ʻOi aku ka mana o ka taurine ma mua o kou manaʻo!!

I kēia mau lā, ua paʻi ʻia ka noiʻi e pili ana i ka taurine ma nā puke pai ʻekolu kiʻekiʻe ʻo Science, Cell, a me Nature. Ua hōʻike kēia mau haʻawina i nā hana hou o ka taurine - anti-aging, hoʻomaikaʻi i ka hopena o ka mālama ʻana i ka maʻi kanesa, a me ka anti-obesity.

I Iune 2023, ua paʻi nā mea noiʻi mai ka National Institute of Immunology in India, Columbia University ma ʻAmelika Hui Pū ʻIa, a me nā ʻoihana ʻē aʻe i paʻi i nā pepa ma ka puke puke ʻepekema honua kiʻekiʻe. Hōʻike ka haʻawina ʻo ka pau ʻole o ka taurine ke kumu o ka ʻelemakule. Hiki i ka hoʻohui ʻana i ka taurine ke hoʻolōʻihi i ka ʻelemakule o nā nematodes, nā ʻiole, a me nā monkey, a hiki ke hoʻonui i ke ola olakino o nā ʻiole waena ma 12%. Nā kikoʻī: ʻepekema: Mana ma mua o kou manaʻo! Hiki i ka Taurine ke hoʻohuli i ka wā kahiko a hoʻonui i ke ola?

I ʻApelila 2024, ua paʻi ʻo Polofesa Zhao Xiaodi, Luna Hoʻokele ʻo Lu Yuanyuan, Polofesa Nie Yongzhan, a me Profesor Wang Xin mai ka Halemai Xijing o ka ʻEhā Military Medical University i paʻi i nā pepa ma ka puke moʻolelo hoʻonaʻauao honua kiʻekiʻe. Ua ʻike ʻia kēia haʻawina e hoʻokūkū ana nā cell tumor me nā cell CD8 + T no ka taurine ma o ka hoʻohālikelike ʻana i ka mea transporter taurine SLC6A6, ka mea e hoʻoulu ai i ka make a me ka luhi o ka cell T, e alakaʻi ana i ka pakele ʻana o ka maʻi maʻi, a laila e hoʻoikaika i ka piʻi ʻana a me ka hoʻi hou ʻana, ʻoiai ke hoʻohui ʻana i ka Taurine hiki ke hoʻāla hou i nā cell CD8 + T pau. a hoʻomaikaʻi i ka maikaʻi o ka mālama ʻana i ka maʻi kanesa.

Ma ʻAukake 7, 2024, ua paʻi ka hui o Jonathan Z. Long o ke Kulanui ʻo Stanford (ʻo Kauka Wei Wei ka mea kākau mua) i kahi pepa noiʻi i kapa ʻia ʻo: PTER he N-acetyl taurine hydrolase e hoʻoponopono ana i ka hānai ʻana a me ka momona ma nā kula honua kiʻekiʻe. puke pai Nature.

Ua ʻike kēia haʻawina i ka N-acetyl taurine hydrolase mua i nā mammals, PTER, a ua hōʻoia i ka hana nui o N-acetyl taurine i ka hōʻemi ʻana i ka ʻai a me ka anti-obesity. I ka wā e hiki mai ana, hiki ke hoʻomohala i nā mea paʻa PTER ikaika a koho no ka mālama ʻana i ka momona.

Loaʻa nui ʻia ka Taurine i loko o nā ʻiʻo mammalian a me nā meaʻai he nui a loaʻa i nā ʻano kiʻekiʻe kiʻekiʻe i nā ʻiʻo hoihoi e like me ka puʻuwai, nā maka, ka lolo, a me nā ʻiʻo. Ua wehewehe ʻia ʻo Taurine e loaʻa i ka pleiotropic cellular a me nā hana physiological, ʻoi loa i ka pōʻaiapili o ka homeostasis metabolic. ʻO ka hoʻohaʻahaʻa genetic i nā pae taurine e alakaʻi i ka atrophy o ka ʻiʻo, hoʻemi i ka hiki ke hoʻoikaika kino, a me ka dysfunction mitochondrial i nā ʻiʻo he nui. ʻO ka hoʻonui ʻana o Taurine e hoʻemi i ke koʻikoʻi mitochondrial redox, hoʻomaikaʻi i ka hiki ke hoʻoikaika, a hoʻopau i ke kaumaha o ke kino.

ʻO ka biochemistry a me ka enzymology o ka taurine metabolism ua hoihoi nui i ka noiʻi noiʻi. Ma ke ala o ka biosynthetic taurine endogenous, ua hoʻopili ʻia ka cysteine ​​​​e ka cysteine ​​​​dioxygenase (CDO) a me ka cysteine ​​​​sulfinate decarboxylase (CSAD) e hoʻohua i ka hypotaurine, ʻo ia hoʻi ka Oxidation e flavin monooxygenase 1 (FMO1) e hoʻohua ai i ka taurine. Eia kekahi, hiki i ka cysteine ​​​​ke hana i ka hypotaurine ma o ke ala ʻē aʻe o cysteamine a me cysteamine dioxygenase (ADO). Aia ma lalo iho o ka taurine iho kekahi mau metabolites taurine lua, me ka taurocholate, tauramidine, a me N-acetyl taurine. ʻO ka enzyme wale nō i ʻike ʻia e hoʻolalelale i kēia mau ala i lalo ʻo BAAT, ka mea e hui pū ai i ka taurine me ka bile acyl-CoA e hana i ka taurocholate a me nā paʻakai bile ʻē aʻe. Ma waho aʻe o ka BAAT, ʻaʻole i hoʻoholo ʻia ka ʻike molekala o nā enzyme ʻē aʻe e hoʻopaʻa nei i ka metabolism taurine lua.

ʻO ka N-acetyltaurine (N-acetyl taurine) he mea hoihoi loa ia akā ʻaʻole i aʻo maikaʻi ʻia ka metabolite lua o ka taurine. Hoʻoponopono ikaika ʻia nā pae N-acetyl taurine i loko o nā wai ola e nā pilikia physiological he nui e hoʻonui ai i ka taurine a / a i ʻole acetate flux, me ka hoʻomaʻamaʻa hoʻomanawanui, ka inu ʻawaʻawa, a me ka hoʻonui ʻana i ka taurine. Hoʻohui ʻia, loaʻa ka N-acetyltaurine i nā ʻano like ʻole me ka hōʻailona ʻana i nā molekole me ka neurotransmitter acetylcholine a me ka kaulahao lōʻihi N-fatty acyltaurine e hoʻoponopono ai i ke kō koko, e manaʻo ana e hana pū ia ma ke ʻano he metabolite hōʻailona. Eia naʻe, ʻaʻole maopopo ka biosynthesis, degradation, a me nā hana kūpono o N-acetyl taurine.

Ma kēia noiʻi hou loa, ua ʻike ka hui noiʻi i ka PTER, kahi enzyme makua ʻole o ka hana ʻike ʻole, ʻo ia ka mammalian N-acetyl taurine hydrolase. In vitro, hōʻike ʻo PTER recombinant i kahi ākea substrate a me nā palena nui. I loko o N-acetyl taurine, ua hydrolyzed ia i taurine a me ka acetate.

ʻO ke kīkēkē ʻana i ka gene Pter i nā ʻiole ka hopena i ka nalowale piha ʻana o ka hana hydrolytic N-acetyl taurine i loko o nā ʻiʻo a me ka hoʻonui ʻana o ka N-acetyl taurine i loko o nā ʻāpana like ʻole.

Hoʻopili ʻia ka wahi PTER kanaka me ka helu kino kino (BMI). Ua ʻike hou ka hui noiʻi ma hope o ka hoʻoulu ʻana me ka piʻi ʻana o nā pae taurine, ua hōʻike ʻo Pter knockout mice i ka hoʻemi ʻana i ka ʻai ʻana i ka meaʻai a kūʻē i ka momona i hoʻokomo ʻia i ka meaʻai. a hoʻomaikaʻi i ka homeostasis glucose. ʻO ka hoʻohui ʻana o N-acetyl taurine i nā ʻiole ʻano ʻāhiu momona i hoʻemi ʻia ka ʻai a me ke kaumaha o ke kino ma kahi ʻano hilinaʻi GFRAL.

Hoʻokomo kēia mau ʻikepili i ka PTER ma ke kumu enzyme node o ka taurine secondary metabolism a hōʻike i nā kuleana o PTER a me N-acetyl taurine i ka hoʻokele paona a me ke koena o ka ikehu.

Ma keʻano holoʻokoʻa, ua ʻike kēia haʻawina i ka acetyl taurine hydrolase mua i nā mammals, PTER, a ua hōʻoia i ka hana nui o ka acetyl taurine i ka hōʻemi ʻana i ka ʻai a me ka anti-obesity. I ka wā e hiki mai ana, ua manaʻo ʻia e hoʻomohala ʻia nā mea paʻa PTER ikaika a koho no ka mālama ʻana i ka momona.