Ma ke ʻano o ke olakino a me ka maikaʻi, ʻo ka ʻimi ʻana i ka lōʻihi a me ka ikaika i alakaʻi i ka ʻimi ʻana i nā ʻano mea like ʻole a me nā pono kūpono. ʻO kekahi o ia pūhui i ulu nui ʻia i nā makahiki i hala iho nei, ʻo ia ka urolithin A. No ka ellagic acid, ʻo ka urolithin A he metabolite i hana ʻia e ka ʻōpū microbiota ma hope o ka ʻai ʻana i kekahi mau meaʻai, e like me nā pomegerane, nā strawberries, a me nā raspberry.
ʻO Urolithin A (Uro-A) kahi ʻano ellagitannin-type flora metabolite. ʻO C13H8O4 kona ʻano mole mole a ʻo ka nuipaʻa molekika pili he 228.2. E like me ka metabolic precursor o Uro-A, nā kumu meaʻai nui o ET he pomegerane, strawberries, raspberries, walnuts a me ka waina ʻulaʻula. ʻO ka UA kahi huahana o nā ET i hoʻololi ʻia e nā microorganisms ʻōpū. I nā makahiki i hala iho nei, me ka hoʻomohala ʻana o ka noiʻi, ua ʻike ʻia he kuleana pale ka Uro-A i nā maʻi maʻi like ʻole (e like me ka maʻi maʻi umauma, ka maʻi maʻi endometrial a me ka prostate), nā maʻi cardiovascular a me nā maʻi ʻē aʻe.
Ma muli o kona hopena anti-inflammatory ikaika, hiki i ka UA ke pale i nā puʻupaʻa a pale i nā maʻi e like me ka colitis, osteoarthritis, a me ka degeneration disc intervertebral. Ma ka manawa like, ua ʻike nā haʻawina he pono ka UA i ka mālama ʻana i nā maʻi neurodegenerative me ka maʻi Alzheimer a me ka maʻi Parkinson. he hopena koʻikoʻi. Eia kekahi, he hopena maikaʻi ka UA i ka pale ʻana a me ka mālama ʻana i nā maʻi metabolic he nui. Loaʻa iā UA nā manaʻo hoʻohana ākea i ka pale ʻana a me ka mālama ʻana i nā maʻi he nui. I ka manawa like, he nui nā kumu meaʻai o UA.
Ua hana ʻia ka noiʻi e pili ana i nā hopena antioxidant o nā urolithins. ʻAʻole ʻo Urolithin-A i loko o ke ʻano kūlohelohe, akā hana ʻia e nā ʻano hoʻololi o ET e ka flora intestinal. ʻO ka UA kahi huahana o nā ET i hoʻololi ʻia e nā microorganisms ʻōpū. ʻO nā meaʻai momona i ka ET e hele i loko o ka ʻōpū a me ka ʻōpū liʻiliʻi i loko o ke kino o ke kanaka, a hoʻololi ʻia i loko o ka Uro-A i loko o ke kolonā. Hiki ke ʻike ʻia kahi helu liʻiliʻi o Uro-A ma ka ʻōpū liʻiliʻi haʻahaʻa.
Ma ke ʻano he pūhui polyphenolic maoli, ua ʻike nui ʻia nā ET ma muli o kā lākou mau hana olaola e like me antioxidant, anti-inflammatory, anti-allergic and anti-viral. Ma waho aʻe o ka loaʻa ʻana mai o nā meaʻai e like me nā pomegerane, strawberries, walnuts, raspberries, a me nā ʻalemona, loaʻa pū nā ETs i nā lāʻau lapaʻau kuʻuna Kina e like me ka gallnuts, peels pomegranate, a me ka agrimony. ʻO ka hui hydroxyl i loko o ka molecular structure o ETs he polar, ʻaʻole kūpono i ka absorption e ka paia ʻōpū, a haʻahaʻa loa kona bioavailability.
Ua ʻike ʻia nā haʻawina he nui ma hope o ka ʻai ʻia ʻana o nā ET e ke kino o ke kanaka, ua hoʻololi ʻia lākou e nā pua ʻōpū i loko o ke kolonā a hoʻololi ʻia i urolithin ma mua o ka lawe ʻia ʻana. Hoʻoheheʻe ʻia nā ETs i loko o ka waikawa ellagic i loko o ka ʻōpū o ka ʻōpū o luna, a ua hana hou ʻia ʻo EA e nā pua ʻōpū a nalowale hoʻokahi. Aia nā hōʻike e hiki i ka urolithin ke kumu waiwai no nā hopena olaola o ET i ke kino.
Urolithin A a me ke Ola Mitochondrial
ʻO kekahi o nā mea hoihoi loa o ka urolithin A ʻo kona hopena i ke olakino mitochondrial. Ua kapa ʻia ʻo Mitochondria ma ke ʻano he mana o ke kelepona, e pāʻani ana i kahi kuleana koʻikoʻi i ka hana ʻana o ka ikehu a me ka hana cellular. I ko mākou mau makahiki, hiki ke emi i ka hana o kā mākou mitochondria, e alakaʻi ana i nā pilikia olakino pili i ka makahiki. Ua hōʻike ʻia ʻo Urolithin A e hoʻolaʻa hou i ka mitochondria dysfunctional ma o kahi kaʻina i kapa ʻia ʻo mitophagy, e pili ana i ka wehe ʻana i ka mitochondria i poino a me ka hoʻolaha ʻana i ka hana mitochondrial olakino. Hiki i kēia rejuvenation o mitochondria ke hoʻonui i ka pae o ka ikehu holoʻokoʻa, hoʻoikaika i ke olakino cellular, a kākoʻo i ka lōʻihi.
Ola kino a me ka hana
Ma waho aʻe o kona hopena i ke olakino mitochondrial, ua hoʻopili pū ʻia ka urolithin A i ka hoʻomaikaʻi ʻana i ke olakino a me ka hana. Ua hōʻike nā haʻawina e hiki i ka urolithin A ke hoʻoulu i ka hana ʻana o nā ʻiʻo ʻiʻo hou a hoʻonui i ka hana ʻiʻo. He mea koʻikoʻi kēia no nā poʻe e ʻimi nei e mālama i ka nui o ka ʻiʻo a me ka ikaika i ko lākou mau makahiki, a me nā mea pāʻani e ʻimi nei e hoʻokō i kā lākou hana. ʻO ka hiki o ka urolithin A ke kākoʻo i ke olakino a me ka hana o ka ʻiʻo he hopena koʻikoʻi no ka maikaʻi o ke kino holoʻokoʻa a me ka maikaʻi o ke ola.
ʻO nā waiwai Anti-Inflammatory a me Antioxidant
Ua ʻike ʻia ʻo Urolithin A no kāna mau waiwai anti-inflammatory a me antioxidant. ʻO ka maʻi ʻeha a me ke koʻikoʻi oxidative nā kumu kumu i ka ulu ʻana o nā maʻi maʻi he nui, e like me ka maʻi cardiovascular, neurodegenerative disorders, a me kekahi mau ʻano o ka maʻi kanesa. Ua hōʻike ʻia ʻo Urolithin A e hoʻololi i nā ala inflammatory a hōʻemi i ka pōʻino oxidative, a laila e hana i nā hopena pale i kēia mau kaʻina hana ʻino. Ma ka ho'ēmiʻana i ka mumū a me ke kaumaha oxidative, hiki i ka urolithin A ke kōkua i ka pale a me ka mālamaʻana i nā maʻi likeʻole e pili ana i ka makahiki a me ke ola.
Hana noʻonoʻo a me ke ola lolo
ʻO ka hopena o ka urolithin A ʻoi aku ma mua o ke olakino kino, ʻoiai ʻo ka noiʻi e puka mai nei e hōʻike ana i kāna mau pono kūpono no ka hana cognitive a me ke olakino lolo. Hōʻike ʻia nā kūlana neurodegenerative, e like me ka maʻi Alzheimer, e ka hōʻiliʻili ʻana o nā protein abnormal a me ka hana cellular impaired i ka lolo. Ua hōʻike ʻo Urolithin A i nā hopena neuroprotective, me ka hoʻomaʻemaʻe ʻana i nā protein toxic a me ka hoʻoikaika ʻana i ka neʻe ʻana o ka neuronal. Loaʻa kēia mau ʻike i ka ʻōlelo hoʻohiki no ka hoʻohana ʻana o ka urolithin A i ke kākoʻo ʻana i ke olakino lolo a me ka hana cognitive, e hāʻawi ana i kahi ala hou no ka hoʻoponopono ʻana i ka emi ʻana o ka cognitive pili i ka makahiki a me nā maʻi neurodegenerative.
ʻO ke ola kino a me ke olakino Metabolic
He kuleana koʻikoʻi ka gut microbiota i ke olakino kanaka, e hoʻohuli ana i nā kaʻina physiological like ʻole, me ka metabolism a me ka hana immune. ʻO Urolithin A, ma ke ʻano he huahana o ka microbial metabolism, ua pili pū me nā hopena maikaʻi i ke olakino ʻōpū a me ka olakino metabolic. Ua hōʻike ʻia e hāpai i ka ulu ʻana o nā hua bacteria maikaʻi i ka ʻōpū, hoʻololi i nā ala metabolic, a hoʻomaikaʻi i ka ʻike insulin. Loaʻa kēia mau hopena i nā hopena no ka mālama ʻana i nā maʻi metabolic, e like me ka momona a me ka maʻi diabetes type 2, e hōʻike ana i ka hiki o ka urolithin A ma ke ʻano he ala kūlohelohe e kākoʻo ai i ke olakino metabolic.
ʻO ka wā e hiki mai ana o Urolithin A: Nā hopena no ke olakino a me ka maikaʻi
Ke hoʻomau nei ka noiʻi ʻana e pili ana i ka urolithin A, ʻike nui ʻia kona hopena i ke olakino a me ka maikaʻi. Mai kona hopena i ka mitochondrial rejuvenation a me ke ola kino a hiki i kona anti-inflammatory, antioxidant, a me neuroprotective properties, urolithin A e hōʻike ana i kahi mea hoʻololi pāʻani i ka ʻimi ʻana i ka lōʻihi a me ka ikaika. ʻO ka manaʻolana o ka hoʻohana ʻana i nā pono o ka urolithin A ma o nā kumu meaʻai a i ʻole supplementation e paʻa i ka ʻōlelo hoʻohiki no ka hoʻoponopono ʻana i ka nui o nā pilikia olakino a me ka hoʻomaikaʻi ʻana i ka maikaʻi holoʻokoʻa.
Ua loaʻa i ka Urolithin A ka manaʻo i nā makahiki i hala iho nei no kāna mau pono olakino olakino, ʻoi aku hoʻi ma ke ʻano o ke olakino kelepona a me ka lōʻihi. Loaʻa kēia pūhui kūlohelohe mai ka ellagic acid, i loaʻa i kekahi mau huaʻai a me nā nati. ʻOiai makemake paha ka poʻe he nui i ka hoʻokomo ʻana i ka urolithin A i loko o kā lākou hana olakino, he mea nui ia e hoʻomaopopo ʻaʻole kūpono ia no kēlā me kēia. Ma kēia blog, e ʻimi mākou i ka mea e pale aku i ka lawe ʻana i ka urolithin A a no ke aha.
Ka manawa hoʻouna: Iulai-30-2024
