Me ka hoʻomohala ʻana o ke kaiāulu, ke nānā nui nei nā kānaka i nā pilikia olakino. I kēia lā, makemake wau e hoʻolauna iā ʻoe i kekahi ʻike e pili ana i ka maʻi o Alzheimer, kahi maʻi lolo holomua e hoʻopau ai i ka hoʻomanaʻo a me nā ʻike naʻauao ʻē aʻe.
ʻOiaʻiʻo
ʻO ka maʻi o Alzheimer, ke ʻano maʻamau o ka dementia, he huaʻōlelo maʻamau no ka hoʻomanaʻo a me ka nalowale o ka naʻauao.
ʻO ka maʻi o Alzheimer he mea make a ʻaʻohe mea e ola ai. He maʻi hoʻomau ia e hoʻomaka ana me ka nalowale o ka hoʻomanaʻo ʻana a hiki i ka pōʻino lolo.
Ua kapa ʻia ka maʻi ma muli o Kauka Alois Alzheimer. I ka makahiki 1906, ua hana ka neuropathologist i kahi autopsy ma ka lolo o kahi wahine i make ma hope o ka hoʻomohala ʻana i ka haʻi ʻōlelo, ka hana hiki ʻole a me ka nalowale hoʻomanaʻo. Ua ʻike ʻo Kauka Alzheimer i nā pāpaʻi amyloid a me nā kuʻi neurofibrillary, i manaʻo ʻia he mau hōʻailona o ka maʻi.
Nā mea hoʻoikaika:
Makahiki – Ma hope o ka makahiki 65, e pāpālua ka maʻi o Alzheimer i kēlā me kēia ʻelima makahiki. No ka hapanui o nā kānaka, ʻike mua ʻia nā hōʻailona ma hope o ke 60 makahiki.
Moʻolelo ʻohana – He kuleana ko nā kumu genetic i ka pilikia o ke kanaka.
ʻEha Poʻo - Aia paha kahi loulou ma waena o kēia maʻi a me ka ʻeha pinepine a i ʻole ka nalowale o ka ʻike.
ʻO ke ola o ka naʻau - ʻO ka maʻi puʻuwai e like me ke koko kiʻekiʻe, ka cholesterol kiʻekiʻe a me ka maʻi diabetes hiki ke hoʻonui i ka pilikia o ka dementia vascular.
He aha nā hōʻailona hōʻailona 5 o ka maʻi o Alzheimer?
ʻO nā hōʻailona hiki ke hiki: nalowale ka hoʻomanaʻo, ka hana hou ʻana i nā nīnau a me nā ʻōlelo, ka hoʻopaʻapaʻa impaired, misplacement item, naʻau a me nā loli o ke ʻano, huikau, hoʻopunipuni a me ka paranoia, impulsivity, hopu, paʻakikī ke ale.
He aha ka ʻokoʻa ma waena o ka dementia a me ka maʻi o Alzheimer?
ʻO ka Dementia a me ka maʻi Alzheimer nā maʻi ʻelua e pili ana i ka emi ʻana o ka cognitive, akā aia kekahi mau ʻokoʻa ma waena o lākou.
ʻO ka Dementia kahi maʻi e pili ana i ka emi ʻana o ka hana cognitive i hoʻokumu ʻia e nā kumu he nui, me nā hōʻailona e like me ka nalowale o ka hoʻomanaʻo, hoʻemi ʻia ka noʻonoʻo, a me ka hoʻoholo ʻana. ʻO ka maʻi o Alzheimer ke ʻano maʻamau o ka dementia a ʻo ia ka helu no ka hapa nui o nā hihia dementia.
ʻO ka maʻi o Alzheimer kahi maʻi neurodegenerative holomua e hahau pinepine i ka poʻe ʻelemakule a ʻike ʻia e ka waiho ʻana o ka protein i loko o ka lolo, e alakaʻi ana i ka pōʻino neuronal a me ka make. ʻO ka Dementia kahi huaʻōlelo ākea e pili ana i ka emi ʻana o ka cognitive i hoʻokumu ʻia e nā kumu like ʻole, ʻaʻole wale ka maʻi Alzheimer.
Nā kuhi aupuni
Manaʻo nā Centers for Disease Control and Prevention ma kahi o 6.5 miliona ʻAmelika i loaʻa i ka maʻi Alzheimer. ʻO ka maʻi ka ʻelima kumu nui o ka make i nā pākeke ma luna o 65 ma ʻAmelika Hui Pū ʻIa.
ʻO ke kumukūʻai o ka mālama ʻana i ka poʻe me ka maʻi Alzheimer a i ʻole nā dementia ʻē aʻe ma ʻAmelika Hui Pū ʻIa i manaʻo ʻia he $345 biliona i 2023.
ʻo ka hoʻomaka ʻana o ka maʻi Alzheimer
ʻO ka maʻi o Alzheimer i hoʻomaka mua ʻia he ʻano kakaikahi o ka dementia e pili ana i ka poʻe ma lalo o 65 mau makahiki.
ʻO ka maʻi o Alzheimer i hoʻomaka mua e holo pinepine i nā ʻohana.
Ka noiʻi
Malaki 9, 2014—Ma kahi haʻawina mua loa, hōʻike ka poʻe noiʻi ua kūkulu lākou i kahi hoʻāʻo koko e hiki ke wānana me ka pololei kamahaʻo inā loaʻa nā kānaka olakino i ka maʻi Alzheimer.
Nowemapa 23, 2016 - Ua hoʻolaha ʻo US drugmaker Eli Lilly e hoʻopau ia i ka Phase 3 clinical trial o kāna Alzheimer's drug solanezumab. "ʻAʻole i lohi nui ka nui o ka emi ʻana o ka cognitive i nā poʻe maʻi i mālama ʻia me solanezumab i hoʻohālikelike ʻia me nā maʻi i mālama ʻia me ka placebo," i ʻōlelo ai ka hui ma kahi ʻōlelo.
Fepeluali 2017 - Hoʻomaha ka hui lāʻau lapaʻau ʻo Merck i nā hoʻokolohua hope loa o kāna verubecestat lāʻau Alzheimer ma hope o kahi noiʻi kūʻokoʻa i ʻike i ka lāʻau "ʻoi aku ka maikaʻi."
Pepeluali 28, 2019 - Ua hoʻopuka ka puke pai Nature Genetics i kahi noiʻi e hōʻike ana i ʻehā mau ʻano genetic hou e hoʻonui ai i ka maʻi o Alzheimer. ʻIke ʻia e hana pū kēia mau genes e hoʻomalu i nā hana kino e hoʻoikaika i ka ulu ʻana o ka maʻi.
ʻApelila 4, 2022 - Ua ʻike ʻia kahi noiʻi i paʻi ʻia i kēia ʻatikala he 42 mau genes e pili ana i ka ulu ʻana o ka maʻi o Alzheimer.
ʻApelila 7, 2022 - Ua hoʻolaha nā Centers for Medicare a me Medicaid Services e kaupalena ʻia ka uhi ʻana o ka lāʻau lapaʻau ʻo Alzheimer hoʻopaʻapaʻa a me ke kumukūʻai ʻo Aduhelm i nā poʻe e komo ana i nā hoʻokolohua lapaʻau kūpono.
Mei 4, 2022 - Ua hoʻolaha ka FDA i ka ʻae ʻana i kahi hōʻike diagnostic hou o Alzheimer. ʻO ia ka hōʻike diagnostic in vitro mua e hiki ke hoʻololi i nā mea hana e like me ka PET scans i hoʻohana ʻia i kēia manawa e ʻike i ka maʻi o Alzheimer.
Iune 30, 2022 - Ua ʻike ka poʻe ʻepekema i kahi moʻo e ʻike ʻia e hoʻonui i ka pilikia o ka wahine e hoʻomohala i ka maʻi Alzheimer, e hāʻawi ana i nā hōʻailona hou e pili ana i ke kumu e ʻoi aku ka nui o nā wahine ma mua o nā kāne e ʻike ʻia me ka maʻi. ʻO ka gene, O6-methylguanine-DNA-methyltransferase (MGMT), he kuleana koʻikoʻi i ka hiki i ke kino ke hoʻoponopono i ka pōʻino DNA i nā kāne a me nā wahine. Akā ʻaʻole i loaʻa i nā mea noiʻi kahi pilina ma waena o MGMT a me ka maʻi o Alzheimer i nā kāne.
Ianuali 22, 2024—Ua hōʻike ʻia kahi noiʻi hou ma ka puke pai ʻo JAMA Neurology e hiki ke nānā ʻia ka maʻi o Alzheimer me ka "pololei kiʻekiʻe" ma ka ʻike ʻana i kahi protein i kapa ʻia he phosphorylated tau, a i ʻole p-tau, i loko o ke koko kanaka. ʻO ka maʻi leo, hiki ke hana ma mua o ka hoʻomaka ʻana o nā hōʻailona.
Ka manawa hoʻouna: Jul-09-2024
