Pehea e hiki ai i ka Glycerylphosphocholine ke hoʻonui i kou mana lolo?

Glycerylphosphocholine (GPC, i kapa ʻia ʻo L-alpha-glycerylphosphorylcholine a i ʻole alphacholine)He kumu maoli ia o ka choline i loaʻa i loko o nā ʻano meaʻai like ʻole (me ka waiū umauma) a i loko o nā pūnaewele kanaka a pau Loaʻa i ka choline liʻiliʻi. ʻO GPC kahi mole e hiki ke hoʻoheheʻe ʻia i ka wai i hōʻike ʻia he kumu ʻoi aku ka ikaika o ka choline maʻi ma mua o ka choline a i ʻole phosphatidylcholine (PC) mai ka meaʻai a i ʻole nā ​​​​mea hoʻohui.

Hoʻopili maikaʻi ʻia ka GPC i hāʻawi ʻia ma ka waha a ua ʻoki ʻia i loko o nā enterocytes i glycerol-1-phosphate a me choline. Ma hope o ka ʻai ʻana i ka GPC, piʻi wikiwiki nā pae koho i loko o ka plasma a noho kiʻekiʻe no 10 mau hola. ʻO ka gradient plasma kiʻekiʻe o ka choline e hoʻoulu i kāna lawe pono ʻana ma waena o ka pale koko-lolo. Hoʻonui kēia i nā hale kūʻai choline i loko o nā neurons, kahi i hoʻohana ʻia e synthesize PC a me acetylcholine.

Ma ke ʻano, ʻo ka α-GPC kahi pūhui choline i hoʻopaʻa ʻia i kahi mole glycerol ma o kahi hui phosphate, a he choline i loko o ka phospholipid. He kiʻekiʻe loa ka ʻike o ka choline, e pili ana i ka 40%, ʻo ia ka 1000 mg o α-GPC hiki ke hana i kahi 400 mg o ka choline manuahi.

ʻO Choline kahi meaʻai nui i loaʻa i nā huahana waiū a me nā hua manu e kōkua i nā cell e mālama i ko lākou mau membrane. Pono nō hoʻi ʻo Choline e hana i ka acetylcholine. ʻOiai hiki i ka alpha-GPC a me nā koho ʻē aʻe e like me ka phosphatidylcholine a me ka lecithin ke hoʻoikaika i ka hana ʻana o ka acetylcholine, ʻoi aku ka maikaʻi o ka alpha-GPC no ka mea ʻo nā lipid i hāʻawi ʻia e maʻalahi i nā cell e komo, ʻoi aku ma mua o 90% o ka phosphatidylcholine e komo i nā moku lymphatic. , ʻoiai ʻo ka α-GPC ka hapa nui o ka vein portal, no laila ʻoi aku ka kiʻekiʻe o ka absorption efficiency, no laila e hoʻoikaika maikaʻi i ka hana ʻana o ka acetylcholine. ʻO ka Acetylcholine kahi neurotransmitter e hana nui i ka hoʻoponopono ʻana i ka hana o ka lolo a me ka hoʻomalu ʻana i ka ʻiʻo. ʻOiai hiki iā mākou ke ʻai i ka choline ma o ka meaʻai, e emi ana ka nui o ka acetylcholine me ka makahiki.

Nā Pōmaikaʻi o ka GPC ma muli o ka noiʻi

Hana lolo

• Hoʻomaikaʻi i ka hoʻomanaʻo, ka noʻonoʻo a me ka manawa pane i nā poʻe ʻelemakule a ʻōpio
• Hoʻoikaika i ka hana a me ka hoʻokuʻu ʻana o ka acetylcholine (ACh) mai nā neurons a me nā mea ʻē aʻe paha.
• Hiki ke hoʻopaʻi no ka emi ʻana o ka ACh ma muli o ka ʻelemakule, ka nele o ka estrogen (ka menopause, a me ka hoʻohana ʻana paha i ka hoʻohana ʻana i ka waha)
• Hoʻomaikaʻi i nā hiʻohiʻona EEG
• Hoʻonui i ka hana o dopamine, serotonin a me GABA18.
• Hoʻomaikaʻi i ka hana mitochondrial i ka wā ischemia / oxidative stress
• Hoʻohālikelike i ka emi ʻana o ka makahiki i loko o ka lolo lolo a me ka helu ACh receptor, ka hana ʻiʻo a me ka ulu ʻana o ka hormone ulu
• Hoʻoikaika i ka ulu ʻana o ka hormone ulu i nā ʻōpio a me nā ʻelemakule
• Hoʻonui i ka momona momona, ka ikaika o ka ʻiʻo a me ka manawa pane, hiki paha ke hoʻomaikaʻi i ke kaulike, ʻoi aku ka nui o ka poʻe ʻelemakule.

Hoʻoponopono i ka lolo a me ke kākoʻo ʻana o Alzheimer/Dementia

• Hoʻomaikaʻi i ka hoʻihoʻi ʻana o ka lolo ma hope o ka hahau ʻana, ka ʻeha lolo, a me ka anesthesia (ma mua a ma hope o ke ʻoki ʻana).
• Hoʻoponopono i ka ʻiʻo pale koko-lolo i hōʻino ʻia e ka hypertension
• Hoʻomaikaʻi i ka ʻike a me ka nohona pili kanaka i ka maʻi o Alzheimer, ka dementia vascular/senile, a me ka maʻi Parkinson.
• E hoemi i ka nui o ka lolo e like me ka ma'i o Alzheimer
• Pono paha i nā maʻi e pono ai ka hoʻoponopono ʻana i ka myelin a me ka Duchenne muscular dystrophy Nā hana Choline i ka metabolism kanaka a me ka GPC

ʻO nā waiwai kūʻokoʻa ma ke ʻano he kumu ikaika o ka choline, ka hale kūkulu o ka acetylcholine a me kahi mea e hoʻoulu ai i kāna synthesis a me ka huna.

• ʻO ka Acetylcholine he mea hoʻoneʻe i loko o ka lolo a me ka transducer hōʻailona ma nā wahi ʻē aʻe o ke kino, koʻikoʻi no ka ʻoki ʻana o ka ʻiʻo, ka ʻili o ka ʻili, ka motility gastrointestinal, a me nā hana ʻē aʻe. ʻAʻole like me ka choline / PC i hāʻawi ʻia ma o ka meaʻai a i ʻole supplementation, ua hōʻike ʻia ka hoʻonui ʻana o GPC i kahi hopena hoʻoulu nui i ka synthesis o ACh a me kona hoʻokuʻu ʻana mai nā cell cholinergic.

ʻO ka hoʻohui ʻana o ka GPC ka hopena i ka hōʻailona cholinergic i hoʻonui ʻia i nā neurons a me nā mea ʻē aʻe e hana ai i ka acetylcholine. He mea maikaʻi loa kēia ke hoʻemi ʻia ka helu a me ka hana pono o nā neurons cholinergic ma muli o ka ʻelemakule maʻamau a i ʻole nā ​​​​kaʻina degenerative like ʻole. Hiki i ka hoʻohui ʻana me GPC ke hoʻopaʻi hapa no kēia mau hemahema no ka mea e piʻi wikiwiki ana ka choline plasma, e hoʻokau i kahi hopena substrate ikaika i nā enzymes a me nā mea lawe i kēia mau ala.

Ke kūkulu hale o phosphatidylcholine (PC)

• No nā phospholipids ka PC a he mea nui ia o nā membrane cell a me nā membrane mitochondrial. ʻO ka hiki i ka GPC supplementation ke kōkua i ka hoʻihoʻi hou ʻana o ka hahau, a me ka pale ʻana i ka emi ʻana o ka makahiki i ka helu o nā mea hoʻokipa ACh i loko o nā pūnana nerve a i ʻole lolo, he hōʻike hou ia o kāna hāʻawi ʻana i ka mālama ʻana i ka membrane neuronal ma o PC synthesis.

Hoʻokumu ʻia o sphingomyelin

• 'O ka sphingomyelin he mea ia o ka myelin sheath e uhi ana a ho'opa'a i nā neurons a me nā a'alolo. No laila, hiki ke hoʻohana ʻia ka GPC supplementation i kēlā me kēia kūlana me ka hoʻonui ʻana i ka noi no ka hoʻoponopono ʻana i ka myelin, e like me ka neuropathy, multiple sclerosis, a me nā kūlana ʻē aʻe e pili ana i ka demyelination a me ka autoimmunity o ke kino nerve. ʻO ka lawe ʻana i ka momona i loko a i waho

• Pono ka PC no ka synthesis a me ka huna ʻana o nā ʻāpana VLDL. Haʻalele ʻo Triglycerides i ke akepaʻa i loko o nā ʻāpana VLDL, e wehewehe ana i ke kumu e hoʻonui ai ka hemahema o ka choline i ka maʻi o ka maʻi ate. Hiki ke loaʻa ka PC mai nā kumu meaʻai a i ʻole nā ​​mea hoʻohui; akā naʻe, ʻaʻole i loaʻa pololei ʻia ka PC no nā phospholipids a me nā lipoproteins mai ka PC i hoʻokomo ʻia a i hana mua ʻia. Hoʻopili ʻia ia mai nā koho koho mua (me ka GPC), no laila ʻaʻole pono ka hoʻohana ʻana i ka PC ke ala maikaʻi loa e hoʻonui ai i ka kolamu PC o ke kino.
Kākoʻo i ka motility sperm

• He kumu nui ka GPC i ka hoʻopili ʻana o DHA (docosahexaenoic acid), e hana ana i ka PC-DHA. Hoʻohana ʻia ka paʻakikī DHA-PC i nā ʻano kelepona ikaika loa e like me ka retinal light-sensing cell a me sperm cell. Hoʻonui ka DHA-PC i ka wai o ka membrane, he mea koʻikoʻi no ka hana sperm olakino. Loaʻa i ka Semen nā kiʻekiʻe o ka GPC; ʻO nā pūnaewele epididymal e hoʻoulu ana i nā pūnana sperm i unuhi ʻia mai ka loko GPC a hoʻohui i ka PC-DHA. ʻO nā haʻahaʻa haʻahaʻa o GPC a me PC-DHA i loko o ka semen hiki ke hoʻonui i ka pilikia o ka emi ʻana o ka motility sperm.

Hoʻohālikelike o GPC a me Acetyl-L-Carnitine (ALCAR)

• Ma ke aʻo ʻana i nā poʻe maʻi me ka maʻi Alzheimer kiʻekiʻe, ua loaʻa i ka GPC ka hoʻomaikaʻi ʻana i ka hapa nui o nā ʻāpana neuropsychological i hoʻohālikelike ʻia me ALCAR. ʻOiai ke kākoʻo nei nā pūhui ʻelua i ka hoʻonui ʻana i ka acetylcholine, hiki ke noʻonoʻo ʻia he hopena synergistic ma waena o ka hoʻohui ʻana i nā pūhui ʻelua, no ka mea, hāʻawi ʻo GPC i ka choline aʻo ALCAR e hāʻawi i ka acetyl component no ka synthesis o acetylcholine.

ʻO ka synergy kūpono ma waena o GPC a me nā lāʻau lapaʻau. ʻAʻole manaʻo ʻia ʻo GPC supplementation e hoʻopilikia maikaʻi i nā lāʻau i hoʻolālā ʻia e hoʻomaikaʻi i ka hana o ka lolo. ʻO ka ʻoiaʻiʻo, ma muli o kāna mau pōmaikaʻi ma nā ala cholinergic a me ka hoʻomaikaʻi ʻana i ka hana membrane cell neuronal, hiki ke hoʻonui i kā lākou mau pono. Hiki i ka GPC ke hoʻonui i nā hopena o ka acetylcholinesterase AChE inhibitors no ka mea hiki ke hoʻonui i ka nui o ka ACh i loko o ka synaptic cleft, akā e hoʻolōʻihi kēia mau lāʻau i kona hōʻino ʻana.

Eia kekahi, e like me nā haʻawina holoholona, ​​hiki i ka GPC ke hoʻonui i ka hana o dopamine, serotonin, a i ʻole GABA i ka lolo, a hiki i ka GPC ke hoʻonui i nā hopena o ka reuptake inhibitors o kēia mau neurotransmitters.

ʻO Suzhou Myland Pharm & Nutrition Inc. he mea hana i kākau inoa ʻia e FDA e hāʻawi ana i ka pauka Alpha GPC kiʻekiʻe a maʻemaʻe.

Ma Suzhou Myland Pharm mākou e hoʻolako i nā huahana kiʻekiʻe loa i nā kumukūʻai maikaʻi loa. ʻO kā mākou Alpha GPC pauka i ho'āʻo ikaikaʻia no ka maʻemaʻe a me ka ikaika, e hōʻoiaʻiʻo ana e loaʻa iāʻoe kahi mea hoʻopihapiha kiʻekiʻe e hiki iāʻoe ke hilinaʻi. Inā makemake ʻoe e kākoʻo i ke olakino cellular, hoʻonui i kāu ʻōnaehana pale a hoʻonui i ke olakino holoʻokoʻa, ʻo kā mākou Alpha GPC pauka ke koho maikaʻi loa.

Me 30 mau makahiki o ka ʻike a alakaʻi ʻia e ka ʻenehana kiʻekiʻe a me nā hoʻolālā R&D maikaʻi loa, ua hoʻomohala ʻo Suzhou Myland Pharm i nā ʻano huahana hoʻokūkū a lilo i mea hoʻohui ʻepekema ola hou, synthesis maʻamau a me nā ʻoihana lawelawe hana.

Eia kekahi, ʻo Suzhou Myland Pharm kekahi mea hana inoa FDA. ʻO nā kumuwaiwai R&D o ka hui, nā lako hana, a me nā mea hana analytical he mea hou a multifunctional, a hiki ke hana i nā kemika mai ka milligrams a hiki i nā tona i ka unahi, a hoʻokō i nā kūlana ISO 9001 a me nā kikoʻī hana GMP.