like me ka maʻi Parkinson a me Alzheimer.
ʻOiai he mau waiwai pili ka urolithin A a me ka urolithin B, aia kekahi mau ʻokoʻa koʻikoʻi. Eia kekahi laʻana, uaʻikeʻia heʻoi aku ka maikaʻi o ka urolithin A ma keʻano he anti-inflammatory a antioxidant ma mua o ka urolithin B. ʻO Urolithin B, ma kekahiʻaoʻao, uaʻoi aku ka maikaʻi o ka paleʻana i nā pilikia pili i ka momona, e like me ka insulin resistance a me adipocyte. ʻokoʻa.
ʻOkoʻa nā ʻano hana o ka urolithin A a me ka urolithin B. Hoʻoikaika ʻo Urolithin A i ka peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) alahele, e pāʻani ana i kahi hana i ka biogenesis mitochondrial, ʻoiai ʻo urolithin B e hoʻonui i ke ala AMP-activated protein kinase (AMPK), i komo i ka homeostasis ikehu. Hāʻawi kēia mau ala i nā hopena olakino maikaʻi o kēia mau pūhui.
●Nā mea kūʻē i ka ʻāʻī
Ua ʻike ʻia ka ʻāʻī ʻana i nā maʻi he nui. Ua hōʻike ʻia ʻo Urolithin A e loaʻa i nā waiwai anti-inflammatory ikaika, e hōʻemi ana i ka hana ʻana o nā molekole inflammatory. Ma ke kāohi ʻana i ka mumū, hiki iā ia ke kōkua i ka mālama ʻana i nā maʻi maʻi like ʻole e like me ka maʻi ʻāʻī, ka maʻi puʻuwai, a me kekahi mau ʻano maʻi maʻi.
●Ola a me ka ikaika o ka ʻiʻo
I ko mākou mau makahiki, lilo ka nalo ʻana o ka ʻiʻo iwi i mea hopohopo nui. Ua ʻike ʻia ʻo Urolithin A e hoʻoulu i ka ulu ʻana o nā ʻiʻo ʻiʻo a hoʻonui i ka hana ʻiʻo, e hoʻoikaika ana i ke olakino a me ka ikaika. Mālama kēia i ka ʻōlelo hoʻohiki no ka poʻe e ʻimi nei e mālama i ka nui o ka ʻiʻo a me ka hakakā ʻana i ka emi ʻana o ka ʻiʻo pili makahiki.
●Ola Mitochondrial a lōʻihi
Hōʻike ʻo Urolithin A i nā hopena koʻikoʻi ma ka mitochondria, i kapa pinepine ʻia ʻo nā hale mana o kā mākou mau cell. Hoʻomaka ia i kahi kaʻina i kapa ʻia ʻo mitophagy, e pili ana i ka wehe ʻana i ka mitochondria i poino. Ma ka hoʻolaha ʻana i ka hana mitochondrial olakino, hiki i ka urolithin A ke kōkua i ka lōʻihi o ke ola a pale aku i nā kūlana pili makahiki e like me nā maʻi neurodegenerative.
●Hana Antioxidant
ʻO Urolithin B kahi antioxidant ikaika e kōkua i ka pale ʻana i nā radical manuahi ʻino i ke kino. ʻO nā radical manuahi he mau molekole reactive hiki ke kōkua i ka pōʻino cellular a me ke kaumaha oxidative, i hoʻopili ʻia i nā maʻi like ʻole. ʻO ka hana antioxidant a Urolithin B ke kōkua i ka pale ʻana i ko mākou mau sela mai ia pōʻino a hiki ke hōʻemi i ka pilikia o nā maʻi maʻi.
●Ola Ola a me Microbiome Modulation
He mea koʻikoʻi ko mākou ʻōpū i ko mākou olakino holoʻokoʻa, a ua puka mai ka urolithin B ma ke ʻano he mea pāʻani nui i ka mālama ʻana i kahi microbiome ʻōpū olakino. Hoʻoikaika ia i ka ulu ʻana o ka pōmaikaʻicial bacteria a keʻakeʻa i ka ulu ʻana o nā hua bacteria ʻino, pēlā e hoʻoulu ai i kahi ʻano microbial kaulike. Hoʻopili ʻia kahi microbiome gut maikaʻi me ka hoʻomaikaʻi ʻana i ka digestion, ka hana immune, a me ka maikaʻi o ka noʻonoʻo.
●Paipai i ke ola kino
Ua hōʻike ʻia ʻo Urolithin B e hoʻoulu i ka mitochondrial autophagy, kahi kaʻina cellular e kōkua i ka hoʻopau ʻana i ka mitochondria pōʻino mai nā cell. Kōkua kēia kaʻina hana i ka hoʻomaikaʻi ʻana i ke olakino a me ka hana o ka ʻiʻo holoʻokoʻa, e lilo ia i mea hoʻohui kūpono no ka poʻe e ʻimi nei e hoʻomaikaʻi i ka hana kino. Ua ʻike ʻia kahi noiʻi ua hoʻomaikaʻi ʻo urolithin B i ka hana ʻiʻo a me ka ikaika i nā ʻiole a me nā kānaka.
Hana ʻia nā Urolithin i loko o ko mākou kino ma hope o ka ʻai ʻana i kekahi mau meaʻai i loaʻa nā ellagitannins.
a) Pomegerane
ʻO nā pomegerane kekahi o nā kumu meaʻai momona loa o nā ellagitannins, i hoʻololi ʻia i urolithin A a me urolithin B e ka maʻi bacteria. ʻO ka ʻai ʻana i ka hua pomegerane, ka wai, a i ʻole nā mea hoʻoheheʻe hiki ke hoʻonui i kou ʻai ʻana i kēia mau pūhui ikaika, e hoʻomaikaʻi ai i ke olakino cellular a hoʻohana i nā hopena anti-inflammatory.
b) Hua
ʻO nā hua like ʻole e like me nā strawberries, raspberries, a me nā ʻeleʻele i loaʻa nā pae kiʻekiʻe o nā ellagitannins. Ua hōʻike ʻia nā haʻawina ʻo ka ʻai ʻana i kēia mau hua ola e hoʻoikaika i ka hana ʻana o urolithin A a me urolithin B i loko o ka ʻōpū. ʻO ka hoʻohui ʻana i nā huaʻai i kāu meaʻai ʻaʻole e hoʻonui i ka ʻono akā hāʻawi pū kekahi i nā pono olakino lōʻihi.
c) Nati
ʻO nā nati, ʻoi aku ka walnuts a me ka pecans, nā kumu waiwai o nā ellagitannins. Hoʻohui ʻia, hoʻopiha ʻia lākou me nā momona olakino, fiber, a me nā meaʻai pono ʻē aʻe. ʻO ka hoʻokomo ʻana i nā nati i kāu meaʻai i kēlā me kēia lā ʻaʻole wale ka hāʻawi ʻana i ka urolithin A a me B akā hāʻawi pū kekahi i ka nui o nā pono olakino no ka puʻuwai, lolo, a me ka maikaʻi holoʻokoʻa.
d) ʻO nā waina ʻoka
ʻOiai he mea kupanaha paha, hiki i ka ʻai ʻana i ka waina ʻulaʻula oak-aged ke kōkua pū i ka hana urolithin. Hiki ke unuhi ʻia nā mea i loaʻa i loko o nā pahu ʻoka i hoʻohana ʻia i ka wā o ka wā kahiko, e hoʻokomo i ka waina me nā ellagitannins. Eia nō naʻe, he mea nui e hoʻomanaʻo i ka hoʻohana ʻana i ka waiʻona he hopena maikaʻi ʻole i ke olakino, no laila ke kī nui ka hoʻohaʻahaʻa.
e) Nā mea kanu waiwai nui o Ellagitannin
Ma ka ʻaoʻao o nā pomegerane, ua nui maoli kekahi mau mea kanu e like me ka ʻoka ʻoka, nā strawberries, a me nā lau ʻoka i nā ellagitannins. ʻO ka hoʻokomo ʻana i kēia mau mea kanu i kāu meaʻai hiki ke kōkua i ka hoʻonui ʻana i ke kiʻekiʻe o ka urolithin A a me ka urolithin B i loko o kou kino, e kākoʻo ana i ke olakino kelepona a me ka hoʻonui ʻana i ka maikaʻi holoʻokoʻa.
E hoʻokomourolithin A a me B i kou nohona, hoʻokahi ala kūpono ʻo ka ʻai ʻana i nā meaʻai momona i nā ellagitannins. ʻO nā pomegerane, nā strawberries, nā raspberries, a me nā walnuts nā kumu maikaʻi loa.
Eia naʻe, he mea nui e hoʻomaopopo he ʻokoʻa ka ʻike o ka ellagitannin i loko o kēlā me kēia hua, a ʻaʻole i loaʻa i kēlā me kēia kanaka ka microbiota ʻōpū like hiki ke hoʻololi i nā ellagitannins i urolithins. No laila, ʻaʻole hiki i kekahi poʻe ke hana maikaʻi i nā urolithins mai kēia mau kumu meaʻai. ʻO nā mea hoʻohui kahi koho ʻē aʻe e hōʻoia i ka lawe ʻana i ka urolithin A a me B.
Nīnau: Pehea e hoʻoikaika ai ʻo Urolithin A a me Urolithin B i ke olakino mitochondrial?
A: Hoʻoulu ʻo Urolithin A a me Urolithin B i kahi ala kelepona i kapa ʻia ʻo mitophagy, nona ke kuleana no ka wehe ʻana i ka mitochondria pōʻino mai nā cell. Ma ka hoʻolaha ʻana i ka mitophagy, kōkua kēia mau pūhui i ka mālama ʻana i kahi heluna mitochondrial olakino, he mea koʻikoʻi no ka hana ʻana o ka ikehu a me ka hana cellular holoʻokoʻa.
Nīnau: Hiki ke loaʻa iā Urolithin A a me Urolithin B ma o nā mea hoʻohui?
A: ʻAe, loaʻa nā mea hoʻohui Urolithin A a me Urolithin B ma ka mākeke. Eia naʻe, he mea nui e hoʻomaopopo he ʻokoʻa paha ka pono a me ka palekana o kēia mau mea hoʻohui. Manaʻo ʻia e kūkākūkā me kahi ʻoihana mālama ola ma mua o ka hoʻomaka ʻana i nā mea hoʻohui meaʻai hou.
Hoʻokuʻu: ʻO kēia ʻatikala no nā kumu ʻike wale nō a ʻaʻole pono e manaʻo ʻia he ʻōlelo aʻoaʻo olakino. E kamaʻilio mau i kahi ʻoihana mālama ola ma mua o ka hoʻohana ʻana i nā mea hoʻohui a i ʻole ka hoʻololi ʻana i kāu ʻano mālama ola kino.
Ka manawa hoʻouna: Sep-13-2023
